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Journals / Bozok Veterinary Sciences / 2025 / Cilt: 6 Sayı: 2

MicroRNAs: Their Importance and Roles in Ruminant Nutrition

MikroRNA'lar: Ruminant Beslenmesinde Önemi ve Rolleri

Murat Eren(ERCİYES ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ)0000-0002-8544-7340
Fatih Aydin(KIRIKKALE ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ)0009-0007-0448-2982
Pages
125–131
Publication Date
2025-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review aims to systematically evaluate the potential applicability of miRNAs in feeding strategies in light of the current literature.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:MicroRNAs (miRNAs) are 20–24 nucleotide long, single-stranded, non-coding RNA molecules that regulate gene expression at the post-transcriptional level, thereby exerting significant effects on cellular functions.
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Key Findings & Data:Furthermore, the influence of diet composition and feeding strategies on miRNA expression profiles suggests that these molecules may serve as potential biomarkers reflecting nutritional status and metabolic adaptations in ruminants.
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Conclusion & Impact:This review aims to systematically evaluate the potential applicability of miRNAs in feeding strategies in light of the current literature.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:MikroRNA · Ruminant beslenmesi · Gen ekspresyonu

Abstract

MicroRNAs (miRNAs) are 20–24 nucleotide long, single-stranded, non-coding RNA molecules that regulate gene expression at the post-transcriptional level, thereby exerting significant effects on cellular functions. Their roles in fundamental biological processes such as growth, development, energy balance, and metabolism highlight their importance in animal nutrition and productivity. In ruminants, miRNAs have been reported to play key regulatory roles in rumen development, modulation of the microbial ecosystem, immune response, and improvement of nutrient utilization efficiency. Furthermore, the influence of diet composition and feeding strategies on miRNA expression profiles suggests that these molecules may serve as potential biomarkers reflecting nutritional status and metabolic adaptations in ruminants. However, the specific molecular mechanisms underlying the functions of miRNAs in ruminant nutrition remain incompletely understood. Therefore, further research in this field is essential to enhance both productivity and animal health in a sustainable manner. This review aims to systematically evaluate the potential applicability of miRNAs in feeding strategies in light of the current literature.

Özet

MikroRNA’lar (miRNA’lar), 20–24 nükleotid uzunluğunda, tek sarmallı, kodlamayan RNA molekülleri olup gen ekspresyonunu post-transkripsiyonel düzeyde düzenleyerek hücresel işlevler üzerinde önemli etkiler göstermektedir. Büyüme, gelişim, enerji dengesi ve metabolizma gibi temel biyolojik süreçlerdeki rolleri, hayvan besleme ve verimliliği açısından dikkat çekmektedir. Ruminantlarda miRNA’ların; rumen gelişimi, mikrobiyal ekosistemin dengelenmesi, bağışıklık yanıtının modülasyonu ve besin kullanım etkinliğinin artırılmasında kritik düzenleyici mekanizmalar olduğu bildirilmektedir. Ayrıca, yem bileşimi ve besleme stratejilerinin miRNA ekspresyon profillerini etkilemesi, bu moleküllerin ruminantların besleme durumunu ve metabolik adaptasyonlarını yansıtan biyomarkerlar olarak kullanım potansiyelini ortaya koymaktadır. Bununla birlikte, miRNA’ların ruminant beslemedeki spesifik etki mekanizmaları hâlen tam olarak aydınlatılamamıştır. Dolayısıyla, bu alanda yapılacak ileri araştırmalar hem üretkenliğin hem de hayvan sağlığının sürdürülebilir biçimde geliştirilmesine katkı sağlayacaktır. Bu derleme, mevcut literatür ışığında, miRNA’ların ruminant beslenme stratejilerinde kullanılabilirliğinin potansiyellerini sistematik olarak değerlendirmeyi amaçlamaktadır.

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Cite This Article

Eren, M., Aydin, F. (2025). MicroRNAs: Their Importance and Roles in Ruminant Nutrition. Bozok Veterinary Sciences, Cilt: 6 Sayı: 2, 125–131. https://doi.org/10.58833/bozokvetsci.1804179

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