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Journals / Experimed / 2026 / Volume: 13 Issue: 2

Investigation of the Effect of Serum IL-1β Levels on Atherosclerosis: A Turkish Population-Based Study

Dilveen Dlawer Omer(Yeditepe University, Institute of Health Sciences, Department of Molecular Medicine)0000-0001-9213-445X
Fatma Tuba Akdeniz(Yeditepe University, Faculty of Medicine, Department of Medical Biology)0000-0002-6076-0509
Seda Güleç(Yeditepe University, Faculty of Medicine, Department of Medical Biology)0000-0002-8119-2862
Zerrin Barut(Antalya Bilim University, Faculty of Dentistry, Department of Basic Medical Sciences)0000-0002-6289-5562
Deryanaz Billur(Yeditepe University, Institute of Health Sciences, Department of Molecular Medicine)0000-0002-6079-8224
Ayça Türer Cabbar(Yeditepe University, Faculty of Medicine, Department of Cardiology)0000-0002-3521-2666
Turgay İsbir(Yeditepe University, Institute of Health Sciences, Department of Molecular Medicine)0000-0002-7350-6032
Journal
Experimed
Pages
—
Publication Date
2023-09-18
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Atherosclerosis, as a cardiovascular disease associated with chronic inflammatory conditions and involving a large number of risk factors, harbors a lot of unknowns.
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Key Findings & Data:It has not been fully elucidated in which stages and how interleukin-1 beta (IL-1β), which is associated with inflammations, plays a role in the chronic inflammatory process of the disease.
💡
Conclusion & Impact:Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Atherosclerosis · inflammation · IL-1β

Abstract

Objective: Atherosclerosis, as a cardiovascular disease associated with chronic inflammatory conditions and involving a large number of risk factors, harbors a lot of unknowns. Evidence has emerged that almost all stages of the disease are intertwined with inflammation. It has not been fully elucidated in which stages and how interleukin-1 beta (IL-1β), which is associated with inflammations, plays a role in the chronic inflammatory process of the disease. Also, the effect on atherosclerosis progression and biomarker candidacy of IL-1β in the Turkish population is unknown. The aim of this study was to investigate the serum IL-1β expression levels and whether it is associated with changes in risk factors that develop due to the disease in the Turkish population. Materials and Methods: ELISA method was used to analyze the serum IL-1β levels. Statistical data was obtained utilizing the SPSS v.23 software. Results: No linkage evidence was found between the serum IL-1β and atherosclerosis (p>0.05). However, the serum IL-1β levels were significantly associated with gender, smoking status, and diabetes history within the study population were significantly associated (p=0.050). According to the lipid profile result, the triglyceride value was found to be significantly decreased in atherosclerosis patients when compared to healthy individuals (p=0.012). Additionally, factors including, gender, smoking status, and history of diabetes were significantly associated with serum cholesterol level (p=0.015). Conclusion: Although no correlation was found between the serum IL-1β levels of the study groups, it was observed that the serum IL-1β expression alters in patients with atherosclerosis depending on age. In addition, low triglyceride levels may be a marker of disease in atherosclerosis patients. Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.

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Cite This Article

Omer, D. D., Akdeniz, F. T., Güleç, S., Barut, Z., Billur, D., Cabbar, A. T., İsbir, T. (2023). Investigation of the Effect of Serum IL-1β Levels on Atherosclerosis: A Turkish Population-Based Study. Experimed, Volume: 13 Issue: 2. https://doi.org/10.26650/experimed.1246321

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