Journals / Balıkesir Sağlık Bilimleri Dergisi / 2026 / Volume: 15 Issue: 3

The Effect of Age and Regular Physical Activity on Body Composition, Blood Parameters, and Cardiovascular Risks in Adult Males and Females

Dilek Sevimli(Çukurova University)0000-0001-6463-1678
Mehmet Ziyagil(MERSİN ÜNİVERSİTESİ, SPOR BİLİMLERİ FAKÜLTESİ)0000-0000-0003-0984
Pages
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Publication Date
2026-10-08
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Sex specific physical activity recommendations and clinical risk assessment are needed.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study investigated the effects of gender, age (≤40 vs. >40 years), and regular physical activity on body composition (DEXA-measured), blood lipid profile (HDL, LDL, total cholesterol, triglycerides), and 10 year fatal cardiovascular risk (SCORE system) in 118 adults aged 30–60 years from Kayseri, Turkey.
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Key Findings & Data:Results: Men had significantly higher lean mass, bone mineral content, and triglycerides, while women had higher fat mass, body fat percentage, and HDL cholesterol (p 40 years showed significantly higher body weight, BMI, total and LDL cholesterol, fat mass, systolic blood pressure, and SCORE risk compared to younger women (d up to -2.607).
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Conclusion & Impact:Sex specific physical activity recommendations and clinical risk assessment are needed.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Physical activity · cardiovascular risk · body composition

Abstract

Objective: This study investigated the effects of gender, age (≤40 vs. >40 years), and regular physical activity on body composition (DEXA-measured), blood lipid profile (HDL, LDL, total cholesterol, triglycerides), and 10 year fatal cardiovascular risk (SCORE system) in 118 adults aged 30–60 years from Kayseri, Turkey. Methods: A cross sectional design was used. Participants were classified by sex, age group, and exercise stage (sedentary vs. regular exercisers) based on the Stages of Change Questionnaire. Body composition was assessed by dual energy X ray absorptiometry (DEXA). Blood lipids were measured from fasting samples. Cardiovascular risk was calculated using the SCORE algorithm. Independent t tests and Cohen’s d effect sizes were used for comparisons. Results: Men had significantly higher lean mass, bone mineral content, and triglycerides, while women had higher fat mass, body fat percentage, and HDL cholesterol (p 40 years showed significantly higher body weight, BMI, total and LDL cholesterol, fat mass, systolic blood pressure, and SCORE risk compared to younger women (d up to -2.607). Men >40 years had higher BMI, blood pressure and SCORE risk but no lipid changes. Regular exercise was associated with higher total and LDL cholesterol and higher 10 year SCORE risk in women (d=-0.543 to -0.668) but not in men. Exercise behaviour scores confirmed good adherence in the active groups. Conclusion: Age dramatically increases cardiovascular risk in both sexes, via lipid changes in women and blood pressure changes in men. The paradoxical elevations in cholesterol and SCORE risk in exercising women may reflect the “calcium paradox” (stable plaques) rather than true increased risk. Sex specific physical activity recommendations and clinical risk assessment are needed.

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Cite This Article

Sevimli, D., Erbaşı, F. Y., Ziyagil, M. (2026). The Effect of Age and Regular Physical Activity on Body Composition, Blood Parameters, and Cardiovascular Risks in Adult Males and Females. Balıkesir Sağlık Bilimleri Dergisi, Volume: 15 Issue: 3. https://doi.org/10.53424/balikesirsbd.1992392

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References (36)

