Journals / Journal of advances in vetbio science and techniques / 2024 / Volume: 9 Issue: 3

Effects of increasing doses of enrofloxacin on biochemical parameters in ducks

Duygu Durna Çorum(Hatay Mustafa Kemal University)0000-0003-1567-991X
Devran Coşkun(SIIRT UNIVERSITY, FACULTY OF VETERINARY MEDICINE, VETERINARY MEDICINE PR.)0000-0003-1151-1861
Feray Altan(DOKUZ EYLÜL ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0002-9017-763X
Zafer Bulut(DOKUZ EYLÜL ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0003-1794-1651
Orhan Çorum(Hatay Mustafa Kemal Üniversitesi Veteriner Fakültesi)0000-0003-3168-2510
Pages
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Publication Date
2024-12-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, it was determined that oral administration of enrofloxacin to ducks at doses of 10, 50, and 100 mg/kg caused temporary changes in biochemical parameters.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This research aims to determine the effect of oral single-dose administration of 10, 50, and 100 mg/kg of enrofloxacin on ducks on biochemical parameters.
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Key Findings & Data:Ducks were divided into 3 equal groups to receive 10, 50, and 100 mg/kg doses.
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Conclusion & Impact:In conclusion, it was determined that oral administration of enrofloxacin to ducks at doses of 10, 50, and 100 mg/kg caused temporary changes in biochemical parameters.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Ascending dose · biochemical · duck

Abstract

This research aims to determine the effect of oral single-dose administration of 10, 50, and 100 mg/kg of enrofloxacin on ducks on biochemical parameters. The research was carried out on eighteen ducks. Ducks were divided into 3 equal groups to receive 10, 50, and 100 mg/kg doses. Blood samples were taken at 0, 6, 12, 24 and 48 hours. No clinical side effects were observed in ducks after enrofloxacin administration. When dose groups were compared, significant differences were observed in aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), albumin (ALB), cholesterol (CHOL), total protein (TP) and creatinine (CRE) values (p<0.05). However, these differences returned to normal at the 48 hour. When the dose groups were evaluated within themselves, ALT, GGT, CHOL, triglyceride, and urea values did not differ (p>0.05). However, there were significant differences in AST, ALP, ALB, and CRE values at 10 mg/kg, AST at 50 mg/kg, and TP at 100 mg/kg (p<0.05). In conclusion, it was determined that oral administration of enrofloxacin to ducks at doses of 10, 50, and 100 mg/kg caused temporary changes in biochemical parameters. In this study, enrofloxacin was administered as a single dose. However, considering the repeated use of enrofloxacin in case of bacterial infection, attention should be paid to possible adverse effects that may occur in ducks.

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Cite This Article

Çorum, D. D., Coşkun, D., Altan, F., Bulut, Z., Çorum, O. (2024). Effects of increasing doses of enrofloxacin on biochemical parameters in ducks. Journal of advances in vetbio science and techniques, Volume: 9 Issue: 3. https://doi.org/10.31797/vetbio.1503966

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References (29)

