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Journals / Experimed / 2026 / Volume: 13 Issue: 1

Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population

Gozde Ozcan(YEDITEPE UNIVERSITY, INSTITUTE OF HEALTH SCIENCES, DEPARTMENT OF MOLECULAR MEDICINE)0000-0001-6370-2980
Fatma Tuba Akdeniz(Yeditepe University, Faculty of Medicine, Department of Medical Biology)0000-0002-6076-0509
Seda Güleç(Yeditepe University, Faculty of Medicine, Department of Medical Biology)0000-0002-8119-2862
Zerrin Barut(Antalya Bilim University, Faculty of Dentistry, Department of Basic Medical Sciences)0000-0002-6289-5562
Deryanaz Billur(YEDITEPE UNIVERSITY, INSTITUTE OF HEALTH SCIENCES, DEPARTMENT OF MOLECULAR MEDICINE)0000-0002-6079-8224
Turgay İsbir(Yeditepe University, Faculty of Medicine, Department of Medical Biology)0000-0002-7350-6032
Cumhur Kaan Yaltırık(Umraniye Training and Research Hospital, Department of Neurosurgery)0000-0002-4312-5685
Journal
Experimed
Pages
—
Publication Date
2023-05-11
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: As a result of the preliminary findings, having the mutant T allele may increase risk by 3.36 times, whereas having the ancestral homozygote CC genotype lowers the risk for glioma in Turkish population.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Gliomas are devastating adult brain tumors of unknown etiology, occupying 8 out of 10 primary brain tumors.
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Key Findings & Data:Epidermal growth factor receptor (EGFR) as a tyrosine kinase family member is encoded by the EGFR gene located in chromosome 7p12-13.
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Conclusion & Impact:Conclusion: As a result of the preliminary findings, having the mutant T allele may increase risk by 3.36 times, whereas having the ancestral homozygote CC genotype lowers the risk for glioma in Turkish population.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Glioma · EGFR Gene · Variation

Abstract

Objective: Gliomas are devastating adult brain tumors of unknown etiology, occupying 8 out of 10 primary brain tumors. Epidermal growth factor receptor (EGFR) as a tyrosine kinase family member is encoded by the EGFR gene located in chromosome 7p12-13. Various studies have identified numerous SNPs, including those in the EGFR gene, as linked to gliomas. The objective of the investigation was to determine whether the genotype and allele frequencies of the EGFR may have a role in glioma susceptibility. Materials and Methods: To examine the association of EGFR SNP rs1468727 with glioma susceptibility in a case-control study from Türkiye (34 cases, 36 controls), genotyping and statistical analyses were performed by using real-time-polymerase chain reaction (RT-PCR) and SPSS version 25.0, respectively. Results: A significant relationship was found between the study groups EGFR SNP rs1468727 genotypes (p = 0.028). The CC genotype frequency was significantly greater in the control group compared to the glioma group (p=0.005). When compared with the control group, the frequency of mutant type T allele carriers was significantly higher in glioma patients (p=0.012). Conclusion: As a result of the preliminary findings, having the mutant T allele may increase risk by 3.36 times, whereas having the ancestral homozygote CC genotype lowers the risk for glioma in Turkish population.

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Cite This Article

Ozcan, G., Akdeniz, F. T., Güleç, S., Barut, Z., Billur, D., İsbir, T., Yaltırık, C. K. (2023). Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population. Experimed, Volume: 13 Issue: 1. https://doi.org/10.26650/experimed.1232534

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