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Journals / Journal of advances in vetbio science and techniques / 2026 / Volume: 9 Issue: 1

The effect of letrozole on liver function and some biochemical parameters in rats

Turgut Dolanbay(NIGDE UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-4092-1192
Mustafa Makav(KAFKAS UNIVERSITY, FACULTY OF VETERINARY MEDICINE)0000-0003-1879-8180
Abdussamed Vural(NIGDE UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-4506-916X
Mustafa Oguz Cumaoglu(NIGDE UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-4245-1101
Ömer Yüceer(NIGDE UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-5242-0571
Lale Başer(KAFKAS UNIVERSITY, FACULTY OF VETERINARY MEDICINE)0000-0003-0659-6346
Hatice Tetik Metin(BİTLİS EREN ÜNİVERSİTESİ, SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU)0000-0002-5659-7147
Pages
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Publication Date
2024-04-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, it was determined that LTZ has toxic and detrimental effects on the liver.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Letrozole (LTZ), is an aromatase inhibitor, that has been widely used in a variety of diseases such as polycystic ovary syndrome, endometriosis, and breast cancer.
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Key Findings & Data:For this purpose, 16 Wistar albino female rats were divided into two groups (n=8): Control and LTZ respectively.
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Conclusion & Impact:In conclusion, it was determined that LTZ has toxic and detrimental effects on the liver.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Letrazole · hepatotoxicity · liver function tests

Abstract

Letrozole (LTZ), is an aromatase inhibitor, that has been widely used in a variety of diseases such as polycystic ovary syndrome, endometriosis, and breast cancer. LTZ is received via the oral route and metabolized in the liver. Therefore, LTZ may have toxic effects like other drugs metabolized in the liver. Based on this, our study aimed to investigate the effect of LTZ on liver function and biochemical parameters. For this purpose, 16 Wistar albino female rats were divided into two groups (n=8): Control and LTZ respectively. The rats in the letrozole group were administered with 2 mL/kg LTZ by oral gavage once a day for 21 days. The Control group received the vehicle once a day for 21 days. Blood samples were collected on the 22nd day of the experiment. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), albumin (ALB), alkaline phosphatase (ALP), direct bilirubin and total bilirubin were measured. Biochemical analysis indicated that ALT, AST, LDH, ALP, and total bilirubin levels were significantly higher in the LTZ administrated group compared to the Control. ALB levels decreased in the LTZ group. In conclusion, it was determined that LTZ has toxic and detrimental effects on the liver. We suggested that long-term LTZ administrated patients should be under control against liver damage and may have liver supporting adjuvant therapies for robust liver functions.

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Cite This Article

Dolanbay, T., Makav, M., Vural, A., Cumaoglu, M. O., Yüceer, Ö., Başer, L., Metin, H. T. (2024). The effect of letrozole on liver function and some biochemical parameters in rats. Journal of advances in vetbio science and techniques, Volume: 9 Issue: 1. https://doi.org/10.31797/vetbio.1451147

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