Journals / International Journal of Agriculture Forestry and Life Sciences / 2026 / Volume: 10 Issue: 1

Black mulberry (Morus nigra L.) fruits: A miracle from nature for human health

İrem Şemisdoğan(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ)0000-0002-5840-6041
Melike Urfalı(OSMANGAZİ ÜNİVERSİTESİ)0000-0002-6566-521X
Volkan Okatan(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ)0000-0001-5787-7573
Pages
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Publication Date
2026-05-22
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this sense, the black mulberry offers distinctive potential for innovation in modern food technology.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The black mulberry has a long and remarkable history, rediscovered today through the lens of modern scientific research.
📊
Key Findings & Data:Studies have demonstrated that the fruit’s strong antioxidant activity and anticarcinogenic potential, together with its protective effects on the immune system, make it an important functional food.
💡
Conclusion & Impact:In this sense, the black mulberry offers distinctive potential for innovation in modern food technology.
🔬Design:Review
📍Scope:Comprehensive Sample
⚙️Variables:Black mulberry · Morus nigra · health

Abstract

The black mulberry has a long and remarkable history, rediscovered today through the lens of modern scientific research. Its rich content of anthocyanins, antioxidants, vitamin C, and other bioactive substances plays a vital role in maintaining human health. Studies have demonstrated that the fruit’s strong antioxidant activity and anticarcinogenic potential, together with its protective effects on the immune system, make it an important functional food. Moreover, its supportive role in the treatment of cardiovascular and neurological disorders, and its healing effects on various skin and venereal diseases, add to its medical and nutritional significance. In addition, black mulberry shows promising anti-inflammatory and blood sugar–regulating effects. The compounds it contains are frequently involved in therapeutic approaches for conditions such as high cholesterol, hypertension, diabetes, and obesity. The natural pigments found in the fruit also serve as valuable raw materials for natural dye production used in woodcraft, furniture design, reed manufacturing, and textile industries. Owing to its well-balanced sweet and sour taste, the fruit is appreciated fresh but is also processed into jams, wines, vinegars, dried fruits, and juices, appearing on dining tables in many different forms. The black mulberry tree, which affects the quality of silk, carries an ancient heritage that extends from East to West, bridging the past with the present. Beyond its contribution to human well-being, the tree indirectly influences the immune system of silkworms, thereby improving the sheen and texture of silk. This interaction helps sustain a long-standing cultural and economic tradition. When a ripe mulberry is picked, it immediately reveals the natural aroma and nutritional richness bestowed by its environment. Yet, because the fruit has a very short shelf life, it must be consumed rapidly or processed into other durable products. For this reason, careful attention to storage and post-harvest processing is essential to maintain quality and enhance its market value. In this sense, the black mulberry offers distinctive potential for innovation in modern food technology.

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Cite This Article

Şemisdoğan, İ., Urfalı, M., Khaliq, G., Asanica, A., Okatan, V. (2026). Black mulberry (Morus nigra L.) fruits: A miracle from nature for human health. International Journal of Agriculture Forestry and Life Sciences, Volume: 10 Issue: 1. https://doi.org/10.66598/ijafls.1898045

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References (77)

  1. Agarwal S, Mohamed MS, Raveendran S. (2018). Formulation, Char-Acterization and Evaluation of Morusin Loaded Niosomes for Poten-Tiation of Anticancer Therapy. RSC Adv. 57: 32621-32636
  2. Ahlawat, T., Patel, N. L., Agnihotri, R., Patel, C. R., & Tandel, Y. (2016). Black Mulberry (Morus Nigra). Underutilized Fruit Crops: Importance And Cultivation, 195, 212.
  3. Alakbarov, F., Aliyev, I. 2000. Silk Road-The Origin of The Mulberry Trees. Azerbaijan International, 8: 3.
  4. Alighieri, D. (2022). ‘Vegetable-but-nonetheless-human life:’Allegories of Arborical Transformation in Ovid, Virgil, and Dante Alighieri, 2-8.