  1. Aengevaeren, V. L., Mosterd, A., Braber, T. L., Prakken, N. H. J., Doevendans, P. A., Grobbee, D. E., Thompson, P. D., Eijsvoegels, T. M. H., & Velthuis, B. K. (2017). Relationship between lifelong exercise volume and coronary atherosclerosis in athletes. Circulation, 136(2), 138-148. https://doi.org/10.1161/CIRCULATIONAHA.117.027834
  2. Blake, G. M., & Fogelman, I. (2009). The clinical role of dual energy X ray absorptiometry. European Journal of Radiology, 71(3), 406–414. https://doi.org/10.1016/j.ejrad.2008.04.062 (düzeltildi)
  3. Büyüköztürk, Ş., Kılıç Çakmak, E., Akgün, Ö. E., Karadeniz, Ş., & Demirel, F. (2020). Bilimsel Araştırma Yöntemleri (28. baskı). Pegem Akademi.
  4. Cengiz, C. (2010). Physical activity and exercise stages of change levels of Middle East Technical University Students [Yayımlanmamış yüksek lisans tezi]. Orta Doğu Teknik Üniversitesi.
  5. Ching, S. M., Chia, Y. C., Lentjes, M. A. H., Luben, R., Wareham, N., & Khaw, K. T. (2019). FEV1 and total cardiovascular mortality and morbidity over an 18 years follow up population based prospective EPIC NORFOLK study. BMC Public Health, 19(1), 501. https://doi.org/10.1186/s12889-019-6818-x
  6. Conroy, R. M., Pyörälä, K., Fitzgerald, A. P., Sans, S., Menotti, A., De Backer, G., De Bacquer, D., Ducimetière, P., Jousilahti, P., Keil, U., Njølstad, I., Oganov, R. G., Thomsen, T., Tunstall Pedoe, H.,Tverdal, A., Wedel, H., Whincup, P., Wilhelmsen, L., & Graham, I. M. (2003). Estimation of ten year risk of fatal cardiovascular disease in Europe: The SCORE project. European Heart Journal, 24(11), 987 1003. https://doi.org/10.1016/s0195-668x(03)00114-3
  7. Craig, C. L., Marshall, A. L., Sjöström, M., Bauman, A. E., Booth, M. L., Ainsworth, B. E., Pratt, M., Ekelund, U., Yngve, A., Sallis, J. F., & Oja, P. (2003). International physical activity questionnaire: 12 country reliability and validity. Medicine & Science in Sports & Exercise, 35(8), 1381 1395. https://doi.org/10.1249/01.MSS.0000078924.61453.FB
  8. Çeker, A., Çekin, R., & Ziyagil, M. A. (2013). Farklı yaş gruplarındaki kadın ve erkeklerin düzenli fiziksel aktiviteye katılım davranışı değişim basamakları. CBÜ Beden Eğitimi ve Spor Bilimleri Dergisi, 8(1), 11 20. https://izlik.org/JA95WK97XA
  9. DeFina, L. F., Radford, N. B., Barlow, C. E., Willis, B. L., Leonard, D., Haskell, W. L., Farrell, S. W., Pavlovic, A., Abel, K., Berry, J. D., Khera, A., & Levine, B. D. (2019). Association of all cause and cardiovascular mortality with high levels of physical activity and concurrent coronary artery calcification. JAMA Cardiology, 4(2), 174 181. https://doi.org/ 10.1001/jamacardio.2018.4628
  10. Dunn, A. L., Marcus, B. H., Kampert, J. B., Garcia, M. E., Kohl III, H. W., & Blair, S. N. (1999). Comparison of lifestyle and structured interventions to increase physical activity and cardiorespiratory fitness: a randomized trial. JAMA, 281(4), 327 334. https://doi.org/10.1001/jama.281.4.327
  11. Dyrstad, S. M., Hansen, B. H., Holme, I. M., & Anderssen, S. A. (2014). Comparison of self reported versus accelerometer measured physical activity. Medicine & Science in Sports & Exercise, 46(1), 99 106. https://doi.org/10.1249/MSS.0b013e3182a0595f
  12. Ebem, Z. (2007). Health promoting behaviors and exercise stages of change levels of students at transition to university [Yayımlanmamış yüksek lisans tezi]. Orta Doğu Teknik Üniversitesi.
