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Journals / Journal of advances in vetbio science and techniques / 2026 / Issue: 1

Evaluation of clinical, histopathological and some biochemical parameters of butarphanol-propofol combination in Japanese quails

Ömer Kırgız(HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ, VETERİNERLİK CERRAHİSİ ANABİLİM DALI)0000-0002-0222-1363
Gökhan Akçakavak(AKSARAY ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0001-5949-4752
Pages
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Publication Date
2026-01-11
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Histopathological findings revealed hepatocyte degeneration, congestion, and inflammatory infiltration in the liver, and renal tubular epithelial degeneration and desquamation in the kidneys.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The selection of safe anesthesia in avian species is of great importance.
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Key Findings & Data:The B+P group was given a 3 mg/kg intramuscular injection of butorphanol followed, after 10 minutes, by 10 mg/kg intravenous propofol; the control group was given nothing and healthy liver and kidney tissues were taken for comparison.
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Conclusion & Impact:Histopathological findings revealed hepatocyte degeneration, congestion, and inflammatory infiltration in the liver, and renal tubular epithelial degeneration and desquamation in the kidneys.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Japanese Quails · Butarphanol · Propofol

Abstract

The selection of safe anesthesia in avian species is of great importance. In this study, the clinical, biochemical and histopathological effects of butorphanol-propofol (B+P) combination in Japanese quails (Coturnix coturnix japonica) were evaluated. Sixteen adult Japanese quails were used. One group was the control; the other was B+P. The B+P group was given a 3 mg/kg intramuscular injection of butorphanol followed, after 10 minutes, by 10 mg/kg intravenous propofol; the control group was given nothing and healthy liver and kidney tissues were taken for comparison. Clinical parameter values, including heart rate (HR), respiratory rate (RR), and cloacal temperature (CT), were recorded before and after anesthesia. Blood samples were taken pre- and post-anesthetic for biochemical analysis and histopathological examination of liver and kidney tissues carried out. Heart rate and respiratory rate decreased significantly during the first 20 minutes. CT gradually decreased but remained within a safe range. Reflex responses varied, as anesthesia was effective for approximately 20 minutes and wore off after approximately 30 to 45 minutes. Biochemical analyses revealed significant increases in Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Total Protein (TP), and Creatinine (CRE) levels. Histopathological findings revealed hepatocyte degeneration, congestion, and inflammatory infiltration in the liver, and renal tubular epithelial degeneration and desquamation in the kidneys. In conclusion, the butorphanol-propofol combination provided effective short-term anesthesia and analgesia in Japanese quails. However, due to effects on body temperature, cardiopulmonary parameters, and potential hepatic and renal changes, dosage and duration should be carefully considered in clinical applications.

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Cite This Article

Kırgız, Ö., Akçakavak, G. (2026). Evaluation of clinical, histopathological and some biochemical parameters of butarphanol-propofol combination in Japanese quails. Journal of advances in vetbio science and techniques, Issue: 1. https://doi.org/10.31797/vetbio.1770678

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References (23)