  5. Aly Maher Arafa, N. (2021). Utilization Of Egyptian Mulberry in Manufacture of Some High Nutritional Value Products. Int. J. Food Sci. Nutr. Heal. Fam. Stud., 2, 1–19.
  6. Ayvaz, H.; Cabaroglu, T.; Akyildiz, A.; Pala, C.U.; Temizkan, R.; Agçam, E.; Ayvaz, Z.; Durazzo, A.; Lucarini, M.; Direito, R. (2023) Anthocyanins: Metabolic Digestion, Bioavailability, Therapeutic Effects, Current Pharmaceutical/Industrial Use, And Innovation Potential. Antioxidants.12, 48.
  7. Baci G-M, Baciu E-D, Cucu A-A. (2023) Sericultural by-products: thepotential for alternative therapy in cancer drug design [J/OL]. Molecules. 28(2):850.
  8. Bang SI, Kim HY, Seo WT. (2022). Mulberry Vinegar Attenuates Lipopolysaccharide and Interferon Gamma-Induced Inflammatory Responses in C6 Glial Cells. J Food Biochem;46(8): e14197.
  9. Baytop, T. (1999). Türkiye’de Bitkilerle Tedavi. İstanbul Eczacılık Fakültesi Yayınları, 2,4.
  10. Bhanja Dey T, Chakraborty S, Jain KK. (2016). Antioxidant Phenolics and Their Microbial Production by Submerged and Solid-State Fermentation Process: A Review. Trends Food Sci Technol.; 53:60-74.
  11. Bown, D. (1995). Encyclopadia Of Herbs and Their Uses, Dorling Kindersley, London, U.K.
  12. Browicz, K. (2000). Where Is the Place of Origin of Morus Nigra (Moraceae)? In Fragmenta Floristica Et Geobotanica 45:1-2 273-280.
  13. Bumrungpert, A.; Lilitchan, S.; Tuntipopipat, S.; Tirawanchai, N.; Komindr, S. (2018). Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, And Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients, 10, 713.
  14. Calin-Sánchez, A., Martinez-Nicolás, J.J, Munera-Picazo, S., Carbonell-Barrachina, A.A., Legua, P. And Hernández, F. (2013). Bioactive Compounds and Sensory Quality of Black and White Mulberries Grown in Spain. Plant Foods Hum Nutr., 68(4):370-377.
  15. Chaiwong S, Chatturong U, Chanasong R, (2021). Dried Mulberry Fruit Ameliorates Cardiovascular and Liver Histopathological Changes in High-Fat Diet-Induced Hyperlipidemic Mice. J Tradit Complement Med. 11(4):356-368.
  16. Chanoca, A.; Kovinich, N.; Burkel, B.; Stecha, S.; Bohorquez-Restrepo, A.; Ueda, T.; Eliceiri, K.W.; Grotewold, E.; Otegui, M.S.(2015). Anthocyanin Vacuolar Inclusions Form By A Microautophagy Mechanism. Plant Cell 27, 2545–2599.
  17. Chen, P.N., Chu, S.C., Chiou, H.L., Kuo, W.H., Chiang, C.L., Hsieh, Y.S. (2006). Mulberry Anthocyanins, Cyanidin 3-Rutinoside and Cyanidin 3-Glucoside, Exhibited an Inhibitory Effect on The Migration and Invasion of A Human Lung Cancer Cell Line. Cancer Lett, 235: 248–259.
  18. Coles, P. (2019). Mulberry Reaktion Books.
  19. Cooper, D.; Doucet, L.; Pratt, M. (2007). Influence Of Cultivar, Conventional and Organic Agricultural Practices on Phenolic and Sensory Profile of Blackberries (Rubus Fruticosus). J. Organ. Behav., 28, 303–325.
