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Journals / International Journal of Chemistry and Technology / 2022 / Volume: 6 Issue: 2

Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract

Ramazan Erenler(Gaziosmanpasa University)0000-0002-0505-3190
Esma Nur Geçer(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0002-0095-079X
Büşra Moran Bozer(HITIT UNIVERSITY)0000-0002-7280-4417
Pages
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Publication Date
2022-12-31
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Consequently, AgNPs@Om may be a promising anticancer drug candidate.

📌 3 Key Takeaways

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Objective & Hypothesis:Anticancer activity of Origanum majorana extract and silver nanoparticles was investigated by MTT assay using human pancreatic adenocarcinoma cell lines (Capan-1), mouse normal fibroblast cell lines (L929), and human colon adenocarcinoma cell line (Caco-2).
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Key Findings & Data:AgNPs@Om exhibited the excellent cytotoxic effect on Capan-1 cell lines with the cell viability of 29.17% and 25.70%, 22.49%, 21.16% at 1.0, 0.5, 0.25, 0.125 μg/mL respectively.
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Conclusion & Impact:Consequently, AgNPs@Om may be a promising anticancer drug candidate.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Silver nanoparticles · natural products · Origanum majorana

Abstract

application. Anticancer activity of Origanum majorana extract and silver nanoparticles was investigated by MTT assay using human pancreatic adenocarcinoma cell lines (Capan-1), mouse normal fibroblast cell lines (L929), and human colon adenocarcinoma cell line (Caco-2). AgNPs@Om exhibited the excellent cytotoxic effect on Capan-1 cell lines with the cell viability of 29.17% and 25.70%, 22.49%, 21.16% at 1.0, 0.5, 0.25, 0.125 μg/mL respectively. However, the extract was determined to show moderate activity. A considerable fall in the viable cell number in Caco-2 cell lines was observed after the treatment of AgNPs@Om. The viable cells of Caco-2 cell lines were detected as 32.0% at 1.0 μg/mL with the treatment of nanoparticles. Yet, the viable Caco-2 cells were determined as 48.2% with the treatment of O. majorana extract. Both extract and nanoparticles had no impact on the viability of non-tumor cells (L929). Moreover, nanoparticles induced apoptosis. Consequently, AgNPs@Om may be a promising anticancer drug candidate.

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Cite This Article

Erenler, R., Geçer, E. N., Bozer, B. M. (2022). Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract. International Journal of Chemistry and Technology, Volume: 6 Issue: 2. https://doi.org/10.32571/ijct.1187754

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