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Journals / Güncel Retina Dergisi / 2018 / Cilt: 2 - Sayı: 1

Etiopathogenesis in Retinopathy of Prematurity

Prematüre Retinopatisinde Etyopatogenez

Pehmen Yasin ÖZCAN
Pages
5–12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Based upon in animal models of oxygen induced retinopthy (OIR) exogenous factors like oxygen levels, oxidative stress, inflammation and cytokines, several signaling pathways and their receptors have been linked to pathogenesis of ROP, as well

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Retinopathy of prematurity (ROP) is a potentially blinding diasease associated with low gestational age and birth weight.
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Key Findings & Data:Subsequently, an increase in metabolic demands and inadequate vascularization lead to hypoxia that triggers pathologic neovascularization process, which may lead to detachment in retinal tissue.
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Conclusion & Impact:Based upon in animal models of oxygen induced retinopthy (OIR) exogenous factors like oxygen levels, oxidative stress, inflammation and cytokines, several signaling pathways and their receptors have been linked to pathogenesis of ROP, as well
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Retinopathy of prematurity (ROP) is a potentially blinding diasease associated with low gestational age and birth weight. Supression of growth factors due to hyperoxia and loss of maternal-fetal interaction cause impaired develpoment of retinal vascularization. Subsequently, an increase in metabolic demands and inadequate vascularization lead to hypoxia that triggers pathologic neovascularization process, which may lead to detachment in retinal tissue. Vascular endothelial growth factor (VEGF) has a key role both physiologic and pathologic vascularization. Based upon in animal models of oxygen induced retinopthy (OIR) exogenous factors like oxygen levels, oxidative stress, inflammation and cytokines, several signaling pathways and their receptors have been linked to pathogenesis of ROP, as well

Özet

Prematüre retinopatisi düşük doğum haftası ve doğum ağırlığı ile ilişkili, potansiyel olarak körlük ile sonuçlanabilen bir hastalıktır. Hiperoksinin neden olduğu büyüme faktörlerinin baskılanması ve maternal-fetal etkşileşimin erken dönemde kesintiye uğraması retinanın normal damar gelişim sürecinde aksamaya yol açar. Bu aksamayı takiben ortaya çıkan metabolik ihtiyaçlardaki artış ve yetersiz vaskülarizasyon, retina dekolmanına yol açabilen patolojik neovaskülarizasyon sürecini başlatan hipoksiye yol açar. Vasküler endotelyal büyüme faktörü (VEGF) hem fizyolojik hem de patolojik damar gelişiminde anahtar bir role sahiptir. Hayvan modelleri aracılığı ile oluşturulan 'oksijenin indüklediği retinopati (OIR)' tablosu ile yapılan deneysel araştırmalar doğrultusunda okisjen seviyeleri, oksidatif stres, inflamasyon gibi dış faktörlerin, sitokinler, sinyal yolakları ve bunlara ait reseptörlerin de prematüre retinopatisi patogenezi ile bağlantılı olduğu gözlenmiştir

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Cite This Article

ÖZCAN, P. Y. (2018). Etiopathogenesis in Retinopathy of Prematurity. Güncel Retina Dergisi, Cilt: 2 - Sayı: 1, 5–12. https://ajindex.com/articles/186424

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