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Journals / Black Sea Journal of Health Science / 2026 / Cilt: 8 Sayı: 1

Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression

Burcu Bayyurt(SİVAS CUMHURİYET ÜNİVERSİTESİ)0000-0002-5618-457X
Pages
17–20
Publication Date
2025-01-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Long non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs).
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Key Findings & Data:Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer.
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Conclusion & Impact:It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Hepatocellular carcinoma associated transcript 1 · Oxidized low-density lipoprotein · Gene expression

Abstract

Long non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs). Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein (ox-LDL) is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells (HUVECs) treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction (qPCR) method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL (P<0.001). It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).

Özet

Long non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs). Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein (ox-LDL) is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells (HUVECs) treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction (qPCR) method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL (P<0.001). It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).

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Cite This Article

Bayyurt, B. (2025). Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression. Black Sea Journal of Health Science, Cilt: 8 Sayı: 1, 17–20. https://doi.org/10.19127/bshealthscience.1588660

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