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Journals / International Journal of Chemistry and Technology / 2023 / Volume: 7 Issue: 2

Comparison of thewound healing effects of vascular endothelial growth factor a (VEGF-A) and transforming growth factor beta 3 (TGF-β3) on gingival cells

Serkan Yelli(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0003-1938-1731
Aslı Yıldırım(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0001-5674-2095
Seçil Erden Tayhan(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0001-8473-5896
Sema Bilgin(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0001-5921-5434
İsa Gökçe(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0002-5023-9947
Pages
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Publication Date
2023-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result of the study, it was concluded that TGF-β3 and VEGF-A proteins are not cytotoxic and have a wound-healing effect on gingival fibroblast cells.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Each tissue has its own anatomy and physiology.
📊
Key Findings & Data:Since it is known that TGF-β3 and VEGF-A proteins which are among these cytokines, play an active role in wound healing stages.
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Conclusion & Impact:As a result of the study, it was concluded that TGF-β3 and VEGF-A proteins are not cytotoxic and have a wound-healing effect on gingival fibroblast cells.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:TGF-β3 · VEGF-A · Gingival fibroblast cells

Abstract

Each tissue has its own anatomy and physiology. The deterioration of these structures by various effects (crushing, puncture, pathogens, etc.) is called as wound. The tissue exposed to these effects wants to gain the same function and anatomy. This phenomenon is called wound healing. Wound healing is a process that involves many reactions and cytokines. Since it is known that TGF-β3 and VEGF-A proteins which are among these cytokines, play an active role in wound healing stages. In the present study, it was decided to examine the wound healing effects of the non human gingival fibroblast cells comperatively. Wound healing process under the influence of these cytokines was performed by in vitro scratch analysis which is known as easy, reliable and cheap technique. In this context, firstly cell viability analysis was performed to determine the most effective dose for inducing cell proliferation. After this experimental step, gingival cells were incubated for 72 hours with suitable TGF-β3 and VEGF-A doses. As a result of the study, it was concluded that TGF-β3 and VEGF-A proteins are not cytotoxic and have a wound-healing effect on gingival fibroblast cells.

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Cite This Article

Yelli, S., Yıldırım, A., Tayhan, S. E., Bilgin, S., Gökçe, İ. (2023). Comparison of thewound healing effects of vascular endothelial growth factor a (VEGF-A) and transforming growth factor beta 3 (TGF-β3) on gingival cells. International Journal of Chemistry and Technology, Volume: 7 Issue: 2. https://doi.org/10.32571/ijct.1249472

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