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Journals / Journal of advances in vetbio science and techniques / 2026 / Issue: 3

Gastroprotective effects of Maclura pomifera aqueous extract against indomethacin-induced gastric ulcers: role of antioxidant pathways

Recai Aci(Aydın Adnan Menderes Üniversitesi Söke Sağlık Hizmetleri Meslek Yüksekokulu)0000-0002-1517-3356
Murat Koç(YILDIRIM BEYAZIT ÜNİVERSİTESİ)0000-0002-0829-4571
Mesut Bünyami Halıcı(ATATURK UNIVERSITY)0000-0002-7473-2955
Utku Duran(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ)0000-0002-0002-8893
Pages
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Publication Date
2026-10-20
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings indicate that MPSE protects gastric tissue against IND-induced injury, at least in part, by modulating antioxidant defenses and limiting oxidative damage.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study investigated the in vivo gastroprotective effects of an aqueous Maclura pomifera fruit extract (MPSE) in an indomethacin-induced gastric ulcer model and examined the involvement of antioxidant defense mechanisms.
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Key Findings & Data:Thirty male rats were randomly assigned to five groups (n=6 per group): healthy control, indomethacin ulcer control, ranitidine reference, MPSE 250 mg/kg, and MPSE 500 mg/kg.
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Conclusion & Impact:These findings indicate that MPSE protects gastric tissue against IND-induced injury, at least in part, by modulating antioxidant defenses and limiting oxidative damage.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Antioxidant activity · Anti-ulcerogenic activity · Indomethacin

Abstract

This study investigated the in vivo gastroprotective effects of an aqueous Maclura pomifera fruit extract (MPSE) in an indomethacin-induced gastric ulcer model and examined the involvement of antioxidant defense mechanisms. Thirty male rats were randomly assigned to five groups (n=6 per group): healthy control, indomethacin ulcer control, ranitidine reference, MPSE 250 mg/kg, and MPSE 500 mg/kg. After fasting, the healthy control group received tap water only; the ulcer control group received indomethacin (IND; 25 mg/kg); the reference group received ranitidine (RAN; 50 mg/kg) plus IND; and the MPSE groups received MPSE (250 or 500 mg/kg) plus IND. MPSE, ranitidine, tap water, and IND were administered orally according to group allocation, with IND given 5 min after pretreatment. Six hours after IND administration, gastric ulcer area and the tissue levels or activities of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and lipid peroxidation (LPO) were evaluated. MPSE reduced ulcer formation in a dose-dependent manner. IND decreased SOD activity and GSH levels and increased CAT activity and LPO levels. MPSE, particularly at 500 mg/kg, restored SOD and GSH, normalized CAT activity, and reduced LPO. These findings indicate that MPSE protects gastric tissue against IND-induced injury, at least in part, by modulating antioxidant defenses and limiting oxidative damage.

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Cite This Article

Aci, R., Koç, M., Halıcı, M. B., Duran, U. (2026). Gastroprotective effects of Maclura pomifera aqueous extract against indomethacin-induced gastric ulcers: role of antioxidant pathways. Journal of advances in vetbio science and techniques, Issue: 3. https://doi.org/10.31797/vetbio.1964859

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