Journals / Gülhane Tıp Dergisi / 2012 / Cilt: 54 - Sayı: 3

Entegre [18f]-fluoro-2-deoksi-D-glikoz (FDG) pozitron emisyon tomografi/ bilgisayarlı tomografi görüntülemesinin küçük hücreli dışı akciğer kanseri evreleme ve radyoterapi tedavi hacim tanımlamasına etkisinin değerlendirilmesi

Evaluation of the impact of integrated [18f]-fluoro- 2-deoxy-D-glucose positron emission tomography/ computed tomography imaging on staging and radiotherapy treatment volume definition of nonsmall cell lung cancer

Pages
220–227
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Integrated PET/CT imaging allows selection of patients eligible for radical radiotherapy along with tailoring of radiotherapy target volumes to prevent overtreatment and undertreatment.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to evaluate the impact of integrated positron emission tomography (PET)/computed tomography (CT) imaging on staging and radiotherapy treatment volume definition of non-small cell lung cancer (NSCLC).
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Key Findings & Data:Thirty-nine patients with NSCLC referred to the Department of Radiation Oncology of Gulhane Military Medical Academy, for radical radiotherapy between June 2011 and December 2011 were enrolled in this study.
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Conclusion & Impact:Integrated PET/CT imaging allows selection of patients eligible for radical radiotherapy along with tailoring of radiotherapy target volumes to prevent overtreatment and undertreatment.
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Radyoterapi · Pozitron-emisyon tomografi ve bilgisayarlı tomografi · Florodeoksiglikoz F18

Abstract

The aim of this study was to evaluate the impact of integrated positron emission tomography (PET)/computed tomography (CT) imaging on staging and radiotherapy treatment volume definition of non-small cell lung cancer (NSCLC). Thirty-nine patients with NSCLC referred to the Department of Radiation Oncology of Gulhane Military Medical Academy, for radical radiotherapy between June 2011 and December 2011 were enrolled in this study. All patients underwent integrated PET/CT imaging in treatment position for initial assessment. For patients deemed suitable for radical radiotherapy, CTbased and integrated PET/CT imaging based radiotherapy treatment plans were generated to comparatively evaluate dose-volume parameters of both plans. Of the 39 patients initially assessed with integrated PET/CT imaging, 29 patients (74.4%) were deemed suitable for radical radiotherapy with curative intent. Fifteen patients (38.5%) were upstaged after integrated PET/CT staging. Of the 29 patients treated with radical radiotherapy at our department using integrated PET/CT imaging based radiation treatment planning (RTP), gross tumor volume was decreased in 16 patients (55.2%) and increased in 13 patients (44.8%) by incorporating PET/CT into RTP. Integrated PET/CT imaging allows selection of patients eligible for radical radiotherapy along with tailoring of radiotherapy target volumes to prevent overtreatment and undertreatment.

Özet

Bu çalışmanın amacı entegre pozitron emisyon tomografi (PET)/bilgisayarlı tomografi (BT) görüntülemesinin küçük hücreli dışı akciğer kanseri (KHDAK) evrelemesi ve tedavi hacmi tanımlamasına etkisinin değerlendirilmesidir. Haziran 2011 ile Aralık 2011 arasında KHDAK tanısıyla Gülhane Askeri Tıp Akademisi (GATA) Radyasyon Onkolojisi Anabilim Dalı’na yönlendirilen 39 hasta çalışmaya dahil edilmiştir. Başlangıç değerlendirmesi için tüm hastalara tedavi pozisyonunda entegre PET/BT görüntülemesi yapılmıştır. Radikal radyoterapi için uygun olduğu değerlendirilen hastalara BT tabanlı ve entegre PET/BT görüntülemesi tabanlı iki ayrı planlama, doz-hacim parametrelerinin bu iki planlamada karşılaştırılması için yapılmıştır. Entegre PET/BT görüntülemesiyle başlangıç değerlendirmesi yapılan 39 hastadan 29’u (%74.4) küratif amaçlı radikal radyoterapi için uygun olarak değerlendirilmiştir. Entegre PET/ BT görüntülemesi sonrası 15 hastada (%38.5) evre atlaması görülmüştür. PET/BT’nin radyoterapi planlamasına dahil edilmesiyle kliniğimizde entegre PET/BT görüntülemesi tabanlı radyoterapi planlaması kullanılarak tedavi edilen 29 hastadan 16’sında (%55.2) gros tümör hacmi azalmış, 13 hastada (%44.8) ise artmıştır. Entegre PET/BT görüntülemesi, fazla ve eksik tedavinin engellenmesi için radikal radyoterapiye uygun hastaların seçimiyle birlikte radyoterapi hedef hacimlerinin şekillendirilmesine imkan sağlar.

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Cite This Article

SAĞER, Ö., DİNÇOĞLAN, F., GAMSIZ, H., DEMİRAL, S., UYSAL, B., SÜRENKÖK, S., OYSUL, K., ARSLAN, N., BEYZADEOĞLU, M. M. (2012). Entegre [18f]-fluoro-2-deoksi-D-glikoz (FDG) pozitron emisyon tomografi/ bilgisayarlı tomografi görüntülemesinin küçük hücreli dışı akciğer kanseri evreleme ve radyoterapi tedavi hacim tanımlamasına etkisinin değerlendirilmesi. Gülhane Tıp Dergisi, Cilt: 54 - Sayı: 3, 220–227. https://ajindex.com/articles/225334

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