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Dergiler / Marmara Pharmaceutical Journal / 2018 / Cilt: 22 - Sayı: 3

Electroanalytical determination of salbutamol in pharmaceutical formulations using cathodicallypretreated boron-doped diamond electrode

Pınar TALAY PINAR
Yavuz YARDIM
Hoshyar Saadi ALİ
Abdullah Abdulwahed ABDULLAH
Zühre ŞENTÜRK
Sayfa
460–468
DOI
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The suggested method was also applied to the determination of SAL in the drug formulations.

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Amaç & Hipotez:This paper examined for the first time the possibilities of the usage of the cathodically pretreated boron-doped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry.
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Temel Bulgular & Veri:The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution.
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Sonuç & Katkı:The suggested method was also applied to the determination of SAL in the drug formulations.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

This paper examined for the first time the possibilities of the usage of the cathodically pretreated boron-doped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution. Under the optimized experimental condition, using square-wave adsorptive stripping mode, the compound yielded a well-defined voltammetric response in BR buffer, pH 9.0 at +0.95 V (vs. Ag/AgCl) (after 30 s accumulation at an open circuit condition). A linear calibration graph was obtained in the concentration range of 4.15 to 83 μg mL-1(1.73x10-5-3.47x10-4M). A detection limit of 1.21 μg mL-1(5.06x10-6M) was observed. The suggested method was also applied to the determination of SAL in the drug formulations.

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Bu Makaleye Atıf Yap

PINAR, P. T., YARDIM, Y., ALİ, H. S., ABDULLAH, A. A., ŞENTÜRK, Z. (2018). Electroanalytical determination of salbutamol in pharmaceutical formulations using cathodicallypretreated boron-doped diamond electrode. Marmara Pharmaceutical Journal, Cilt: 22 - Sayı: 3, 460–468. https://ajindex.com/articles/283716

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Kaynakça (12)

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