Journals / Astım Allerji İmmünoloji / 2013 / Cilt: 11 - Sayı: 3

Delayed severe systemic reaction (anaphylaxis) after subcutaneous immunotherapy injections: Case report

Subkütan immünoterapi enjeksiyonu sonrası geç dönemde gelişen şiddetli sistemik reaksiyon (anafilaksi): Olgu sunumu

Pages
204–207
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We want to emphasize that severe late onset systemic reactions are rare but could occur after subcutaneous immunotherapy injections.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Currently, allergen specific immunotherapy is administered to allergic rhinitis or asthmatic patients with uncontrolled symptoms despite medical treatment and avoidance of environmental allergens.
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Key Findings & Data:Although almost all severe systemic reactions are reported to begin within 30 minutes after administration of injections, late onset reactions could be seen.
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Conclusion & Impact:We want to emphasize that severe late onset systemic reactions are rare but could occur after subcutaneous immunotherapy injections.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Currently, allergen specific immunotherapy is administered to allergic rhinitis or asthmatic patients with uncontrolled symptoms despite medical treatment and avoidance of environmental allergens. Local or systemic reactions can occur after subcutaneous immunotherapy. Although almost all severe systemic reactions are reported to begin within 30 minutes after administration of injections, late onset reactions could be seen. Our case was 15 years old female patient with asthma whose complaints could not controlled by medical treatment and subcutaneous immunotherapy with “Dermatophagoides farinae” extract that she was sensitized was administered to her. Severe systemic reaction (anaphylaxis) has developed in the patient within fourth hours of post-injection observation period at the ma- intenance dose of 0.8 mL. We want to emphasize that severe late onset systemic reactions are rare but could occur after subcutaneous immunotherapy injections.

Özet

Günümüzde çevresel korunma ve ilaç tedavisine rağmen şikayetleri kontrol altına alınamayan allerjik rinit veya allerjik astım tanılı hastaların tedavisinde allerjen spesifik immünoterapi uygulanmaktadır. Uygulanan allerjen immünoterapisine bağlı lokal ve sistemik reaksiyonlar ortaya çıkabilmektedir. Şiddetli sistemik reaksiyonların neredeyse tamamı ilk 30 dakikada ortaya çıkmasına rağmen, geç tip sistemik reaksiyonlar nadir de olsa görülebilmektedir. Olgumuz, astım tanısı olan 15 yaşında kadın hastaydı ve verilen medikal tedaviye rağmen şikayetlerinin kontrol altına alınamaması nedeniyle, duyarlı olduğu “Dermatophagoides farinae” ekstresiyle subkütan immünoterapi başlanıldı. Subkütan enjeksiyonun (idame dozunda, 0.8 mL) dördüncü saatinde, hastada şiddetli sistemik reaksiyon (anafilaksi) gelişti. Bu olgu nedeniyle, immünoterapiye bağlı şiddetli sistemik reaksiyonların geç dönemde nadir de olsa görülebileceğini vurgulamak istedik.

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Cite This Article

ŞENBABA, E., ÇATAL, F., TOPAL, E., ERMİŞTEKİN, H., YILDIRIM, N., SİNANOĞLU, M. S. (2013). Delayed severe systemic reaction (anaphylaxis) after subcutaneous immunotherapy injections: Case report. Astım Allerji İmmünoloji, Cilt: 11 - Sayı: 3, 204–207. https://ajindex.com/articles/156472

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References (13)

  1. Cox L, Nelson H, Lockey R, Calabria C, Chacko T, Finegold I, et al. Allergen immunotherapy: a practice parameter third update. J Allergy Clin Immunol 2011;127(Suppl 1):S1-S55
  2. Greineder DK. Risk management in allergen immunotherapy. J Allergy Clin Immunol 1996;98(6 Pt 3):S330- S4
  3. Larenas-Linnemann D. Subcutaneous and sublingual immunotherapy in children: complete update on controversies, dosing, and efficacy. Curr Allergy Asthma Rep 2008;8:465-74
  4. Des Roches A, Paradis L, Menardo JL, Bouges S, Daures JP, Bousquet J. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol 1997;99: 450-3
  5. Pajno GB, Barberio G, De Luca F, Morabito L, Parmiani S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study. Clin Exp Allergy 2001;31:1392-7
  6. Inal A, Altintas DU, Yilmaz M, Karakoc GB, Kendirli SG, Sertdemir Y. Prevention of new sensitizations by specific immunotherapy in children with rhinitis and/ or asthma monosensitized to house dust mite. J Investig Allergol Clin Immunol 2007;17:85-91
  7. Eng PA, Reinhold M, Gnehm HP. Long-term efficacy of preseasonal grass pollen immunotherapy in children. Allergy 2002;57:306-12
  8. Jacobsen L. Preventive aspects of immunotherapy: prevention for children at risk of developing asthma. Ann Allergy Asthma Immunol 2001;87:43-6
  9. Cox L, Larenas-Linnemann D, Lockey RF, Passalacqua G. Speaking the same language: the World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System. J Allergy Clin Immunol 2010;125:569-74
  10. Tinkelman DG, Cole WQ 3rd, Tunno J. Immunotherapy: a one-year prospective study to evaluate risk factors of systemic reactions. J Allergy Clin Immunol 1995;95:8-14
  11. DaVeiga SP, Caruso K, Golubski S, Lang DM. A retrospective survey of systemic reaction from allergen immunotherapy. J Allergy Clin Immunol 2008;121 (Suppl):S124
  12. Winther L, Arnved J, Malling HJ, Nolte H, Mosbech H. Side-effects of allergen specific immunotherapy: a prospective multi-centre study. Clin Exp Allergy 2006;36: 254-60
  13. Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI. Immediate and delayed-onset systemic reactions after subcutaneous immunotherapy injections: ACA- AI/AAAAI surveillance study of subcutaneous immunotherapy: year 2. Ann Allergy Asthma Immunol 2011;107:426-31.