  13. Hamer, M., Ingle, L., Carroll, S., & Stamatakis, E. (2012). Physical activity and cardiovascular mortality risk: Possible protective mechanisms? Medicine & Science in Sports & Exercise, 44(1), 84 88. https://doi.org/10.1249/MSS.0b013e3182251077
  14. Hunter, S. K., Bhargava, S. S. A., Harper, A., & Hirschberg, J. (2023). The biological basis of sex differences in athletic performance: Consensus statement for the American College of Sports Medicine. Medicine & Science in Sports & Exercise, 55(12), 2328 2360. https://doi.org/10.1249/MSS.0000000000003300
  15. Janssen, I., Heymsfield, S. B., Wang, Z. M., & Ross, R. (2000). Skeletal muscle mass and distribution in 468 men and women aged 18 88 yr. Journal of Applied Physiology, 89(1), 81 88. https://doi.org/10.1152/jappl.2000.89.1.81
  16. Ji, H., Gulati, M., Huang, T. Y., Kwan, A. C., Ouyang, D., Ebinger, J. E., Casaletto, K., Moreau, K. L., Skali, H., & Cheng, S. (2024). Sex differences in association of physical activity with all cause and cardiovascular mortality. Journal of the American College of Cardiology, 83(8), 783-793. https://doi.org/10.1016/j.jacc.2023.12.019
  17. Marcus, B. H., & Simkin, L. R. (1993). The stages of exercise behavior. Journal of Sports Medicine and Physical Fitness, 33(1), 83 88.
  18. Marin Jimenez, N. B., Ruiz Montero, P. J., De la Flor Alemany, M., Aranda, P., & Aparicio, V. A. (2020). Association of objectively measured sedentary behavior and physical activity levels with health related quality of life in middle aged women: The FLAMENCO project. Menopause, 27(4), 437 443. https://doi.org/10.1097/GME.0000000000001494
  19. Marques, A., Santos, R., Ekelund, U., & Sardinha, L. B. (2015). Association between physical activity, sedentary time, and healthy fitness in youth. Medicine & Science in Sports & Exercise, 47(3), 575 580. https://doi.org/ 10.1249/MSS.0000000000000426
  20. Miçooğulları, B. O., Cengiz, C., Aşçı, F., & Kirazcı, H. (2010). Genç yetişkin bireylerin egzersiz öz yeterlik ve egzersize bakış açılarının cinsiyet ve egzersiz davranışı değişim basamaklarına göre incelenmesi. Spor Bilimleri Dergisi, 21(2), 49 59. https://doi.org/10.17644/sbd.171387
  21. Narkiewicz, K., Phillips, B. G., Kato, M., Hering, D., Bieniaszewski, L., & Somers, V. K. (2005). Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension, 45(4), 522-525. https://doi.org/10.1161/01.HYP.0000160318.46725.46
  22. Newman, A. B., Kupelian, V., Visser, M., Simonsick, E. M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., & Harris, T. B. (2006). Strength, but not muscle mass, is associated with mortality in the Health, Aging and Body Composition Study cohort. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61(1), 72 77. https://doi.org/10.1093/gerona/61.1.72
  23. Petek, B. J., Chung, E. H., Kim, J. H., Lampert, R., Levine, B. D., Phelan, D., & Baggish, A. L. (2023). Impact of sex on cardiovascular adaptations to exercise: JACC review topic of the week. Journal of the American College of Cardiology, 82(10), 1030 1038. https://doi.org/10.1016/j.jacc.2023.05.070
  24. Prospective Studies Collaboration. (2007). Blood cholesterol and vascular mortality by age, sex, and blood pressure: A meta analysis of individual data from 61 prospective studies with 55,000 vascular deaths. The Lancet, 370(9602), 1829 1839. https://doi.org/10.1016/S0140-6736(07)61778-4
  25. Reckelhoff, J. F. (2001). Gender differences in the regulation of blood pressure. Hypertension, 37(5), 1199-1208. Rifai, N., Horvath, A. R., & Wittwer, C. T. (2017). Tietz Textbook of Clinical Chemistry and Molecular Diagnostics: First South Asia Edition – E Book. Elsevier Health Sciences.