  1. Adzitey, F., & Adzitey, S. P. (2011). Duck production: has a potential to reduce poverty among rural households in asian communities – a review. Journal of World’s Poultry Research, 1(1), 7–10.
  2. Aggad, H., Ammar, Y. A., Hammoudi, A., & Kihal, M. (2010). Antimicrobial resistance of Escherichia coli isolated from chickens with colibacillosis. Global Veterinaria, 4(3), 303–306. https://doi.org/10.1637/10325-081512-Case.1
  3. Amen, O., Hussein, A., Ibrahim, R., & Sayed, A. (2019). Detection of antibiotics resistance genes in Staphylococcus aureus isolated from poultry farms. Assiut Veterinary Medical Journal, 65(163), 1–9. https://doi.org/10.21608/AVMJ.2019.166588
  4. Bonassa, K. P., Miragliotta, M. Y., Simas, R. C., Eberlin, M. N., Anadón, A., Moreno, R. A., & Reyes, F. G. (2021). Pharmacokinetics, pharmacodynamic efficacy prediction indexes, and Monte Carlo simulations of enrofloxacin hydrochloride against bacterial strains That induce common clinical diseases in broiler chickens. Frontiers in Veterinary Science, 7, 606872. https://doi.org/10.3389/fvets.2020.606872
  5. Cerda, R. O., Giacoboni, G. I., Xavier, J. A., Sansalone, P. L., & Landoni, M. F. (2002). In vitro antibiotic susceptibility of field isolates of Mycoplasma synoviae in Argentina. Avian Diseases, 46(1), 215–218. https://doi.org/10.1637/0005-2086(2002)046[0215:IVASOF]2.0.CO;2
  6. Corum, O., Altan, F., Yildiz, R., Ider, M., Ok, M., & Uney, K. (2019). Pharmacokinetics of enrofloxacin and danofloxacin in premature calves. Journal of Veterinary Pharmacology and Therapeutics, 42(6), 624–631. https://doi.org/10.1111/jvp.12787
  7. Corum, O., Coskun, D., Karahan, M., & Durna Corum, D. (2024). Effect of different doses of tolfenamic acid administration to ducks on biochemical parameters. Harran University Journal of The Faculty of Veterinary Medicine, 13(1), 8–13. https://doi.org/10.31196/huvfd.1350424
  8. Corum, O., Er, A., Dik, B., Eser Faki H., Bahcivan, E., & Yazar, E. (2015). Determination of the safety of tulathromycin in sheep. Eurasian Journal of Veterinary Sciences, 31(3), 152–157.
  9. Coskun, D., Corum, O., & Yazar, E. (2020). Effect of supportive therapy on the pharmacokinetics of intravenous marbofloxacin in endotoxemic sheep. Journal of Veterinary Pharmacology and Therapeutics, 43(3), 288–296. https://doi.org/10.1111/jvp.12849
  10. Coskun, D., Corum, O., Corum, D. D., & Uney, K. (2023). Pharmacokinetics and bioavailability of meloxicam in Pekin ducks following intravenous, intramuscular and oral administration. Veterinary Anaesthesia and Analgesia, 50(6), 477–484. https://doi.org/10.1016/j.vaa.2023.07.007
  11. Coskun, D., Parlak, K., Dik, B., Faki, H. E., Bahcivan, E., Yazar, E., & Er, A. (2018). Effect of enrofloxacin on the joint fluid/blood oxidative status and organ damage markers. Annual Research & Review in Biology, 25(3), 1–7. https://doi.org/10.9734/ARRB/2018/40537
  12. Ellakany, H. F., Abu El-Azm, I. M., Bekhit, A. A., & Shehawy, M. M. (2008). Studies on the effects of enrofloxacin overdose on different health parameters in broiler chickens. Journal of Veterinary Medical Research, 18(1), 176–186. https://doi.org/10.21608/JVMR.2008.77869
  13. EMA. (2001). Questions and answers on use of enrofloxacin-containing veterinary medicines administered via drinking water to chickens and turkeys. https://www.ema.europa.eu/en/documents/referral/enrofloxacin-article-35-referral-veterinary-medicines-containing-enrofloxacin-be-administered-drinking-water-chickens-and-or-turkeys-article-35-referral-annexes_en.pdf.
  14. Flammer, K., Aucoin, D. P., & Whitt, D. A. (1991). Intramuscular and oral disposition of enrofloxacin in African grey parrots following single and multiple doses. Journal of Veterinary Pharmacology and Therapeutics, 14(4), 359–366. https://doi.org/10.1111/j.1365-2885.1991.tb00849.x
  15. Ibrahim, I. G., Atmaca, N., Kanici, A., & Yarsan, E. (2011). Evaluation of effects of enrofloxacin on some haematological parameters in broilers. Atatürk University Journal of Veterinary Sciences, 6(2), 97–102.
