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Journals / Black Sea Journal of Health Science / 2026 / Cilt: 9 Sayı: 5

The Role of Plants Belonging to the Lamiaceae Family in Tissue Regeneration and Wound Healing: Phytochemical, Biochemical, and Molecular Mechanisms

Lamiaceae Familyasına Ait Bitkilerin Doku Rejenerasyonu ve Yara İyileşmesindeki Rolü: Fitokimyasal, Biyokimyasal ve Moleküler Mekanizmalar

Veysel Ağan(HARRAN UNIVERSITY)0000-0003-0702-6249
Pages
204–213
Publication Date
2026-09-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The data obtained indicate that the Lamiaceae family has significant therapeutic potential in terms of natural wound care products and biotechnological wound treatment applications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Tissue regeneration is a complex biological process consisting of hemostasis, inflammation, proliferation, and remodeling phases.
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Key Findings & Data:In recent years, there has been increased interest in the therapeutic potential of naturally occurring bioactive compounds in tissue regeneration, with particular attention given to medicinal and aromatic plants belonging to the Lamiaceae family.
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Conclusion & Impact:The data obtained indicate that the Lamiaceae family has significant therapeutic potential in terms of natural wound care products and biotechnological wound treatment applications.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Lamiaceae · Doku rejenerasyonu · Oksidatif stres

Abstract

Tissue regeneration is a complex biological process consisting of hemostasis, inflammation, proliferation, and remodeling phases. Factors such as oxidative stress, microbial infections, and uncontrolled inflammation can negatively affect tissue regeneration. In recent years, there has been increased interest in the therapeutic potential of naturally occurring bioactive compounds in tissue regeneration, with particular attention given to medicinal and aromatic plants belonging to the Lamiaceae family. Species such as Salvia officinalis, Thymus vulgaris, Origanum vulgare, Mentha piperita, Lavandula angustifolia, and Rosmarinus officinalis, belonging to this family, are considered rich biological resources in terms of phenolic acids, flavonoids, terpenoids, and essential oil components. The effects of plants belonging to the Lamiaceae family on tissue regeneration occur through antioxidant, anti-inflammatory, antimicrobial, and regenerative mechanisms. It has been reported that bioactive compounds such as rosmarinic acid, thymol, carvacrol, menthol, and linalool suppress reactive oxygen species, reduce pro-inflammatory cytokine production, and exhibit inhibitory effects against various microbial pathogens. Furthermore, these compounds are said to accelerate tissue regeneration by supporting fibroblast proliferation, collagen synthesis, angiogenesis, and epithelialization processes. In addition, they are reported to have regulatory effects on cellular signaling pathways and growth factors. This review evaluates the biological effects of plants belonging to the Lamiaceae family on tissue regeneration in light of current literature data; their antioxidant capacity, inflammation modulation, antimicrobial activity, collagen biosynthesis, and mechanisms affecting tissue regeneration are examined. The data obtained indicate that the Lamiaceae family has significant therapeutic potential in terms of natural wound care products and biotechnological wound treatment applications.

Özet

Doku Rejenerasyonu; hemostaz, inflamasyon, proliferasyon ve yeniden şekillenme fazlarından oluşan kompleks bir biyolojik süreçtir. Oksidatif stres, mikrobiyal enfeksiyonlar ve kontrolsüz inflamasyon gibi faktörler doku rejenerasyonunu olumsuz etkileyebilmektedir. Son yıllarda doğal kaynaklı biyoaktif bileşiklerin doku rejenerasyonundaki terapötik potansiyeline yönelik ilgi artmış olup, özellikle Lamiaceae familyasına ait tıbbi ve aromatik bitkiler dikkat çekmektedir. Bu familyada yer alan Salvia officinalis, Thymus vulgaris, Origanum vulgare, Mentha piperita, Lavandula angustifolia ve Rosmarinus officinalis gibi türler; fenolik asitler, flavonoidler, terpenoidler ve uçucu yağ bileşenleri bakımından zengin biyolojik kaynaklar olarak değerlendirilmektedir. Lamiaceae familyasına ait bitkilerin doku rejenerasyonu üzerindeki etkileri; antioksidan, antiinflamatuvar, antimikrobiyal ve rejeneratif mekanizmalar üzerinden gerçekleşmektedir. Rosmarinik asit, timol, karvakrol, mentol ve linalool gibi biyoaktif bileşiklerin reaktif oksijen türlerini baskıladığı, proinflamatuvar sitokin üretimini azalttığı ve çeşitli mikrobiyal patojenlere karşı inhibitör etki gösterdiği bildirilmektedir. Ayrıca bu bileşiklerin fibroblast proliferasyonu, kolajen sentezi, anjiyogenez ve epitelizasyon süreçlerini destekleyerek doku yenilenmesini hızlandırdığı ifade edilmektedir. Bunun yanında hücresel sinyal yolları ve büyüme faktörleri üzerinde düzenleyici etkiler oluşturduğu belirtilmektedir. Bu derlemede, Lamiaceae familyasına ait bitkilerin doku rejenerasyonu üzerine biyolojik etkileri güncel literatür verileri doğrultusunda değerlendirilmiş; antioksidan kapasite, inflamasyon modülasyonu, antimikrobiyal aktivite, kolajen biyosentezi ve doku rejenerasyonu üzerindeki mekanizmaları incelenmiştir. Elde edilen veriler, Lamiaceae familyasının doğal yara bakım ürünleri ve biyoteknolojik yara tedavi uygulamaları açısından önemli bir terapötik potansiyel taşıdığını göstermektedir.

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Cite This Article

Ağan, V. (2026). The Role of Plants Belonging to the Lamiaceae Family in Tissue Regeneration and Wound Healing: Phytochemical, Biochemical, and Molecular Mechanisms. Black Sea Journal of Health Science, Cilt: 9 Sayı: 5, 204–213. https://doi.org/10.19127/bshealthscience.1952832

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