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Dergiler / Bozok Veterinary Sciences / 2025 / Cilt: 6 Sayı: 2

MikroRNA'lar: Ruminant Beslenmesinde Önemi ve Rolleri

MicroRNAs: Their Importance and Roles in Ruminant Nutrition

Murat Eren(ERCİYES ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ)0000-0002-8544-7340
Fatih Aydin(KIRIKKALE ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ)0009-0007-0448-2982
Sayfa
125–131
Yayın Tarihi
2025-12-31
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

MikroRNA’lar (miRNA’lar), 20–24 nükleotid uzunluğunda, tek sarmallı, kodlamayan RNA molekülleri olup gen ekspresyonunu post-transkripsiyonel düzeyde düzenleyerek hücresel işlevler üzerinde önemli etkiler göstermektedir.

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Amaç & Hipotez:MikroRNA’lar (miRNA’lar), 20–24 nükleotid uzunluğunda, tek sarmallı, kodlamayan RNA molekülleri olup gen ekspresyonunu post-transkripsiyonel düzeyde düzenleyerek hücresel işlevler üzerinde önemli etkiler göstermektedir.
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Temel Bulgular & Veri:Büyüme, gelişim, enerji dengesi ve metabolizma gibi temel biyolojik süreçlerdeki rolleri, hayvan besleme ve verimliliği açısından dikkat çekmektedir.
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Sonuç & Katkı:Bu derleme, mevcut literatür ışığında, miRNA’ların ruminant beslenme stratejilerinde kullanılabilirliğinin potansiyellerini sistematik olarak değerlendirmeyi amaçlamaktadır.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:MikroRNA · Ruminant beslenmesi · Gen ekspresyonu

Özet

MikroRNA’lar (miRNA’lar), 20–24 nükleotid uzunluğunda, tek sarmallı, kodlamayan RNA molekülleri olup gen ekspresyonunu post-transkripsiyonel düzeyde düzenleyerek hücresel işlevler üzerinde önemli etkiler göstermektedir. Büyüme, gelişim, enerji dengesi ve metabolizma gibi temel biyolojik süreçlerdeki rolleri, hayvan besleme ve verimliliği açısından dikkat çekmektedir. Ruminantlarda miRNA’ların; rumen gelişimi, mikrobiyal ekosistemin dengelenmesi, bağışıklık yanıtının modülasyonu ve besin kullanım etkinliğinin artırılmasında kritik düzenleyici mekanizmalar olduğu bildirilmektedir. Ayrıca, yem bileşimi ve besleme stratejilerinin miRNA ekspresyon profillerini etkilemesi, bu moleküllerin ruminantların besleme durumunu ve metabolik adaptasyonlarını yansıtan biyomarkerlar olarak kullanım potansiyelini ortaya koymaktadır. Bununla birlikte, miRNA’ların ruminant beslemedeki spesifik etki mekanizmaları hâlen tam olarak aydınlatılamamıştır. Dolayısıyla, bu alanda yapılacak ileri araştırmalar hem üretkenliğin hem de hayvan sağlığının sürdürülebilir biçimde geliştirilmesine katkı sağlayacaktır. Bu derleme, mevcut literatür ışığında, miRNA’ların ruminant beslenme stratejilerinde kullanılabilirliğinin potansiyellerini sistematik olarak değerlendirmeyi amaçlamaktadır.

Abstract

MicroRNAs (miRNAs) are 20–24 nucleotide long, single-stranded, non-coding RNA molecules that regulate gene expression at the post-transcriptional level, thereby exerting significant effects on cellular functions. Their roles in fundamental biological processes such as growth, development, energy balance, and metabolism highlight their importance in animal nutrition and productivity. In ruminants, miRNAs have been reported to play key regulatory roles in rumen development, modulation of the microbial ecosystem, immune response, and improvement of nutrient utilization efficiency. Furthermore, the influence of diet composition and feeding strategies on miRNA expression profiles suggests that these molecules may serve as potential biomarkers reflecting nutritional status and metabolic adaptations in ruminants. However, the specific molecular mechanisms underlying the functions of miRNAs in ruminant nutrition remain incompletely understood. Therefore, further research in this field is essential to enhance both productivity and animal health in a sustainable manner. This review aims to systematically evaluate the potential applicability of miRNAs in feeding strategies in light of the current literature.

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Bu Makaleye Atıf Yap

Eren, M., Aydin, F. (2025). MikroRNA'lar: Ruminant Beslenmesinde Önemi ve Rolleri. Bozok Veterinary Sciences, Cilt: 6 Sayı: 2, 125–131. https://doi.org/10.58833/bozokvetsci.1804179

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