  16. Kang, J., Hossain, M. A., Park, H. C., Kim, Y., Lee, K. J., & Park, S. W. (2019). Pharmacokinetic and pharmacodynamic integration of enrofloxacin against Salmonella Enteritidis after administering to broiler chicken by per-oral and intravenous routes. Journal of Veterinary Science, 20(2). https://doi.org/10.4142/jvs.2019.20.e15
  17. Khan, A. M., Rampal, S., & Sood, N. K. (2017). Effect of repeated oral administration of levofloxacin, enrofloxacin, and meloxicam on antioxidant parameters and lipid peroxidation in rabbits. Human & Experimental Toxicology, 36(1), 42–50. https://doi.org/10.1177/0960327116637111
  18. Khazaeil, K., Mazaheri, Y., Hashemitabar, M., Najafzadeh, H., Morovvati, H., & Ghadrdan, A. R. (2012). Enrofloxacin effect on histomorphologic and histomorphometric structure of lamb articular cartilage. Global Veterinaria, 9, 447–453. https://doi.org/10.5829/idosi.gv.2012.9.4.2035
  19. Li, J., Hao, H., Cheng, G., Liu, C., Ahmed, S., Shabbir, M. A., Hussain, H. I., Dai, M., & Yuan, Z. (2017a). Microbial shifts in the intestinal microbiota of Salmonella infected chickens in response to enrofloxacin. Frontiers in Microbiology, 8, 1711. https://doi.org/10.3389/fmicb.2017.01711
  20. Li, J., Hao, H., Cheng, G., Wang, X., Ahmed, S., Shabbir, M. A. B., Liu, Z., Dai, M., & Yuan, Z. (2017b). The effects of different enrofloxacin dosages on clinical efficacy and resistance development in chickens experimentally infected with Salmonella Typhimurium. Scientific Reports, 7(1), 11676. https://doi.org/10.1038/s41598-017-12294-7
  21. Maślanka, T., Jaroszewski, J. J., Mikołajczyk, A., & Rotkiewicz, T. (2009). Effect of increasing doses of enrofloxacin on chicken articular cartilage. Polish Journal of Veterinary Sciences, 12(01), 21–33.
  22. Mishra, P., Gautam, V., Sharma, R. K., & Tiwari, A. (2021). Alterations in biochemical markers of liver and kidney function and oxidative stress indices on sub-acute exposure of enrofloxacin in albino rats. Indian Journal of Animal Research, 1, 7. https://doi.org/10.18805/IJAR.B-4453.
  23. Patil, S. S., Shinduja, R., Suresh, K. P., Phukan, S., Kumar, S., Sengupta, P. P., & Prasad, K. S. (2021). A systematic review and meta-analysis on the prevalence of infectious diseases of Duck: A world perspective. Saudi Journal of Biological Sciences, 28(9), 5131–5144. https://doi.org/10.1016/j.sjbs.2021.05.034
  24. Riviere, J. E., & Papich, M. G. (2018). Veterinary Pharmacology and Therapeutics. John Wiley & Sons. Shoorijeh, S. J., Tamadon, A., Vahedi, M., & Behzadi, M. A. (2012). Hematological and biochemical alterations due to over dosage of enrofloxacin in cats. Pakistan Veterinary Journal, 32(1), 73–76.
  25. Srinivasu, M., Singh, S. P., Ahmad, A. H., & Pathak, A. (2022). Effect of enrofloxacin and ciprofloxacin on oxidative stress in rats. Journal of Veterinary Pharmacology and Toxicology, 21(1), 80–82.
  26. Temmerman, R., Pelligand, L., Schelstraete, W., Antonissen, G., Garmyn, A., & Devreese, M. (2021). Enrofloxacin dose optimization for the treatment of colibacillosis in broiler chickens using a drinking behaviour pharmacokinetic model. Antibiotics, 10(5), 604. https://doi.org/10.3390/antibiotics10050604
  27. Uney, K., Terzi, E., Durna Corum, D., Ozdemir, R. C., Bilen, S., & Corum, O. (2021). Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of enrofloxacin following single oral administration of different doses in brown trout (Salmo trutta). Animals, 11(11), 3086. https://doi.org/10.3390/ani11113086
  28. Vinay, P. T., Ravindra, B. G., Vijaykumar, M., Sunilchandra, U., & Kulkarni, S. (2017). Effect of enrofloxacin on hematological and biochemical parameters in dogs. The Pharma Innovation, 6(2, Part C), 167.
  29. Westropp, J. L., Sykes, J. E., Irom, S., Daniels, J. B., Smith, A., Keil, D., Settje, T., Wang, Y., & Chew, D. J. (2012). Evaluation of the efficacy and safety of high dose short duration enrofloxacin treatment regimen for uncomplicated urinary tract infections in dogs. Journal of Veterinary Internal Medicine, 26(3), 506–512. https://doi.org/10.1111/j.1939-1676.2012.00914.x