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Journals / Clinical and Experimental Health Sciences / 2020 / Cilt: 10 - Sayı: 3

Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reductase in Rats Exposed to Doxorubicin and Morin

Ahmet Gökhan AĞGÜL
Müslüm KUZU
Fatih Mehmet KANDEMİR
Sefa KÜÇÜKLER
Cüneyt ÇAĞLAYAN
Pages
228–234
Publication Date
2020-09-29
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The findings showed that doxorubicin and morin had similar properties in the tissues as to their effect on enzyme activities.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Carbonic anhydrase (CA), 6-phosphogluconate dehydrogenase (6PGD) and thioredoxin reductase (TrxR) enzymes are the essential biological molecules needed for metabolic processes in all living cells.
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Key Findings & Data:This study was designed to investigate the activities of CA, 6PGD and TrxR enzymes in the brain, kidney, liver, heart and testis tissues of the rats exposed to Dox and morin.
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Conclusion & Impact:Conclusion: The findings showed that doxorubicin and morin had similar properties in the tissues as to their effect on enzyme activities.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Doxorubicin · Morin · Carbonic Anhydrase

Abstract

Objective: Carbonic anhydrase (CA), 6-phosphogluconate dehydrogenase (6PGD) and thioredoxin reductase (TrxR) enzymes are the essential biological molecules needed for metabolic processes in all living cells. This study was designed to investigate the activities of CA, 6PGD and TrxR enzymes in the brain, kidney, liver, heart and testis tissues of the rats exposed to Dox and morin. Methods: Male Wistar albino rats were randomly divided into three groups as control, morin and DOX, each of them containing 7 rats. At the end of the experimental procedure, CA, 6PGD and TrxR enzyme activities in tissues of rats were determined spectrophotometrically. Results: In our study, we observed that DOX activated CA enzyme in liver and kidney tissues while inhibiting CA enzyme in the other tissues, activated 6PGD enzyme in the kidney, liver and heart tissues, and inhibited the TrxR enzyme in all the tissues. In addition, morin activated CA enzyme in the liver tissue while inhibiting CA enzyme in the brain, heart and testis tissues. Morin activated 6PGD enzyme activity while it inhibited TrxR enzyme in all the tissues. Conclusion: The findings showed that doxorubicin and morin had similar properties in the tissues as to their effect on enzyme activities.

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Cite This Article

AĞGÜL, A. G., KUZU, M., KANDEMİR, F. M., KÜÇÜKLER, S., ÇAĞLAYAN, C. (2020). Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reductase in Rats Exposed to Doxorubicin and Morin. Clinical and Experimental Health Sciences, Cilt: 10 - Sayı: 3, 228–234. https://ajindex.com/articles/481442

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