  1. Akcakavak, G., Karatas, O., Celik, Z., Tural, A., Dagar, O., Abduljabbar, A., Kılınc, B., & Tuzcu, M. (2024). Taxifolin attenuates cisplatin-induced kidney damage in rats via suppressing p53 and iNOS. Etlik Veteriner Mikrobiyoloji Dergisi, 35(1), 1-7. https://doi.org/10.35864/evmd.1458328
  2. Al-Sobayil, F. A., Ahmed, A. F., Al-Wabel, N. A., Al-Thonayian, A. A., Al-Rogibah, F. A., Al-Fuaim, A. H., & Al-Muzaini, A. M. (2009). The use of xylazine, ketamine, and isoflurane for induction and maintenance of anesthesia in ostriches (Struthio camelus). Journal of Avian Medicine and Surgery, 23(2), 101-107. https://doi.org/10.1647/2008-034.1
  3. Altuğ M. E., & Kırgız, Ö. (2022). Kanatlı Hekimliği. In E. Yarsan (Eds.), Kanatlılarda analjezi ve anestezi (pp. 1101-1164). Güneş kitapevi Press, Ankara.
  4. Atalan, G., Uzun, M., Demirkan, I., Yildiz, S., & Cenesiz, M. (2002). Effect of medetomidine‐butorphanol‐ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal temperature of domestic pigeons. Journal of Veterinary Medicine Series A, 49(6), 281-285. https://doi.org/10.1046/j.1439-0442.2002.00451.x
  5. Chan, M. T., Cheng, B. C., Lee, T. M., & Gin, T. (2013). BIS-guided anesthesia decreases postoperative delirium and cognitive decline. Journal of Neurosurgical Anesthesiology, 25(1), 33-42. https://doi.org/10.1097/ANA.0b013e3182712fba
  6. Fitzgerald, G., & Cooper, J. E. (1990). Preliminary studies on the use of propofol in the domestic pigeon (Columba livia). Research in Veterinary Sciences, 49(3), 334–338. https://doi.org/10.1016/0034-5288(90)90069-G
  7. Hohtola, E., Hissa, R., Pyörnilä, A., Rintamäki, H., & Saarela, S. (1991). Nocturnal hypothermia in fasting Japanese quail: the effect of ambient temperature. Physiology & behavior, 49(3), 563-567. https://doi.org/10.1016/0031-9384(91)90281-R
  8. Horowitz, I. H., Vaadia, G., Landau, S., Yanco, E., & Lublin, A. (2014). Butorphanol-midazolam combination injection for sedation of great white pelicans (Pelecanus onocrotalus). Israel Journal of Veterinary Medicine, 69(1), 35-39.
  9. Kamiloğlu, A., Yayla, S., Kamiloğlu, N. N., Özaydin, I., & Kurt, B. (2014). Clinical evaluation of intramuscular and intraosseous xylazine-ketamine anesthesia in quails (Coturnix coturnix japonica). Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 11(3), 169-174.
  10. Kembro, J. M., Guzman, D. A., Perillo, M. A., & Marin, R. H. (2012). Temporal pattern of locomotor activity recuperation after administration of propofol in Japanese quail (Coturnix coturnix japonica). Research in Veterinary Science, 93(1), 156-162. https://doi.org/10.1016/j.rvsc.2011.06.011
  11. Kubiak, M., Roach, L., & Eatwell, K. (2016). The influence of a combined butorphanol and midazolam premedication on anesthesia in psittacid species. Journal of Avian Medicine and Surgery, 30(4), 317-323. https://doi.org/10.1647/2013-072
  12. Langan, J. N., Ramsay, E. C., James, T. B., & Juergen, S. (2000) Cardiopulmonary and sedative effects of intramuscular medetomidine-ketamine and intravenous propofol in ostriches (Struthio camelus). Journal of the Academy of Marketing Science, 14(1), 2-7.
  13. Lon, V. K., Vanessa, L. O., & Trinka, W. A.(2023). Pharmacology of analgesics. In M. Dyson, P. Jirkof, J. Lofgren, E. Nunamaker & D. Pang. (Eds.), Anesthesia and analgesia in laboratory animals (pp. 139-185). Academic Press.
  14. Lumeij, J. T., & Deenik, J. W. (2003). Medetomidine-ketamine and diazepam-ketamine anesthesia in racing pigeons (Columba livia domestica)—Acomparative study. Journal of Avian Medicine and Surgery, 17(4), 191-196. https://doi.org/10.1647/2001-048
  15. Mousavi, A., Abedi, G., Jahandide, A., & Hesaraki, S. (2019). Histopathological and serum enzyme changes of propofol combined with pre-anesthetic agents in domestic pigeons (Columba livia). Iranian Journal of Veterinary Surgery, 14(2), 105-115. https://doi.org/10.22034/ivsa.2019.173611.1177
  16. Priscilla, J., Dressen, J. W., Mary, J. D. (1999). The effects of isoflurane anesthesia on hematologic and plasma biochemical values of American kestrels (Falco sparverius). Journal of Avian Medicine and Surgery, 13(3),173-179.
  17. Rahimzadeh, P., Safari, S., Faiz, S. H. R., & Alavian, S. M. (2014). Anesthesia for patients with liver disease. Hepatitis Monthly, 14(7), e19881. https://doi: 10.5812/hepatmon.19881
  18. Santos, E. A., Monteiro, E. R., Herrera, J. R., Mombach, V. S., Boos, M. Z., Gutierrez, L. G., & Alievi, M. M. (2020). Total intravenous anesthesia in domestic chicken (Gallus gallus domesticus) with propofol alone or in combination with methadone, nalbuphine or fentanyl for ulna osteotomy. Veterinary Anaesthesia and Analgesia, 47(3), 347-355. https://doi.org/10.1016/j.vaa.2020.01.008
  19. Singh, P. M., Johnson, C. B., Gartrell, B., Mitchinson, S., Jacob, A., & Chambers, P. (2017). Analgesic effects of morphine and butorphanol in broiler chickens. Veterinary Anaesthesia and Analgesia, 44(3), 538-545. https://doi.org/10.1016/j.vaa.2016.05.006
  20. Tuzcu, M., Tuzcu, N., Akçakavak, G., & Celik, Z. (2022). Diagnosis of sarcina ventriculi-derived haemorrhagic abomasitis in lambs by histopathology and real-time PCR. Acta Veterinaria Brno, 91(3), 227-233. https://doi.org/10.2754/avb202291030227
  21. Tuzcu, N., Tuzcu, M., & Akçakavak, G. (2020). Sığırlarda farklı pnömoni tiplerinde tümör nekroz faktör alfa (TNFα), malondialdehit (MDA), prokalsitonin ve neopterin düzeylerinin karşılaştırılması. Etlik Veteriner Mikrobiyoloji Dergisi, 31(1), 52-61. https://doi.org/10.35864/evmd.709433
  22. Yaygingul, R., Bozkan, Z., Bulut, O., Yldirim, E. K., & Sarierler, M. (2023). Anaesthesia Comparison of the electrocardiographic findings, heart rates, cloacal temperatures, respiratory rates, and anaesthetic effects of medetomidine ketamine and detomidine-ketamine combination in the buzzards (Buteo buteo). Journal of the Hellenic Veterinary Medical Society, 74(1), 5441-5448. https://doi.org/10.12681/jhvms.29730
  23. Yayla, S., Kamiloğlu, N., Kamiloğlu, A., & Özaydın, İ. (2014). Comparision of ıntravenous and ıntraosseous administration of propofol-ketamine combination for anesthesia in quails (Coturnix coturnix japonica). Kocatepe Veterinary Journal, 7(1), 11-16. https://doi.org/10.5578/kvj.7020