The suggested method was also applied to the determination of SAL in the drug formulations.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:This paper examined for the first time the possibilities of the usage of the cathodically pretreated boron-doped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry.
📊
Key Findings & Data:The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution.
💡
Conclusion & Impact:The suggested method was also applied to the determination of SAL in the drug formulations.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
This paper examined for the first time the possibilities of the usage of the cathodically pretreated boron-doped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution. Under the optimized experimental condition, using square-wave adsorptive stripping mode, the compound yielded a well-defined voltammetric response in BR buffer, pH 9.0 at +0.95 V (vs. Ag/AgCl) (after 30 s accumulation at an open circuit condition). A linear calibration graph was obtained in the concentration range of 4.15 to 83 μg mL-1(1.73x10-5-3.47x10-4M). A detection limit of 1.21 μg mL-1(5.06x10-6M) was observed. The suggested method was also applied to the determination of SAL in the drug formulations.
🔖
Cite This Article
PINAR, P. T., YARDIM, Y., ALİ, H. S., ABDULLAH, A. A., ŞENTÜRK, Z. (2018). Electroanalytical determination of salbutamol in pharmaceutical formulations using cathodicallypretreated boron-doped diamond electrode. Marmara Pharmaceutical Journal, Cilt: 22 - Sayı: 3, 460–468. https://ajindex.com/articles/283716
Kraft A, Doped diamond: A compact review on a new, versatile electrodematerial. Int J Electrochem Sci. 2007
Luong JHT, Male KB, Glennon JD. Boron-doped diamond electrode: synthesis, characterization, functionalization and analytical applications. Analyst. 2009
134(10):1965-1979. [3]Yiğit A, Yardım Y, Selçuk ZorerÖ, Şentürk Z. Electrochemical determination of pterostilbene at a cathodically pretreated boron-doped diamond electrode using square-wave adsorptive anodic stripping voltammetry in cationic surfactant media. Sens Actuator B-Chem. 2016
Yiğit A, Yardım Y, Şentürk Z. Voltammetric sensor based on boron-doped diamond electrode for simultaneous determination of paracetamol, caffeine, and aspirin in pharmaceutical formulations. IEEE Sens J. 2016
16(6): 1674-1680. [5]Saadi Ali H, Abdullah AA, Pınar PT, Yardım Y, Şentürk Z. Simultaneous voltammetric determination of vanillin and caffeine in food products using an anodically pretreated boron-doped diamond electrode: Its comparison with HPLC-DAD. Talanta. 2017
Samiec P, Švorc Ľ, Stanković DM, Vojs M, Marton M, Navrátilová Z. Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes. SensActuator B-Chem. 2017
Stanković DM, Švorc Ľ, Mariano JFML, Ortner A, Kalcher K. Electrochemical determination of natural drug colchicine in pharmaceuticals and human serum sample and its interaction with DNA. Electroanalysis. 2017
29(10): 2276-2281. [8]Talay Pınar P, Şentürk Z. Voltammetric investigation of antiviral drug valacyclovir at a boron-doped diamond electrode in different electrolyte media: Its determination enhanced by anionic surfactant in pharmaceuticals and biological fluids. Curr Pharm Anal. 2017
13(2): 175-187. [9]Caiyun L, Long W. Research on determination of clenbuterol and salbutamol in pork by SPE-HPLC. IEEE Sens J. 2011
Bernal JL, del Nozal MJ, Velasco H, Toribio L. HPLC versus SFC for the determination of salbutamol sulphate and its impurities in pharmaceuticals. J Liq Chromatogr Relat Technol. 1996
19(10): 1579-1589. [11]Geeta N, Baggi TR. An improved spectrophotometric method for the determination of salbutamol sulfate with 3-methylbenzthiazolinone-2-hydrazone. Microchem J. 1989
39(2): 137-144. [12]Rotta ET, Amantéa SL, Froehlich PE, Becker A. Determination