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Journals / Journal of advances in vetbio science and techniques / 2025 / Volume: 10 Issue: 3

Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity

Cemre Aydeğer(ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, FİZYOLOJİ ANABİLİM DALI)
Mehmet Akif Ovalı(ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, FİZYOLOJİ ANABİLİM DALI)0000-0002-3672-871X
Mustafa Oguz Cumaoglu(NIGDE OMER HALISDEMIR UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF EMERGENCY MEDICINE)0000-0003-4245-1101
Hilmi Nuhoğlu(KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, HASTALIKLAR VE KLİNİK BİLİMLERİ BÖLÜMÜ, PATOLOJİ ANABİLİM DALI)0000-0003-2530-2542
Tahir Gezer(KAFKAS ÜNİVERSİTESİ)0000-0001-7838-2553
Mustafa Makav(KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, VETERİNER HEKİMLİĞİ TEMEL BİLİMLERİ BÖLÜMÜ, VETERİNERLİK FİZYOLOJİSİ ANABİLİM DALI)0000-0003-1879-8180
Hüseyin Avni Eroğlu(ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, FİZYOLOJİ ANABİLİM DALI)0000-0002-1040-3255
Pages
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Publication Date
2025-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results showed that the Dox group experienced significant glomerular atrophy.

📌 3 Key Takeaways

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Objective & Hypothesis:Doxorubicin (DOX) is a widely used antineoplastic agent in cancer treatment; however, it has several drawbacks that can cause harmful effects on various organs, especially the kidneys.
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Key Findings & Data:A total of 14 female Wistar Albino rats were divided into two equal groups: Control and Dox.
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Conclusion & Impact:Our results showed that the Dox group experienced significant glomerular atrophy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Doxorubicin · adverse effect · drug toxicity

Abstract

Doxorubicin (DOX) is a widely used antineoplastic agent in cancer treatment; however, it has several drawbacks that can cause harmful effects on various organs, especially the kidneys. Nevertheless, it does not fully reveal the extent of DOX-induced tissue damage. Therefore, it is crucial to clarify the risks associated with DOX-mediated tissue injury. A total of 14 female Wistar Albino rats were divided into two equal groups: Control and Dox. The Dox group received a single dose of 20 mg/kg DOX. Kidney, liver, and blood samples were collected for further analysis. Hematoxylin-Eosin staining and biochemical tests were conducted to assess DOX-induced tissue damage. Our results showed that the Dox group experienced significant glomerular atrophy. Parameters such as RBC, HGB, HCT, and MCHC were also significantly higher compared to the Control group. No significant differences were observed in liver tissues between the groups. Inflammatory markers were also evaluated. NLR and SII scores showed statistically significant differences between the groups. Administration of DOX caused alterations in erythrocyte and leukocyte parameters, with notable changes in renal tissue characterized by glomerular atrophy.

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Cite This Article

Aydeğer, C., Ovalı, M. A., Cumaoglu, M. O., Nuhoğlu, H., Gezer, T., Makav, M., Eroğlu, H. A. (2025). Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity. Journal of advances in vetbio science and techniques, Volume: 10 Issue: 3. https://doi.org/10.31797/vetbio.1786702

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