  20. De Candolle A. (1967). Origin of Cultivated Plants. New York and London, 149-153.
  21. Du H, Wang X, Yang H. (2022). Changes Of Phenolic Profile and Antioxidant Activity During Cold Storage of Functional Flavored Yogurt Supplemented with Mulberry Pomace. Food Control. 132:108554.
  22. Ercisli, S. (2004). Ashort Review Ofthe Fruit Germplasmresources of Turkey. Genet.Res.Crop Evol., 51: 419–435.
  23. Erdem S. (2022). Farklı Kanser Tipleri Üzerinde Morusnigraeksozomlarınınanti-Kanser Etkisi.Yüksek Lisans Tezi. Fırat Üniversitesi Fen Bilimleri Enstitüsü Biyoteknoloji Anabilim Dalı, Elazığ.
  24. Fakhree, M.A.B., Nazemiyeh, H. (2011). Are Anthocyanins and Flavanoids Responsible for The Blood Pressure Lowering Effect and Antiplatelet Activity of Morus Nigra. Biomedicine International, 2: 97-98.
  25. Fallah S, Hajihassan Z, Zarkar N. (2018). Evaluation Of Anticanceractivity of Extracted flavonoids From Morus Alba Leaves and Itsinteraction With DNA. Braz Arch Biol Technol.;61:e18160623.
  26. Fang, S.H., Hou, Y.C. and Chao, P.D. (2005). Pharmacokinetic And Pharmacodynamic Interactions Ofmorin and Cyclosporin. Toxicol. Appl. Pharmacol., 205: 65-70.
  27. Gonçalves, A.C.; Bento, C.; Silva, B.; Simões, M.; Silva, L.R. (2019). Nutrients, Bioactive Compounds and Bioactivity: The Health Benefits Of Sweet Cherries (Prunus Avium L.). Curr. Nutr. Food Sci., 15, 208–227.
  28. Grieve, M. (1931). A Modern Herbal Jonathan Cape, Botanical.com [online version the original book] (accessed 2021-12-03)
  29. Gundogdu, M., Muradoglu, F., Gazioglu Sensoy, R.I., Yilmaz,H. (2011). Determination Of Fruit Chemical Properties of Morus Nigra L., Morus Alba L. And Morus Rubra L. By HPLC. Sci. Hortic., 132: 37-41.
  30. Gürcan, K. (2021). Ekşi Karadutun (Morus Nigra L.) Türkiye’de Yetiştiricilik Kültürü ve Alanları: Asırlık Ağaçların Keşfi. Avrupa Bilim Ve Teknoloji Dergisi(31), 568-582.
  31. Hassimotto, N.M.A., Genovese, M.I., Lajolo, F.M. (2007). Identification And Characterization of Anthocyanins Fromwild Mulberry (Morus Nigra L.) Growing In Brazil. Food Sci. Technol. Int., 13: 17-25. He Y, Liu G, Xia C.(2022). Laxative Effect Of Mulberry Ferment On Two Models Of Constipated Mice. J Funct Foods;90:104971.
  32. Hu J, Vinothkanna A, Wu M. (2021). Tracking The Dynamic Changes Of A Flavor, Phenolic Profile, And Antioxidant Properties Of Lactiplantibacillus Plantarum- And Saccharomyces Cerevisiaefermented Mulberry Wine. Food Sci Nutr. 9(11):6294-6306.
  33. Hu, W.; Sarengaowa; Guan, Y.; Feng, K. (2022). Biosynthesis Of Phenolic Compounds And Antioxidant Activity In Fresh-Cut Fruits And Vegetables. Front. Microbiol.13, 906069.
  34. Huang H.-P., Chang Y.-C., Wu C.-H., Hung C.-N., Wang C.-J. ( 2011). Anthocyanin-Rich Mulberry Extract Inhibit The Gastric Cancer Cell Growth In Vitro And Xenograft Mice By Inducing Signals Of P38/P53 And C-Jun. Food Chem.; 129:1703–1709.
