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Journals / Anatolian Current Medical Journal / 2026 / Volume: 7 Issue: 3

Investigation of salivary miRNA-199a-5p levels in plaque-induced gingivitis

Fatma Tuba Akdeniz(Istanbul Okan University, Faculty of Engineering and Naturel Sciences, Department of Genetics and Bioengineering, İstanbul.)0000-0002-6076-0509
Ahmet Mert Nalbantoğlu(Süleyman Demirel University Faculty of Dentistry Department of Periodontics Isparta)0000-0002-0505-867X
Zerrin Barut(Antalya Bilim University, Faculty of Dentistry, Department of Basic Medical Sciences, Antalya)0000-0002-6289-5562
Şule Bulut(Dr. Suat Gursel Kyrenia University Dentistry Hospital TRNC Kyrenia)0000-0002-8808-0185
Orçun Avşar(Hitit University, Faculty of Arts & Science, Department of Molecular Biology, Corum)0000-0003-3556-6218
Hilal Korkmaz Karadeniz(Antalya Oral and Dental Health Hospital)0000-0001-9886-5843
Turgay İsbir(Istanbul University, Aziz Sancar Experimental Medicine Research Institute, Department of Molecular Medicine, Retired Faculty Member, Istanbul, Turkey.)0000-0002-7350-6032
Pages
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Publication Date
2025-05-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although its role in autophagy and inflammation shows promise, further studies are needed to clarify its specific functions and clinical relevance.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aims: Epigenetic mechanisms play a crucial role in regulating the response to chronic inflammation in periodontal diseases and serve as reliable biomarkers.
📊
Key Findings & Data:Our study aims to investigate salivary miRNA-199a-5p levels in both healthy and diseased conditions and to evaluate its potential role as an early diagnostic indicator of periodontal diseases such as gingivitis.
💡
Conclusion & Impact:Although its role in autophagy and inflammation shows promise, further studies are needed to clarify its specific functions and clinical relevance.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:miRNA-199a-5p · gingivitis · periodontal disease

Abstract

Aims: Epigenetic mechanisms play a crucial role in regulating the response to chronic inflammation in periodontal diseases and serve as reliable biomarkers. While these biomarkers are traditionally assessed through invasive techniques, analyzing miRNA expression in saliva offers a non-invasive and convenient alternative. Our study aims to investigate salivary miRNA-199a-5p levels in both healthy and diseased conditions and to evaluate its potential role as an early diagnostic indicator of periodontal diseases such as gingivitis. Methods: Saliva samples from 50 individuals, either diagnosed with gingivitis or exhibiting a healthy periodontal condition, were analyzed using miRNeasy serum/plasma kit (Qiagen). SPSS software was used for statistical analysis. MiRNA-199a-5p expression levels were compared using the Mann-Whitney U test. Results: In saliva samples collected from 50 individuals, the expression levels of miRNA-199a-5p were significantly elevated in the gingivitis group compared to the healthy control group. Aditionally, the bleeding on probing (BOP %) values were significantly higher in group G compared to the healthy group. Conclusion: miRNA-199a-5p can be considered an important regulator with potential as both an early diagnostic biomarker and a therapeutic target for periodontal diseases. Although its role in autophagy and inflammation shows promise, further studies are needed to clarify its specific functions and clinical relevance.

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Cite This Article

Akdeniz, F. T., Nalbantoğlu, A. M., Barut, Z., Bulut, Ş., Avşar, O., Karadeniz, H. K., İsbir, T. (2025). Investigation of salivary miRNA-199a-5p levels in plaque-induced gingivitis. Anatolian Current Medical Journal, Volume: 7 Issue: 3. https://doi.org/10.38053/acmj.1676243

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