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Journals / Journal of advances in vetbio science and techniques / 2025 / Volume: 10 Issue: 3

Oxidative stress in Neospora-positive dairy cows with embryonic losses

Gaye Bulut(Aksaray Üniversitesi)0000-0003-4500-1958
Caner Ozturk(AKSARAY ÜNİVERSİTESİ)0000-0003-0566-0684
Neşe Hayat Aksoy(AKSARAY ÜNİVERSİTESİ)0000-0001-9039-555X
Pages
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Publication Date
2025-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Systemic biomarkers may underestimate this effect; therefore, further tissue-level studies are needed to clarify the pathogen’s contribution to embryonic loss.

📌 3 Key Takeaways

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Objective & Hypothesis:This study was conducted to evaluate the oxidative status of Holstein-Friesian cows that experienced embryonic loss and were either seropositive or seronegative for Neospora caninum.
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Key Findings & Data:Mean total antioxidant status (TAS) was similar between groups, ranging from 952.6 ± 499.0 to 1110.3 ± 260.0 µmol/L in Neospora- positive (NP) cows and from 1233.1 ± 372.4 to 1739.7 ± 599.1 µmol/L in Neospora- negative (NN) cows (p > 0.05).
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Conclusion & Impact:Systemic biomarkers may underestimate this effect; therefore, further tissue-level studies are needed to clarify the pathogen’s contribution to embryonic loss.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Dairy cattle · Infertility · Neospora caninum

Abstract

This study was conducted to evaluate the oxidative status of Holstein-Friesian cows that experienced embryonic loss and were either seropositive or seronegative for Neospora caninum. Mean total antioxidant status (TAS) was similar between groups, ranging from 952.6 ± 499.0 to 1110.3 ± 260.0 µmol/L in Neospora- positive (NP) cows and from 1233.1 ± 372.4 to 1739.7 ± 599.1 µmol/L in Neospora- negative (NN) cows (p > 0.05). In contrast, total oxidant status (TOS) and oxidative stress index (OSI) increased significantly with advancing lactation in NP cows. TOS rose from 52.4 ± 10.3 µmol/L in the 2nd lactation to 114.8 ± 51.0 and 143.3 ± 29.5 µmol/L in the 4th and 5th lactations (p <0.05). Similarly, OSI increased from 8.09 ± 7.56 in the 2nd lactation to 12.91 ± 3.83 and 13.78 ± 5.43 in the 4th and 5th lactations (p <0.05). NN cows maintained lower oxidative stress, with TOS between 25.3 ± 5.4 and 51.4 ± 14.1 µmol/L and OSI between 1.57 ± 0.48 and 4.39 ± 1.62. The lowest OSI was observed in NN cows in the 2nd lactation (1.57 ± 0.48; p <0.05). These findings suggest that N. caninum infection exacerbates oxidative imbalance, particularly in later lactations, increasing susceptibility to reproductive failure. Systemic biomarkers may underestimate this effect; therefore, further tissue-level studies are needed to clarify the pathogen’s contribution to embryonic loss.

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Cite This Article

Bulut, G., Ozturk, C., Aksoy, N. H. (2025). Oxidative stress in Neospora-positive dairy cows with embryonic losses. Journal of advances in vetbio science and techniques, Volume: 10 Issue: 3. https://doi.org/10.31797/vetbio.1780081

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