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Journals / Balıkesir Sağlık Bilimleri Dergisi / 2026 / Volume: 13 Issue: 2

Determination of Paraoxonase 1 Activity and Phenotype Distribution in Cervical Disk Herniation Patients

Utku Adilay(BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, BEYİN VE SİNİR CERRAHİSİ ANABİLİM DALI)0000-0003-4867-244X
Salim Katar(BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, BEYİN VE SİNİR CERRAHİSİ ANABİLİM DALI)0000-0002-8311-1122
Kübra Çıkrıkcı(BALIKESİR ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, KİMYA BÖLÜMÜ, BİYOKİMYA ANABİLİM DALI)0000-0003-2276-1516
Nahit Gençer(BALIKESİR ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, KİMYA BÖLÜMÜ, BİYOKİMYA ANABİLİM DALI)0000-0001-7092-8857
Pages
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Publication Date
2024-08-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Keywords: Cervical disk herniation, Paraoxonase, Phenotype, PON1

📌 3 Key Takeaways

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Objective & Hypothesis:Determination of Paraoxonase 1 Activity and Phenotype Distribution in Cervical Disk Herniation Patients Abstract Objectives: Cervical disk herniation (CDH) is a common disease that usually develops as a result of intervertebral disk degeneration (IVDD) or trauma, which can cause pain or neurological deficiency by nevre root or spinal cord compression.
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Key Findings & Data:Paraoxonase 1 (PON1) has antioxidant qualities, and its function may vary based on genetic variations and ethnic background.
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Conclusion & Impact:Keywords: Cervical disk herniation, Paraoxonase, Phenotype, PON1
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Cervical disk herniation · Paraoxonase · Phenotype

Abstract

Determination of Paraoxonase 1 Activity and Phenotype Distribution in Cervical Disk Herniation Patients Abstract Objectives: Cervical disk herniation (CDH) is a common disease that usually develops as a result of intervertebral disk degeneration (IVDD) or trauma, which can cause pain or neurological deficiency by nevre root or spinal cord compression. Paraoxonase 1 (PON1) has antioxidant qualities, and its function may vary based on genetic variations and ethnic background. This study aims to compare PON1 activity and phenotype distribution in CDH patients and individuals without the condition. Materials and Methods: This study involved 70 CDH patients and 70 individuals in good health. Spectrophotometric tests were conducted to measure the serum PON1 and arylesterase (ARE) activities. The PON1 ratio, which indicates the salt-stimulated PON/ARE level, showed a three-peak distribution. This ratio was utilized to determine the various phenotypes; QQ, QR, and RR for each participant. Results: The PON1 activity was lower in CDH patients compared to the healthy individuals (p < 0.05). CDH patients exhibited a statistically significant QQ phenotype in comparison to the healthy participants (p < 0.05). Conclusion: Patients with CDH exhibited significantly reduced PON1 activity, indicating that low PON1 activity and the PON1 QQ phenotype could potentially be a risk factor for the development of CDH. Keywords: Cervical disk herniation, Paraoxonase, Phenotype, PON1

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Cite This Article

Adilay, U., Katar, S., Çıkrıkcı, K., Gençer, N. (2024). Determination of Paraoxonase 1 Activity and Phenotype Distribution in Cervical Disk Herniation Patients. Balıkesir Sağlık Bilimleri Dergisi, Volume: 13 Issue: 2. https://doi.org/10.53424/balikesirsbd.1403834

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