  26. Santos, B., Monteiro, D., Silva, F. M., Flores, G., Bento, T., & Duarte Mendes, P. (2024). Objectively measured physical activity and sedentary behaviour on cardiovascular risk and health related quality of life in adults: A systematic review. Healthcare, 12(18), 1866. https://doi.org/ 10.3390/healthcare12181866
  27. SenthilKumar, G., Katunaric, B., Bordas Murphy, H., Sarvaideo, J., & Freed, J. K. (2023). Estrogen and the vascular endothelium: The unanswered questions. Endocrinology, 164(6), bqad079. https://doi.org/10.1210/endocr/bqad079
  28. Singh, A. S., Chinapaw, M. J., Brug, J., Kremers, S. P., Visscher, T. L., & van Mechelen, W. (2009). Ethnic differences in BMI among Dutch adolescents: What is the role of screen viewing, active commuting to school, and consumption of soft drinks and high caloric snacks? International Journal of Behavioral Nutrition and Physical Activity, 6, 23. https://doi.org/10.1186/1479-5868-6-23
  29. Stanewicz, A. E., Wenner, M. M., & Stachenfeld, N. S. (2018). Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan. American Journal of Physiology Heart and Circulatory Physiology, 315(6), H1569 H1588. https://doi.org/10.1152/ajpheart.00396.2018
  30. Sung, D. E., & Sung, K. C. (2024). The paradox of physical activity and coronary arterial calcification: Implications for cardiovascular risk. Journal of Clinical Medicine, 13(21), 6523. https://doi.org/10.3390/jcm13216523
  31. Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J. M., Capodanno, D., Cosyns, B., Crawford, C., Davos, C. H., Desormais, I., Di Angelantonio, E., Franco, O. H., Halvorsen, S., Hobbs, F. D. R., Hollander, M.,. & Williams, B. (2021). 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. European Heart Journal, 42(34), 3227 3337. https://doi.org/10.1093/eurheartj/ehab484
  32. WHO. (2000). Obesity: Preventing and managing the global epidemic. Report of a WHO Consultation (WHO Technical Report Series 894). Geneva.
  33. Wilhite, K., Booker, B., Huang, B. H., Antczak, D., Corbett, L., Parker, P., Noetel, M., Rissel, C., Lonsdale, C., del Pozo Cruz, B., & Sanders, T. (2023). Combinations of physical activity, sedentary behavior, and sleep duration and their associations with physical, psychological, and educational outcomes in children and adolescents: A systematic review. American Journal of Epidemiology, 192(4), 665 679. https://doi.org/10.1093/aje/kwac212
  34. Williams, P. T., Haskell, W. L., Vranizan, K. M., & Krauss, R. M. (1995). The associations of high density lipoprotein subclasses with insulin and glucose levels, physical activity, resting heart rate, and regional adiposity in men with coronary artery disease: The Stanford Coronary Risk Intervention Project baseline survey. Metabolism, 44(1), 106 114. https://doi.org/10.1016/0026-0495(95)90296-1
  35. Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., & Lisheng, L. (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case control study. The Lancet, 364(9438), 937 952. https://doi.org/10.1016/S0140-6736(04)17018-9
  36. Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J. M., Capodanno, D., Cosyns, B., Crawford, C., Davos, C. H., Desormais, I., Di Angelantonio, E., Franco, O. H., Halvorsen, S., Hobbs, F. D. R., Hollander, M.,. & Williams, B. (2021). 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. European Heart Journal, 42(34), 3227 3337. https://doi.org/10.1093/eurheartj/ehab484