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Journals / Doğu Karadeniz Sağlık Bilimleri Dergisi / 2026 / Cilt: 5 Sayı: 2

The Importance of Cribriform Pattern Percentage in Prostatic Adenocarcinoma Cases Diagnosis with Gleason Score 7: Our Clinical Experience

Gleason Skor 7 Tanılı Prostatik Adenokarsinom Olgularında Kribriform Patern Yüzdesinin Önemi: Klinik Tecrübemiz

Merve Meryem Kıran(ankara bilkent şehir hastanesi)0000-0003-2498-0472
Onur Enes Tunç(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ÜROLOJİ ANABİLİM DALI)0009-0006-4307-7843
Asım Özayar(ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ÜROLOJİ ANABİLİM DALI)0000-0002-5302-1927
Aylin Yazgan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ PATOLOJİ ANABİLİM DALI)0000-0002-0416-8324
Pages
148–156
Publication Date
2026-07-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, further large-scale and long-term studies are required.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Prostate cancer is the second most common cancer among men worldwide.
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Key Findings & Data:Since 2014, all tumors with cribriform patterns have been classified as Gleason Score 4, and reporting their presence has been recommended.
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Conclusion & Impact:However, further large-scale and long-term studies are required.
🔬Design:Araştırma Makalesi
📍Scope:2014 Verileri
⚙️Variables:prostat · kribriform patern · adenokarsinom

Abstract

Prostate cancer is the second most common cancer among men worldwide. The Gleason Score (GS) system is a crucial prognostic parameter in prostate cancer management. The cribriform pattern is a morphological subtype associated with aggressive disease behaviour in prostatic adenocarcinomas. Since 2014, all tumors with cribriform patterns have been classified as Gleason Score 4, and reporting their presence has been recommended. In this study, number of 101 Gleason Score 7 (Grade Groups 2 and 3) prostate adenocarcinoma cases who underwent robot-assisted radical prostatectomy between 2012 and 2019 at Ankara Atatürk Training and Research Hospital and Ankara Bilkent City Hospital were analyzed. Significant associations were found between the cribriform pattern percentage and multifocality, perineural invasion, positive surgical margins, and seminal vesicle infiltration. Additionally, an inverse relationship was observed between the cribriform pattern percentage and lymphovascular invasion. Although no significant relationship was found between postoperative PSA levels and cribriform morphology. The findings suggest that the cribriform pattern percentage should be considered a prognostic parameter in prostate cancer management. However, further large-scale and long-term studies are required.

Özet

Prostat kanseri, dünya genelinde erkeklerde en sık görülen ikinci kanser türüdür. Gleason Skor (GS) sistemi, prostat kanseri hastalarının yönetiminde temel bir prognostik parametredir. Kribriform patern prostatik adenokarsinomlarda agresif seyir ile ilişkilendirilen bir morfolojik paterndir. 2014 yılından beri tüm kribriform patern içeren tümörler Gleason Skor 4 olarak sınıflandırılmış ve bu morfolojinin raporlanması önerilmiştir. Bu çalışmada, 2012-2019 yılları arasında Ankara Atatürk Eğitim ve Araştırma Hastanesi ile Ankara Bilkent Şehir Hastanesi'nde robotik yardımlı radikal prostatektomi yapılan 101 adet Gleason Skor 7 (Grade Grup 2 ve 3) prostat adenokarsinom olgusu incelenmiştir. Kribriform patern yüzdesi ile multifokalite, perinöral invazyon, cerrahi sınır tutulumu ve seminal vezikül infiltrasyonu varlığı arasında anlamlı ilişkiler saptanmıştır. Ayrıca, kribriform patern yüzdesinin artışı ile lenfovasküler invazyon oranı arasında ters bir ilişki gözlenmiştir. Ayrıca postoperatif PSA seviyeleri ile kribriform morfoloji arasında anlamlı bir ilişki saptanmamıştır. Sonuçlar prostat kanseri yönetiminde kribriform patern yüzdesinin prognostik bir parametre olarak dikkate alınması gerektiği düşündürmektedir. Ancak geniş ölçekli ve uzun takip süreli çalışmalara ihtiyaç duyulmaktadır.

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Cite This Article

Kıran, M. M., Tunç, O. E., Özayar, A., Yazgan, A. (2026). The Importance of Cribriform Pattern Percentage in Prostatic Adenocarcinoma Cases Diagnosis with Gleason Score 7: Our Clinical Experience. Doğu Karadeniz Sağlık Bilimleri Dergisi, Cilt: 5 Sayı: 2, 148–156. https://doi.org/10.59312/ebshealth.1774432

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