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Journals / Perinatoloji Dergisi / 2005 / Cilt: 13 - Sayı: 3

Frequency of genetic thrombophilia in severe intrauterine growth restriction

Şiddetli intrauterin gelişme yetersizliği olgularında genetik trombfili sıklığı

RAGIP ATAKAN AL
ETHEM SERDAR YALVAÇ
Esmen ÖZTÜRKOĞLU
Erol AKKÖK
Ömer KANDEMİR
İsmail DÖLEN
Pages
138–141
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: It seems that the frequency of genetic thrombophilia was increased in severe intrauterine growth restriction.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To investigate the frequency of genetic thrombophilia in pregnancy complicated with severe intrauterin growth restriction in which absent or reversed end-diastolic blood flow were detected.
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Key Findings & Data:Methods: We presented 17 cases with diagnosed as severe intrauterine growth restriction with absent or reversed end-diastolic blood flow and the test result of genetic thrombophilia (activated protein C resistance, protein C, free protein S antigen) were available.
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Conclusion & Impact:Conclusion: It seems that the frequency of genetic thrombophilia was increased in severe intrauterine growth restriction.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Fetal gelişim geriliği · Geriyedönük çalışma · Umbilikal arterler

Abstract

Objective: To investigate the frequency of genetic thrombophilia in pregnancy complicated with severe intrauterin growth restriction in which absent or reversed end-diastolic blood flow were detected. Methods: We presented 17 cases with diagnosed as severe intrauterine growth restriction with absent or reversed end-diastolic blood flow and the test result of genetic thrombophilia (activated protein C resistance, protein C, free protein S antigen) were available. Results: Genetic thrombophilia was detected in 11 (%64.7) cases. In three cases (%17.6), two factor were established. These ratios were higher than the incidence for the normal population. Conclusion: It seems that the frequency of genetic thrombophilia was increased in severe intrauterine growth restriction.

Özet

Amaç: Umbilikal arterde diyastol sonu akım kaybı veya ters akım saptanan şiddetli intrauterin gelişme yetersizliği (IUGY) olgularında trombofili sıklığını saptamak. Yöntem: 2003-2005 tarihleri arasında umbilikal arterde diyastol sonu akım kaybı veya ters akım saptanan ve genetik trombofili testleri yapılmış (aktive protein C rezistansı, protein C aktivitesi, serbest protein S antijenitesi) şiddetli intrauterin gelişme yetersizliği saptanan 17 olgunun sonuçları incelendi. Bulgular: Onbir vakada (%64.7) trombofili saptandı. Üç olguda (%17.6) iki faktör pozitifliği mevcuttu. Bu oranlar normal toplum için bildirilen değerlerden yüksektir. Sonuç: Şiddetli intrauterin gelişme yetersizliği saptanan olgularda daha yüksek oranda genetik trombofiliye rastlanabilir.

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Cite This Article

AL, R. A., YALVAÇ, E. S., ÖZTÜRKOĞLU, E., AKKÖK, E., KANDEMİR, Ö., DÖLEN, İ. (2005). Frequency of genetic thrombophilia in severe intrauterine growth restriction. Perinatoloji Dergisi, Cilt: 13 - Sayı: 3, 138–141. https://ajindex.com/articles/300365

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