Journals / Türk Kardiyoloji Derneği Arşivi / 2003 / Cilt: 31 - Sayı: 4

The relationship between severity of coronary artery disease and endothelial dysfunction

Koroner arter hastalığının ciddiyeti ile endotel disfonksiyonu arasındaki ilişki

Pages
198–203
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

FMD was significantly lower in Group I and II than Group III (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, the relationship was evaluated between Flow-Mediated Dilation (FMD) and Nitrate-Induced Dilation (NID) of brachial artery and severity of coronary artery disease.
📊
Key Findings & Data:Study group was consisted of 64 patients with angina pectoris who had established coronary artery disease documented by coronary angiography (Group I), 12 patients who had normal coronary arteries with abnormal exercise test (Group II) and 18 healthy subjects who had normal exercise test.
💡
Conclusion & Impact:FMD was significantly lower in Group I and II than Group III (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, the relationship was evaluated between Flow-Mediated Dilation (FMD) and Nitrate-Induced Dilation (NID) of brachial artery and severity of coronary artery disease. Study group was consisted of 64 patients with angina pectoris who had established coronary artery disease documented by coronary angiography (Group I), 12 patients who had normal coronary arteries with abnormal exercise test (Group II) and 18 healthy subjects who had normal exercise test. FMD and NID were calculated as the percent change in diameter compared to baseline of brachial artery. According the angiographic findings, Group I patients were divided into two subgroups as single or multi vessel disease. Results were compared among the groups. FMD was significantly lower in Group I and II than Group III (p

Özet

Çalışmada, brakiyal arterde akıma bağlı dilatasyon (Flow-Mediated dilation-FMD) ve nitratla indüklenmiş dilatasyon (Nitrate-Induced Dilation=NID) ile koroner arter hastalığının anjiyografik ciddiyeti arasındaki ilişki değerlendirildi. Çalışmaya kararlı anjina pektoris nedeniyle koroner anjiyografisi yapılan ve koroner arter hastalığı tanısı konan 64 hasta (Grup l), efor testi pozitif olup koroner anjiyografisi normal bulunan 12 olgu (Grup II) ile kontrol grubu olarak efor testi normal olan 18 sağlıklı olgu (Grup III) alındı. FMD ve NID, bazal brakiyal arter çapına göre olan artışların yüzdesi olarak değerlendirildi. Grup I hastaları koroner anjiyografi sonuçlarına göre tek veya çok damar hastaları olarak iki alt gruba ayrıldı. Sonuçlar gruplar arasında karşılaştırıldı. FMD değerleri hem Grup I hem de Grup II de, Grup III e göre anlamlı derecede daha düşük idi (p

🔖

Cite This Article

ERCAN, E., TENGİZ, İ., NALBANTGİL, İ., BARIŞ, N., GÜNERİ, S. (2022). The relationship between severity of coronary artery disease and endothelial dysfunction. Türk Kardiyoloji Derneği Arşivi, Cilt: 31 - Sayı: 4, 198–203. https://ajindex.com/articles/633849

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Gimbrone MA Jn Vascular endothetium in health and disease. Chapter 4. In Molecular cardiovascular medicine. Haber E, ed. New York: Scientific American Medicine 1995;49-6I 2. Simicmescu N, Simİonescu M: Endolhelml cell dysfunctions. New York, Plenum Press 1992. p 17 3. Celemajer DS, Soransen KE, Gooch VM, et al: Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:l 111-5 4. E. Ercan, C. Ceyhan, C. Gurgun, et al: The effects of cholesterol lowering therapy with Atorvastatin on flow-mediated vasodilalalion in patients with hypercholesterolemic coronary artery disease. Polish Heart J 200I;55:503-6 5. Jiang L,Shui-Ping Z, Xiang Ping L, et al: Non invasive detection of endotlielial dysfunction in patients with essential hypertension. Int J Cardiol 1997;61:165-9 6. John PL, Christos MP, Costas NV, et al: Peripheral vascular endothelial dysfunction in patients with angina pecioris and normal coronary arteriograms. J Am Coll Cardiol 1997;31: 541-6 7. Takeshi M, Hİrouki K, Kiyotaka K, et ul: Flow mediated cndothelium dependent dilatation of the brachinl arteries is impaired in patients with coronary spastic angina. Am Heart J 1997:133:263-7 8. Ravikumar R, Deepa R, Shanthiranî C, et al: Comparison of carotid intima-medin thickness, arterial stiffness, and brachial artery flow mediated dilatation in diabetic and nondiabelic subjects (The Chennai Urban Population Study [CUP5-91). Am J Cardiol 2002;90:702-7 9. Dalli E, Scgarra L, Ruvira J, et al: Brachial artery flow-medialed dilution in healthy men, men with risk factors, and men with acute myocardial infarction. Importance of occlusion-cuff position. Rev Esp Cardiol 2002;55;928-35 10. Lee IK, Kim HS, Bııe JH: Endotlielial dysfunction: its relationship with acuie hyperglycaemia and hyperlipidemia. Int J Clin Pract Suppl 2002; 129:59-64 11. Furumoto T, Saito N, Dong J, et al: Association of cardiovascular risk factors and endotlielial dysfunction in Japanese hypertensive patients: implications For early atherosclerosis. Hyperlens Res 2002;25:475-8D 12. Teragawa H, Kato M, Kurokawa J, et al: Endothelial dysfunction is an independent factor responsible for vasospastic angina. Clin Sci 2001;101:707-13 13. Corretti MC, Anderson TJ, Benjamin EJ, et al: Guidelines for the ultrasound assessment ofendolhelial-dependent flow-mediated vasodilation of the brachial artery. J Am Coll Cardiol 2002:39:257-65 14. Uchata A, Liebcrman EH, Gerhard MD, et al: Noninvasive