A New Sesquiterpene from Schisandra sphenanthera

Objective & Hypothesis:A new sesquiterpene, schisandrathera E (1) and seven dibenzocyclooctadiene lignans as schisantherin D (2), schisantherin B (3), tigloylgomisin P (4), schisphenin E (5), angeloylgomisin H (6), (+)-deoxyschizandrin (7), and (+)-gomisin K3 (8) were isolated from the leaves of Schisandra sphenanthera Rehder & E.H.Wilson.

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Key Findings & Data:Their structures were elucidated by spectroscopic and mass spectrometric analyses, including 1D-, 2D-NMR, HR-ESI-MS and ECD spectra.

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Conclusion & Impact:Compound 1 displayed moderate cytotoxicity against both PC3 and MCF4 cell lines in MTT assay with IC50 values of 22.60 and 7.80 µM, respectively.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Özet

A new sesquiterpene, schisandrathera E (1) and seven dibenzocyclooctadiene lignans as schisantherin D (2), schisantherin B (3), tigloylgomisin P (4), schisphenin E (5), angeloylgomisin H (6), (+)-deoxyschizandrin (7), and (+)-gomisin K3 (8) were isolated from the leaves of Schisandra sphenanthera Rehder & E.H.Wilson. Their structures were elucidated by spectroscopic and mass spectrometric analyses, including 1D-, 2D-NMR, HR-ESI-MS and ECD spectra. Compound 1 displayed moderate cytotoxicity against both PC3 and MCF4 cell lines in MTT assay with IC50 values of 22.60 and 7.80 µM, respectively.

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Cite This Article

MAI, N. T., LAN, H. T. T., ANH, B. T. M., DOAN, V. V., TAI, B. H., NHIEM, N. X., KIEM, P. V. (2020). A New Sesquiterpene from Schisandra sphenanthera. Records of Natural Products, Cilt: 14 - Sayı: 3, 171–176. https://ajindex.com/articles/308227

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