  35. Huang HP, Ou TT, Wang CJ. (2013). Mulberry And Its Bio-Active Compounds, The Chemoprevention Effects And Molecular Mechanisms In Vitro And In Vivo. J Tradit Complement Med;3(1):7-15
  36. Jiang, Y.; Nie,W.J. (2015). Chemical Properties In Fruits Of Mulberry Species From The Xinjiang Province Of China. Food Chem., 174,
  37. Khoo HE, Azlan A, Tang ST, Lim S.M. (2017). Anthocyanidins And Anthocyanins: Colored Pigments As Food, Pharmaceutical Ingredients, And The Potential Health Benefits. Food Nutr Res 61(1):1361779.
  38. Kostic, D.A., Dimitrijevic, D.S., Mitic, S.S., Mitic, M.N., Stojanovic, G.S., Zivanovic, A., (2013). A Survey On Macro- And Micro-Elements, Phenolic Compounds, Biological Activity And Use Of Morus Spp. (Moraceae). Fruits, 68: 333-347.
  39. Kostic, E., Arsic, B., Mitic, M., Dimitrijevic, D., Marinkovic, E.P. (2019). Optimization Of The Solid-Liquid Extraction Process Of Phenolic Compounds From Mulberry Fruit. Not Bot Horti Sagrobo, 47(3): 629–633
  40. Koyuncu, F., Senel, E. (2003). Rooting Of Black Mulberry (Morus Nigra L.) Hardwood cuttings.
  41. Kumar, N.; Goel, N.(. 2019). Phenolic Acids: Natural Versatile Molecules With Promising Therapeutic Applications. Biotechnol. Rep, 24, E00370
  42. Kutlu, T., Durmaz, G., Ateş, B., Yılmaz, İ., Çetin, M.Ş. (2011). Antioxidant Properties Of Different Extracts Of Black Mulberry (Morus Nigra L.). Turk J Biol, 35: 103–110.
  43. Lale H. (1992). Dut Türlerinin Pomolojik, Fenolojik Ve Meyve Kalite Özellikleri Üzerine Bir Çalışma. Yüksek Lisans Tezi, Ege Üniversitesi, İzmir.
  44. Lim H.H., Lee S.O., Kim S.Y., Yang S.J., Lim Y. (2013). Anti-Inflammatory And Antiobesity Effects Of Mulberry Leaf And Fruit Extract On High Fat Diet-Induced Obesity. Exp. Biol. Med;238:1160–1169.
  45. Lim SH, Choi C-I. (2019). Pharmacological Properties Of Morus Nigra L. (Black Mulberry) As A Promising Nutraceutical Resource. Nutrients 11(2):437.
  46. Linnaeus, C. (1753). Species Plantarum Laurentius Salvius, Stockholm.
  47. Mahesh, D.S., Vidhathri, B.S., Vidyashree, D.N., Narayanaswamy, T.K., Subbarayappa, C.T., Muthuraju, R. (2017). Biochemical Composition and Pharmacological Properties of Mulberry (Morus spp.) - A Review. Int J Curr Microbiol Appl Sci, 6(7): 2207–2217.
  48. Mirzabe AH, Hajiahmad A. (2022). Filter Press Optimisation For Black Mulberry Juice Extraction. Biosystems Eng;215:80-103.
  49. Nguyen LTH. (2022). Biological Activities Of Paper Mulberry (Broussonetiapapyrifera): More Than A Skin-Lightening Agent. Cosmetics.;9(6): 112. Biological Activities Of Paper Mulberry (Broussonetiapapyrifera): More Than A Skin-Lightening Agent. Cosmetics.;9(6):112.
  50. Nowak, R.; Olech, M.; Nowacka, N. (2013). Plant Polyphenols As Chemopreventive Agents. Polyphen. Hum. Health Dis., 2, 1289–1307.
