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Journals / Türk Veteriner Cerrahi Dergisi / 2026 / Cilt: 4 Sayı: 1

Evaluation of Gastrin, Amylase, Homocysteine, and Cystatin C as Indicators of Renal Failure Severity in Dogs

Köpeklerde Böbrek Yetmezliği Şiddetinin Belirteçleri Olarak Gastrin, Amilaz, Homosistein ve Cystatin C’nin Değerlendirilmesi

Zeki Yılmaz(ULUDAĞ ÜNİVERSİTESİ)0000-0001-9836-0749
Didem Algan(BURSA ULUDAĞ ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ, VETERİNERLİK İÇ HASTALIKLARI ANABİLİM DALI)0009-0005-7717-9330
Tuğba Varlik(BURSA ULUDAĞ ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ, VETERİNERLİK İÇ HASTALIKLARI ANABİLİM DALI)0009-0009-1906-9810
Yağmur Tunbul(BURSA ULUDAĞ ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ, VETERİNERLİK İÇ HASTALIKLARI ANABİLİM DALI)0009-0007-3920-3170
Pages
8–12
Publication Date
2025-12-25
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The findings indicate that although serum gastrin, amylase, and Hcy tend to increase primarily in CRF, serum cystatin C is the only parameter that consistently differentiates between ARF and CRF.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The potential diagnostic value of gastrin, amylase, homocysteine (Hcy), and cystatin C (Cys-C) in differentiating acute (ARF) from chronic renal failure (CRF) remains largely unclear in veterinary medicine.
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Key Findings & Data:Material and Methods: A total of 45 dogs were divided equally into three groups: dogs with ARF, dogs with CRF, and healthy controls.
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Conclusion & Impact:The findings indicate that although serum gastrin, amylase, and Hcy tend to increase primarily in CRF, serum cystatin C is the only parameter that consistently differentiates between ARF and CRF.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Amilaz · gastrin · homosistein

Abstract

Objective: The potential diagnostic value of gastrin, amylase, homocysteine (Hcy), and cystatin C (Cys-C) in differentiating acute (ARF) from chronic renal failure (CRF) remains largely unclear in veterinary medicine. This study aimed to assess the diagnostic potential of these four biomarkers in dogs with renal failure. Material and Methods: A total of 45 dogs were divided equally into three groups: dogs with ARF, dogs with CRF, and healthy controls. Results: Serum blood urea nitrogen (BUN), creatinine, and Cys-C levels were found to have elevated in dogs with renal failure compared to controls (p<0.001). Mean serum gastrin, Hcy, and amylase concentrations did not differ significantly between ARF dogs and controls, but were markedly higher in dogs with CRF than in the other two groups (p<0.01–0.001). The findings indicate that although serum gastrin, amylase, and Hcy tend to increase primarily in CRF, serum cystatin C is the only parameter that consistently differentiates between ARF and CRF. Conclusion: This comprehensive analysis provides new insights into the diagnostic utility of less commonly used renal biomarkers in dogs and supports cystatin C as a valuable marker for distinguishing the chronicity of renal injury.

Özet

Gastrin, amilaz, homosistein (Hcy) ve cystatin C (Cys-C) gibi belirteçlerin akut (ARF) ve kronik böbrek yetmezliğini (CRF) ayırt etmedeki potansiyel tanısal değeri, veteriner hekimlikte büyük ölçüde belirsizliğini korumaktadır. Bu çalışma, renal yetmezlikli köpeklerde bu dört biyobelirtecin tanısal potansiyelinin değerlendirilmesini amaçlamıştır. Toplam 45 köpek ARF’li, CRF’li ve sağlıklı kontrollere olmak üzere üç gruba eşit şekilde ayrılmıştır. Serum kan üre nitrojeni (BUN), kreatinin ve Cys-C düzeylerinin, kontrol köpeklere kıyasla renal yetmezlikli köpeklerde arttığı saptanmıştır (P<0.001). Ortalama serum gastrin, Hcy ve amilaz konsantrasyonları ARF’li köpekler ile kontroller arasında anlamlı fark göstermemiş, ancak CRF’li köpeklerde her iki gruba göre belirgin şekilde daha yüksek bulunmuştur (P<0.01–0.001). Elde edilen bulgular, serum gastrin, amilaz ve Hcy’nin özellikle CRF’de artış eğiliminde olduğunu, ancak ARF ile CRF’yi tutarlı biçimde ayırt edebilen tek parametrenin serum cystatin C olduğunu göstermektedir. Bu kapsamlı değerlendirme, köpeklerde daha az kullanılan renal biyobelirteçlerin tanısal önemine ilişkin yeni bilgiler sunmakta ve cystatin C’nin böbrek hasarının kronikliğini ayırt etmede değerli bir belirteç olduğunu desteklemektedir.

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Cite This Article

Yılmaz, Z., Algan, D., Varlik, T., Tunbul, Y. (2025). Evaluation of Gastrin, Amylase, Homocysteine, and Cystatin C as Indicators of Renal Failure Severity in Dogs. Türk Veteriner Cerrahi Dergisi, Cilt: 4 Sayı: 1, 8–12. https://ajindex.com/articles/1603460

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