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Journals / Turkish Journal of Pharmaceutical Sciences / 2017 / Cilt: 14 - Sayı: 1

Naringenin ve Kurşunun Sıçan Eritrosit Karbonik Anhidraz Enzimi Üzerine In Vivo Etkileri

In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme

MÜSLÜM KUZU
AHMET ÖZKAYA
ZAFER ŞAHİN
Üzeyir DAĞ
VEYSEL ÇOMAKLI
RAMAZAN DEMİRDAĞ
Pages
9–12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion:Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Carbonic anhydrase (CA) enzyme catalyses the reversible reactions of CO2 with water and takes part in metabolically important events such as systemic acid-base regulation and respiration.
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Key Findings & Data:In this study, in vivo effects of lead, which is a heavy metal and to which living beings are exposed by different ways, with naringenin, a flavanone, were investigated.
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Conclusion & Impact:Conclusion:Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Carbonic anhydrase (CA) enzyme catalyses the reversible reactions of CO2 with water and takes part in metabolically important events such as systemic acid-base regulation and respiration. In this study, in vivo effects of lead, which is a heavy metal and to which living beings are exposed by different ways, with naringenin, a flavanone, were investigated. Materials and Methods: For this purpose, four different rat groups were established and one of them was chosen as the control group. The other three groups were given lead, naringenin and lead+naringenin substances to analyze the changes in the CA enzyme of rat erythrocytes. Results:The research findings showed that the enzyme activity in the control group was higher than that in the other groups. The naringenin group showed the highest inhibition effect, while the lead group showed the lowest inhibition. Conclusion:Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme.

Özet

Amaç: Karbonik anhidraz (CA) enzimi CO2'nin su ile tersinir reaksiyonunu katalizler ve sistemik asit baz dengesi, solunum gibi metabolik açıdan oldukça önemli olaylarda görev alır. Bu çalışmada canlıların farklı yollarla maruz kaldığı bir ağır metal olan kurşun ile bir flavanon olan naringeninin enzim üzerine in vivo etkisi araştırıldı.Gereç ve Yöntemler: Bu amaçla, dört farklı sıçan grubu oluşturuldu ve bunlardan biri kontrol grubu olarak belirlendi. Diğer üç gruba ise kurşun, naringenin ve kurşun+naringenin maddeleri verildi ve eritrositlerdeki CA enzim aktivitesindeki değişimler incelendi. Bulgular: Araştırma bulguları kontrol grubundaki enzim aktivitesinin diğer gruplardan daha fazla olduğunu gösterdi. Kurşun grubu en düşük inhibisyon etkisini gösterirken, narigenin grubu en yüksek inhibisyon etkisini gösterdi.Sonuç: Bu nedenle naringeninin CA enzimi için kuvvetli bir inhibitör olduğu söylenebilir.

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Cite This Article

KUZU, M., ÖZKAYA, A., ŞAHİN, Z., DAĞ, Ü., ÇOMAKLI, V., DEMİRDAĞ, R. (2017). Naringenin ve Kurşunun Sıçan Eritrosit Karbonik Anhidraz Enzimi Üzerine In Vivo Etkileri. Turkish Journal of Pharmaceutical Sciences, Cilt: 14 - Sayı: 1, 9–12. https://ajindex.com/articles/403672

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