  51. Okatan, V. (2018). Phenolic Compounds and Phytochemicals In Fruits Of Black Mulberry (Morus Nigra L.) Genotypes From The Aegean Region In Turkey. Folia Hortic, 30, 93–101.
  52. Ottman Y. (1987). Rediscovering The Realm Of Fruitingmulberry Varieties. Fruit Varieties Journal, 41(1): 4–7.
  53. Ovando, A.C., Hernandez, L.P., Hernandez, M.E.P., Rodriguez, J.A., Vidal, C.A.G. (2009). Chemical Studies Of Anthocyanins: A Review. Food Chem, 113: 859–871.
  54. Paredes-López, O.; Cervantes-Ceja, M.L.; Vigna-Pérez, M.; Hernández-Pérez, T.(2010). Berries: Improving Human Health And Healthy Aging, And Promoting Quality Life- A Review. Plant Foods Hum. Nutr. 65, 299–308.
  55. Pinheiro, C.; Wienkoop, S.; de Almeida, J.F.; Brunetti, C.; Zarrouk, O.; Planchon, S.; Gori, A.; Tattini, M.; Ricardo, C.P.; Renaut, J.( 2019). Phellem Cell-Wall Components Are Discriminants Of Cork Quality In Quercus Suber. Front. Plant Sci., 10, 1–15.
  56. Polumackanycz M, Sledzinski T, Goyke E. (2019). A Comparative Study On The Phenolic Composition And Biological Activities Of Morus Alba L. Commercial Samples. Molecules.;24(17):3082.
  57. Schulz, M.; Seraglio, S.K.T.; Della Betta, F.; Nehring, P.; Valese, A.C.; Daguer, H.; Gonzaga, L.V.; Costa, A.C.O.; Fett, R. ( 2019). Blackberry (Rubus Ulmifolius Schott): Chemical Composition, Phenolic Compounds And Antioxidant Capacity In Two Edible Stages. Food Res. Int., 122, 627–634
  58. Sellappan S.; Akoh, C.C.; Krewer, G. (2002). Phenolic Compounds And Antioxidant Capacity Of Georgia-Grown Blueberries And Blackberries. J. Agric. Food Chem., 50, 2432–2438.
  59. Sheikh S, Siddique F, Ameer K. (2023). Effects Of White Mulberry Powder Fortification On Antioxidant Activity, Physicochemical, Microbial And Sensorial Properties Of Yogurt Produced From Buffalo Milk. Food Sci Nutr.;11(1):204-215.
  60. Shekarabi, S.P.H., Omidi, A.H., Dawood, M.A.O., Adel, M., Avazeh, A., Heidari, F. (2020). Effect Of Black Mulberry (Morus Nigra) Powder On Growth Performance, Biochemical Parameters, Blood Carotenoid Concentration, And Fillet Color Of Rainbow Trout. Ann Anim Sci, 20(1): 125–136.
  61. Shukla, R.K., Painuly, D., Singh, J., Porval, A. and Vats S. (2014). In Vitro Biological Activity Andtotal Phenolic Content Of Morusnigra Seeds. Journal Ofchemical Andpharmaceutical Research, 6(11): 200-210.
  62. Soltanikazemi M, Abdanan Mehdizadeh S, Heydari M. ( 2023). Development Of A Smart Spectral Analysis Method For The Determination Of Mulberry (Morus Alba Var. Nigra L.) Juice Quality Parametersusing FT-IR Spectroscopy. Food Sci Nutr.;11(4):1808-1817.
  63. Suh, HJ, Noh, DO, Kang, CS, Kim, JM, Lee, SW. (2003). Thermal Kinetics Of Color Degradation Of Mulberry Fruit Extract. Nahrung/Food, 47(2): 132– 135.
  64. Thukham-Mee W, Wattanathorn J, Paholpak P. (2021). The Positive Modulation Effect Of A 6-Week Consumption Of An Anthocyaninrich Mulberry Milk On Working Memory, Cholinergic, And Monoaminergic Functions In Healthy Working-Age Adults. Oxid Med CellNLongevity2021:5520059.
