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Dergiler / Black Sea Journal of Health Science / 2026 / Cilt: 8 Sayı: 1

Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression

Burcu Bayyurt(SİVAS CUMHURİYET ÜNİVERSİTESİ)0000-0002-5618-457X
Sayfa
17–20
Yayın Tarihi
2025-01-15
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Long non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs).
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Temel Bulgular & Veri:Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer.
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Sonuç & Katkı:It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Hepatocellular carcinoma associated transcript 1 · Oxidized low-density lipoprotein · Gene expression

Özet

Long non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs). Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein (ox-LDL) is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells (HUVECs) treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction (qPCR) method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL (P<0.001). It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).

Abstract

Long non-coding RNAs (lncRNAs) have multiple biological functions in the vascular system including in endothelial cells (ECs). Hepatocellular carcinoma associated transcript 1 (HULC) is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein (ox-LDL) is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells (HUVECs) treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction (qPCR) method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL (P<0.001). It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases (CVDs).

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Bu Makaleye Atıf Yap

Bayyurt, B. (2025). Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression. Black Sea Journal of Health Science, Cilt: 8 Sayı: 1, 17–20. https://doi.org/10.19127/bshealthscience.1588660

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