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Journals / TOGÜ Sağlık Bilimleri Dergisi / 2026 / Cilt: 6 Sayı: 3

IMPACT OF SERUM ESTRADIOL, PROGESTERONE, AND LUTEINIZING HORMONE LEVELS ON IVF OUTCOMES IN GnRH ANTAGONIST CYCLES: A RETROSPECTIVE CROSS-SECTIONAL STUDY

GNRH ANTAGONİST SİKLUSLARINDA SERUM ESTRADİOL, PROGESTERON VE LUTEİNİZAN HORMON DÜZEYLERİNİN IVF SONUÇLARINA ETKİSİ: RETROSPEKTİF KESİTSEL BİR ÇALIŞMA

Aziz İhsan Tavuz(Momart Tüp Bebek Merkezi)0000-0002-7678-6981
Mustafa Hakan Acer(GAZİOSMANPAŞA ÜNİVERSİTESİ, GAZİOSMANPAŞA ÜNİVERSİTESİ ARAŞTIRMA VE UYGULAMA MERKEZİ)0000-0002-7007-545X
Gülşah İlhan(istanbul eğitim ve araştırma hastanesi)0000-0002-8236-4742
Pages
562–570
Publication Date
2026-09-30
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Interpretation of hormonal dynamics together with ovarian response parameters may support individualized IVF management strategies.

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Objective & Hypothesis:OBJECTIVE: To evaluate associations between serum estradiol (E2), progesterone (P4), and luteinizing hormone (LH) levels measured on the day of ovulation trigger and laboratory as well as early pregnancy outcomes in GnRH antagonist IVF/ICSI cycles.
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Key Findings & Data:METHODS: This retrospective cross-sectional study included 473 antagonist IVF/ICSI cycles performed in 2021.
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Conclusion & Impact:Interpretation of hormonal dynamics together with ovarian response parameters may support individualized IVF management strategies.
🔬Design:Araştırma Makalesi
📍Scope:2021 Verileri
⚙️Variables:Estradiol · Gonadotropin Salıverici Hormon Antagonistleri · İn Vitro Fertilizasyon

Abstract

OBJECTIVE: To evaluate associations between serum estradiol (E2), progesterone (P4), and luteinizing hormone (LH) levels measured on the day of ovulation trigger and laboratory as well as early pregnancy outcomes in GnRH antagonist IVF/ICSI cycles. METHODS: This retrospective cross-sectional study included 473 antagonist IVF/ICSI cycles performed in 2021. Trigger-day E2, P4, and LH levels were assessed in relation to total oocyte count, metaphase II (MII/M2) oocytes, immature oocyte subgroups (MI, GV), degenerated oocytes, embryo number, blastocyst developmental parameters, and β-hCG positivity using correlation analyses. Multivariable logistic regression was performed to identify independent predictors of β-hCG positivity. Premature luteinization was defined as P4 > 1.5 ng/mL on trigger day. RESULTS: Estradiol levels correlated positively with total oocyte count, MII oocytes, embryo number, and β-hCG positivity (all p<0.001). LH levels correlated negatively with oocyte yield and maturity (p<0.001). Progesterone showed mixed effects, including higher immature oocyte counts alongside favorable associations with selected blastocyst morphology parameters. In multivariable analysis, total oocyte count was the only independent predictor of β-hCG positivity. CONCLUSION: Trigger-day hormone profiling provides meaningful prognostic information in GnRH antagonist cycles. Interpretation of hormonal dynamics together with ovarian response parameters may support individualized IVF management strategies.

Özet

AMAÇ: GnRH antagonist IVF/ICSI sikluslarında ovulasyon tetikleme günü serum estradiol (E2), progesteron (P4) ve luteinizan hormon (LH) düzeylerinin; oosit sayısı ve olgunluğu, embriyo gelişimi, blastokist morfolojisi ve β-hCG pozitifliği ile ilişkisini değerlendirmektir. YÖNTEM: 2021 yılında uygulanan 473 GnRH antagonist IVF/ICSI siklusu retrospektif kesitsel olarak incelendi. Tetikleme günü E2, P4 ve LH düzeyleri ile toplam oosit sayısı, MII (M2) oosit sayısı, immatür oosit alt grupları (MI, GV), dejenere oosit sayısı, embriyo sayısı, blastokist parametreleri ve β-hCG pozitifliği arasındaki ilişkiler korelasyon analizleriyle değerlendirildi; β-hCG pozitifliği için çok değişkenli lojistik regresyon uygulandı. Prematür luteinizasyon P4 > 1,5 ng/mL olarak tanımlandı. BULGULAR: E2 düzeyi toplam oosit sayısı, MII (M2) oosit sayısı, embriyo sayısı ve β-hCG pozitifliği ile pozitif korelasyon gösterdi (tümü için p<0,001). LH düzeyi toplam oosit sayısı ve MII (M2) oosit sayısı ile negatif koreleydi (p<0,001). P4; immatür oosit sayılarında artışla ilişkiliyken bazı blastokist morfoloji parametrelerinde daha iyi değerlerle ilişkili bulundu. Çok değişkenli analizde β-hCG pozitifliğinin bağımsız belirleyicisi olarak yalnızca toplam oosit sayısı saptandı. SONUÇ: GnRH antagonist sikluslarda tetikleme günü hormon profili, özellikle ovarian yanıt ve embriyolojik çıktılar açısından prognostik bilgi sağlar. Klinik karar verme sürecinde hormon düzeylerinin tek başına eşik değerlerle değil, ovarian yanıt bağlamında birlikte yorumlanması bireyselleştirilmiş IVF yönetimini destekleyebilir.

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Cite This Article

Tavuz, A. İ., Acer, M. H., İlhan, G. (2026). IMPACT OF SERUM ESTRADIOL, PROGESTERONE, AND LUTEINIZING HORMONE LEVELS ON IVF OUTCOMES IN GnRH ANTAGONIST CYCLES: A RETROSPECTIVE CROSS-SECTIONAL STUDY. TOGÜ Sağlık Bilimleri Dergisi, Cilt: 6 Sayı: 3, 562–570. https://doi.org/10.52369/togusagbilderg.1888632

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