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Journals / Journal of advances in vetbio science and techniques / 2026 / Volume: 7 Issue: 1

Investigation of respiratory syncytial virus (RSV) and parainfluenza-3 (PI-3) virus by histopathological and immunohistochemical methods in sheep and goat

Funda Terzi(KASTAMONU ÜNİVERSİTESİ)0000-0002-6184-5408
Ayşe Gül Dal(Samsun Veteriner Kontrol Enstitüsü)0000-0002-0607-2182
Serdar Odacı(Samsun Veteriner Kontrol Enstitüsü)0000-0002-3325-9196
Yavuz Ulusoy(Etlik Veteriner Kontrol Merkez Araştırma Enstitüsü)
Bahadır Kılınç(Etlik Central Veterinary Control and Research Institute, Pathology Department, 06020,Ankara, Turkey)0000-0003-3426-2116
Pages
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Publication Date
2022-04-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Koyun ve keçi akciğer dokusunda, RSV ve PI-3 virusun neden olduğu sitokin yanıt mekanizmasının moleküler yöntemlerle araştırılması gerektiği düşünülmektedir.

📌 3 Key Takeaways

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Objective & Hypothesis:Koyun ve keçilerde Respiratuar Sinsitiyal Virüsü (RSV) ve Parainfluenza tip 3 (PI3) virüsü ciddi solunum sistemi enfeksiyonlarına neden olmaktadır.
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Key Findings & Data:Çalışmada, koyun ve keçi RSV ve PI-3 virüsünün akciğer dokusundaki yerleşimi ve dağılımının histopatolojik ve immünohistokimyasal yöntemlerle araştırılması amaçlandı.
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Conclusion & Impact:Koyun ve keçi akciğer dokusunda, RSV ve PI-3 virusun neden olduğu sitokin yanıt mekanizmasının moleküler yöntemlerle araştırılması gerektiği düşünülmektedir.
🔬Design:Research Article
📍Scope:2016-2019 · 30 adet
⚙️Variables:RSV · PI-3 · Immunohistochemistry

Abstract

Koyun ve keçilerde Respiratuar Sinsitiyal Virüsü (RSV) ve Parainfluenza tip 3 (PI3) virüsü ciddi solunum sistemi enfeksiyonlarına neden olmaktadır. Çalışmada, koyun ve keçi RSV ve PI-3 virüsünün akciğer dokusundaki yerleşimi ve dağılımının histopatolojik ve immünohistokimyasal yöntemlerle araştırılması amaçlandı. Çalışma materyalini, 2016-2019 yılları arasında, Samsun ve çevre yörelerinden Samsun Kontrol ve Veteriner Araştırma Enstitüsüne gelen 30 adet koyun ve 24 adet keçi akciğer parafin blok dokusu oluşturdu. Akciğer parafin blok dokularının histopatolojik incelemesinde, bronş ve bronşiyol epitelinde dejenerasyon ve dökülme, interalveolar septumda kalınlaşma, epitelizasyon ve alveolar makrofajlarda artış yaygın olarak görülürken, lenfoid doku da hiperplazi, hiyalin membran oluşumu ve sinsityal hücrelere daha az oranda rastlandı. Ayrıca hiçbir olguda bronşiolitis obliteransa rastlanmadı. İmmünhistokimyasal olarak, koyunların %50'sinde ve keçilerin %54'ünde RSV antijeni, koyunların %40'ında ve keçilerin %50'sinde PI-3 antijeni tespit edildi. Koyun ve keçi akciğer parafin kesitlerinde RSV ve PI-3 antijeni, bronş ve bronşiol epitel hücreleri ile lümende dökülmüş hücrelerinde ve interalveolar septum hücrelerinde istatistiksel olarak benzerdi (P>0.05). Alveolar makrofajlarda keçilerde PI-3 antijeni, koyunlara göre istatistiksel olarak daha yoğun boyandı(P<0.05). Koyun ve keçi akciğer dokusunda RSV ve PI-3 antijeninin replikasyon alanları benzer olduğu kanısına varıldı. Koyun ve keçi akciğer dokusunda, RSV ve PI-3 virusun neden olduğu sitokin yanıt mekanizmasının moleküler yöntemlerle araştırılması gerektiği düşünülmektedir.

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Cite This Article

Terzi, F., Dal, A. G., Odacı, S., Ulusoy, Y., Kılınç, B. (2022). Investigation of respiratory syncytial virus (RSV) and parainfluenza-3 (PI-3) virus by histopathological and immunohistochemical methods in sheep and goat. Journal of advances in vetbio science and techniques, Volume: 7 Issue: 1. https://doi.org/10.31797/vetbio.976306

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