  65. Tomas, M., Toydemir, G., Boyacioglu, D., Hall, R.D., Beekwilder, J. and Capanoglu, E. (2017), Processing Black Mulberry Into Jam: Effects On Antioxidant Potential And In Vitro Bioaccessibility. J. Sci. Food Agric, 97: 3106-3113.
  66. Trung NQ, Luyen NT, Nam VD. (2018). Chemical composition and in vitro biological activities of white mulberry syrup during processing and storage. J Food Nutr Res.;6(10):660-664.
  67. Vega, E.N.; Molina, A.K.; Pereira, C.; Dias, M.I.; Heleno, S.A.; Rodrigues, P.; Fernandes, I.P.; Barreiro, M.F.; Stojkovi´c, D.; Sokovi´c, M. (2021). Anthocyanins From Rubus Fruticosus L. And Morus Nigra L. Applied As Food Colorants: A Natural Alternative. Plants, 10, 1181.
  68. Wang, R.S.; Dong, P.H.; Shuai, X.X.; Chen, M.S. (2022). Evaluation Of Different Black Mulberry Fruits (Morus Nigra L.) Based On Phenolic Compounds And Antioxidant Activity. Foods 11, 1252.
  69. Wang,Q., Xu, J., Rottinghaus,G.E., Simonyi,A., Lubahn, D., Sun,G.Y. and Sun, A.Y. (2002). Resveratrol Protects Against Global Cerebral Ischemic Injury In Gerbils. Brainres., 958: 439–447.
  70. Yaltırık, F., Efe, A., (1994). Dendroloji Ders Kitabı. İstanbul Üniversitesi Orman FakültesiYayın No: 3836–43, İstanbul, 382 s.
  71. Zhan, L, Chen, Q, Chen, Z. (2024). Anti-Skinagingeffectsofmulberryfruit Extracts: In Vitro And In Vivo Evaluations Of The Anti-Glycation Andantioxidant Activities. J Funct Foods.;112:105984.
  72. Bang SI, Kim HY, Seo WT. (2022). Mulberry Vinegar Attenuates Lipopolysaccharide and Interferon Gamma-Induced Inflammatory Responses in C6 Glial Cells. J Food Biochem;46(8): e14197.
  73. Hassimotto, N.M.A., Genovese, M.I., Lajolo, F.M. (2007). Identification And Characterization of Anthocyanins Fromwild Mulberry (Morus Nigra L.) Growing In Brazil. Food Sci. Technol. Int., 13: 17-25. He Y, Liu G, Xia C.(2022). Laxative Effect Of Mulberry Ferment On Two Models Of Constipated Mice. J Funct Foods;90:104971.
  74. Huang HP, Ou TT, Wang CJ. (2013). Mulberry And Its Bio-Active Compounds, The Chemoprevention Effects And Molecular Mechanisms In Vitro And In Vivo. J Tradit Complement Med;3(1):7-15
  75. Kumar, N.; Goel, N.(. 2019). Phenolic Acids: Natural Versatile Molecules With Promising Therapeutic Applications. Biotechnol. Rep, 24, E00370
  76. Nguyen LTH. (2022). Biological Activities Of Paper Mulberry (Broussonetiapapyrifera): More Than A Skin-Lightening Agent. Cosmetics.;9(6): 112. Biological Activities Of Paper Mulberry (Broussonetiapapyrifera): More Than A Skin-Lightening Agent. Cosmetics.;9(6):112.
  77. Vega, E.N.; Molina, A.K.; Pereira, C.; Dias, M.I.; Heleno, S.A.; Rodrigues, P.; Fernandes, I.P.; Barreiro, M.F.; Stojkovi´c, D.; Sokovi´c, M. (2021). Anthocyanins From Rubus Fruticosus L. And Morus Nigra L. Applied As Food Colorants: A Natural Alternative. Plants, 10, 1181.