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Journals / MN Kardiyoloji / 2005 / Cilt: 12 - Sayı: 5

The relationship between angiotensin converting enzyme gene polymorphism and carotis intima-media thickness in patients with essantial hypertension and healthy volunters

Esansiyel hipertansiyonlu hastalarda ve sağlıklı gönüllülerde karotis intima media kalınlığı ile anjiyotensin dönüştürücü enzim gen polimorfizmi arasındaki ilişki

Nezihi BARIŞ
Filiz ÖZERKAN
Bahri AKDENİZ
ULUS SALİH AKARCA
M. Remzi ÖNDER
Pages
309–313
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

ACE gene I/D polymorphism should be assessed at the follow-up of patients with HT

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The aim of present study was to investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and carotis intima-media thickness (IMT) in patients with essential hypertension and healthy volunteers.
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Key Findings & Data:Material and Methods: Fifty one patients with essential hypertension (HT) and 37 healthy volunteers were enrolled in this study.
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Conclusion & Impact:ACE gene I/D polymorphism should be assessed at the follow-up of patients with HT
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Karotis arterleri · Hipertansiyon · Peptidil-dipeptidaz A

Abstract

Aim: The aim of present study was to investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and carotis intima-media thickness (IMT) in patients with essential hypertension and healthy volunteers. Material and Methods: Fifty one patients with essential hypertension (HT) and 37 healthy volunteers were enrolled in this study. Physical examination, electrocardiography, routine biochemical tests, trans-thoracal echocardiography, measurement of carotis IMT and insertion (I)/deletion (D) genotyping for ACE gene were performed for all study population. All genotypic subgroups were compared according to IMT. Results: There was no difference among genotypic subgroups (DD, ID, II) for demographic parameters and risk factors in patients with HT and health volunteers. In hypertensive group IMT (10-1 mm) was measured 7.88±1.41; 7.99±1.48 and 6.54±0.86 in DD, ID and II genotype respectively (p=0.024). In healthy group, IMT was measured 6.40±0.82; 5.84±0.87 and 5.85±0.90 in DD, ID and II genotype respectively (p=0.164). Mean IMT was 7.75±1.45 in hipertansive group and 6.19±0.86 in healthy group (p<0.0001). Conclusion: IMT was found hihger in hypertensive group than healthy group, as expected. IMT was higher in patients with D allel (DD and ID) than II in hypertensive group. ACE gene I/D polymorphism should be assessed at the follow-up of patients with HT

Özet

Amaç: Çalışmanın amacı esansiyel hipertansiyonu olan hastalarda ve sağlıklı gönüllülerde karotis intima-media kalınlığı ile anjiyotensin dönüştürücü enzim (ACE) polimorfizmi arasında ilişki olup olmadığının araştırılmasıdır. Gereç ve Yöntem: Çalışmaya polikliniğimize müracaat eden 51 esansiyel hipertansiyon (HT) hastası ve 37 sağlıklı gönüllü alındı. Tüm çalışma grubuna fizik muayene, elektrokardiyografi, rutin biyokimyasal testler, transtorasik ekokardiyografi, karotis intima-media kalınlığı (İMK) ölçümü ve ACE geni için insersiyon (I)/delesyon (D) genotiplemesi yapıldı. Genotipik alt gruplar İMK açısından karşılaştırıldı. Bulgular: Çalışmaya alınan HT olan hastalarda ve sağlıklı gönüllülerde genotipik alt gruplar arasında (DD, ID, II) demografik veriler ve risk faktörleri açısından anlamlı fark saptanmadı. Hipertansif grupta İMK (10-1 mm) değerleri DD, ID ve II genotiplerinde sırası ile 7.88±1.41; 7.99±1.48 ve 6.54±0.86 bulundu (p=0.024). Sağlıklı gönüllülerde ise İMK değerleri DD grubunda 6.40±0.82; ID grubunda 5,84 ± 0,87 ve II grubunda 5.85±0.90 olarak ölçüldü (p=0.164). HT olan hastalarda ortalama İMK 7.75±1.45 iken sağlıklı gönüllülerde 6.19±0.86 olarak bulundu (p<0.0001). Sonuç: HT olanlarda sağlıklı gönüllülere göre İMK beklendiği üzere fazla bulunmuştur. HT olan grupta D alleli taşıyanlarda (DD ve ID) İMK II olanlara göre daha yüksektir. HT hastalarının takibinde ACE gen I/D polimorfizmi değerlendirilmesi gereken bir parametre olabilir.

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Cite This Article

BARIŞ, N., ÖZERKAN, F., AKDENİZ, B., AKARCA, U. S., ÖNDER, M. R. (2005). The relationship between angiotensin converting enzyme gene polymorphism and carotis intima-media thickness in patients with essantial hypertension and healthy volunters. MN Kardiyoloji, Cilt: 12 - Sayı: 5, 309–313. https://ajindex.com/articles/297981

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