Novel Carbonic Anhydrase Activators in the Rats Exposed to H2O2

As a result of the obtained evidence, a decrease in carbonic anhydrase activity was observed in examined tissues exposed to H2O2, but A compound has activation effect on enzyme activity in liver, T compound has it in eryt- hrocyte and heart tissues, B compound has it in liver and erythrocytes.

📌 3 Key Takeaways

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Objective & Hypothesis:Carbonic anhydrase has an important role in attentional gating of memory storage, signal process and long term synaptic transformation beside its pH regulation, HCO- reabsorption and CO2 expiration tasks.

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Key Findings & Data:Within the study, in vivo effects of Benzofurane-2-yl 3-phenyl-3-methylcyclobutyl ketoxime A , Benzofurane-2-yl 3-methyl-3-mesitylcyclobutyl ketone thiosemicarbazone T , 1,3-bis 2-chlorbenzoyl imidazoline-2-thione B which are synthetic products and H2O2 H on the carbonic anhydrase activity in the liver, erythrocyte, heart and kidney tissues of male Wistar rat were analyzed.

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Conclusion & Impact:As a result of the obtained evidence, a decrease in carbonic anhydrase activity was observed in examined tissues exposed to H2O2, but A compound has activation effect on enzyme activity in liver, T compound has it in eryt- hrocyte and heart tissues, B compound has it in liver and erythrocytes.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Aktivasyon · Karbonik Anhidraz · H2O2

Abstract

Carbonic anhydrase has an important role in attentional gating of memory storage, signal process and long term synaptic transformation beside its pH regulation, HCO- reabsorption and CO2 expiration tasks. Within the study, in vivo effects of Benzofurane-2-yl 3-phenyl-3-methylcyclobutyl ketoxime A , Benzofurane-2-yl 3-methyl-3-mesitylcyclobutyl ketone thiosemicarbazone T , 1,3-bis 2-chlorbenzoyl imidazoline-2-thione B which are synthetic products and H2O2 H on the carbonic anhydrase activity in the liver, erythrocyte, heart and kidney tissues of male Wistar rat were analyzed. For this purpose, control group, separate groups for each of the synthetic products, H2O2 group and H2O2 combination group with synthetic products were created. As a result of the obtained evidence, a decrease in carbonic anhydrase activity was observed in examined tissues exposed to H2O2, but A compound has activation effect on enzyme activity in liver, T compound has it in eryt- hrocyte and heart tissues, B compound has it in liver and erythrocytes.

Özet

K arbonik anhidrazın pH düzenlenmesi, HCO- geri emilimi, CO’in solunumla atılması gibi görevlerinin yanısısıra, hafıza, sinyal prosesleri, uzun dönem sinaptik transformasyon olaylarında önemli rolleri vardır. Yapılan çalışmada, sentetik ürünler olan Benzofuran-2-il 3-fenil-3-metilsiklobutil ketoksim A , Benzofuran2-il 3-metil-3-mezitilsiklobutil keton tiyosemikarbazon T , 1,3-bis 2-klorobenzoil imidazolin-2-tiyon B ve HO’in karbonik anhidraz aktivitesi üzerine erkek Wistar karaciğer, eritrosit, kalp ve böbrek dokularında etkileri incelendi. Bu amaçla, kontrol grubu, her bir sentetik ürün için bir grup, H2O2 grubu ve sentetik ürünler ile HO kombinasyon grupları oluşturuldu. Elde edilen verilerden HO uygulan grupta bütün dokularda karbonik anhidraz aktivitesinde azalma olduğu görüldü. Bununla birlikte A maddesi karaciğerde aktivasyona neden olurken T maddesi eritrosit ve kalp dokularında, B maddesi ise karaciğer ve eritrositlerde aynı etkiyi gösterdi

Keywords

Aktivasyon Karbonik Anhidraz H2O2 In vivo tiyosemikarbazon activation Carbonic anhydrase in vivo thiosemicarbazone

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Cite This Article

KUZU, M., DEMİRDAĞ, R., ÖZKAYA, A., ÇOMAKLI, V., ŞAHİN, Z., DARDAĞAN, U., UZUN, K., KOCA, M. (2016). Novel Carbonic Anhydrase Activators in the Rats Exposed to H2O2. Hacettepe Journal of Biology and Chemistry, Cilt: 44 - Sayı: 4, 409–417. https://ajindex.com/articles/255939

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