Journals / Journal of advances in vetbio science and techniques / 2026 / Issue: 2

Evaluation of biochemical parameters in sheep during the periparturient period

Berrak Işık Soytürk(KASTAMONU ÜNİVERSİTESİ)0000-0001-6204-1674
Serkan Bozacı(KASTAMONU UNIVERSITY)0000-0002-6239-1567
Abdullah Şimşek(KASTAMONU ÜNİVERSİTESİ, İHSANGAZİ MESLEK YÜKSEKOKULU)0000-0002-4077-3222
Tarık Şafak(KASTAMONU UNIVERSITY)0000-0002-6178-4641
Ömer Deniz(KASTAMONU UNIVERSITY)0000-0002-2981-2032
Pages
—
Publication Date
2026-09-23
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, examining metabolic diseases in the periparturient period of sheep, especially those raised in similar regions and under similar feeding conditions, can provide important information for ensuring healthy reproduction, contributing to animal husbandry, and preventing economic losses in the sector.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:During the periparturient period (before and after birth), metabolic and physiological changes become apparent in sheep, accompanied by increased energy and mineral requirements.
📊
Key Findings & Data:This study examined 14 clinically healthy multiparous Anatolian Merino sheep, aged two to five years and with optimal body condition scores.
💡
Conclusion & Impact:In conclusion, examining metabolic diseases in the periparturient period of sheep, especially those raised in similar regions and under similar feeding conditions, can provide important information for ensuring healthy reproduction, contributing to animal husbandry, and preventing economic losses in the sector.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Biochemical Parameters · Ewes · Gestation

Abstract

During the periparturient period (before and after birth), metabolic and physiological changes become apparent in sheep, accompanied by increased energy and mineral requirements. The negative energy balance and mineral deficiencies that occur during this period can lead to various metabolic diseases, losses in lamb and milk production, and serious economic damage. This study examined 14 clinically healthy multiparous Anatolian Merino sheep, aged two to five years and with optimal body condition scores. The sheep underwent synchronization procedures appropriate for the transition period, followed by mating with rams. Blood samples were collected twice from these sheep during the periparturient period: two weeks before the determined lambing date, and two weeks after birth. Alkaline phosphatase, total calcium, magnesium, glucose, phosphorus, non-esterified fatty acids and beta-hydroxybutyrate levels were then examined. The study found that glucose concentration was high in the sheep during the postpartum period (p < 0.001). No statistically significant differences were found in the other parameters examined (p > 0.05). In conclusion, examining metabolic diseases in the periparturient period of sheep, especially those raised in similar regions and under similar feeding conditions, can provide important information for ensuring healthy reproduction, contributing to animal husbandry, and preventing economic losses in the sector.

🔖

Cite This Article

Soytürk, B. I., Bozacı, S., Şimşek, A., Şafak, T., Tümer, K. Ç., Deniz, Ö. (2026). Evaluation of biochemical parameters in sheep during the periparturient period. Journal of advances in vetbio science and techniques, Issue: 2. https://doi.org/10.31797/vetbio.1914945

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (28)

  1. Aktaş, R. & Pehlivan, E. (2023). A comparative profile of certain biochemical and hematological parameters in Angora and Akkeçi goats during the transition period. Turkish Journal of Veterinary & Animal Sciences, 47(1), 80-90. 10.55730/1300-0128.4271
  2. Al-Hadithy, H. A. H., Badawi, N. M. & Alani, M. (2013). Estimation of Serum Liver Enzymes Activities in Awassi Sheep. The Iraqi Journal of Veterinary Medicine, 37(1), 115-120. https://doi.org/10.30539/iraqijvm.v37i1.343
  3. Balthazar, C. F., Pimentel, T. C., Ferrão, L. L., Almada, C. N., Santillo, A., Albenzio, M., Mollakhalili, N., Mortazavian, A. M., Nascimento, J. S., Silva, M. C., Freitas, M. Q., Sant'Ana, A. S., Granato, D. & Cruz, A. G. (2017). Sheep milk: physicochemical characteristics and relevance for functional food development. Comprehensive Reviews in Food Science and Food Safety, 16(2), 247-262. https://doi.org/10.1111/1541-4337.12250
  4. Caldeira, R. M., Belo, A. T., Santos, C. C., Vazques, M. I. & Portugal, A. V. (2007). The effect of long-term feed restriction and overnutrition on body condition score, blood metabolites and hormonal profiles in ewes. Small Rumininant Research, 68(3), 242-255. https://doi.org/10.1016/j.smallrumres.2005.08.026
  5. Cardoso, F. C., Kalscheur, K. F. & Drackley, J. K. (2020). Symposium review: Nutrition strategies for improved health, production, and fertility during the transition period. Journal of Dairy Science, 103(6), 5684-5693. https://doi.org/10.3168/jds.2019-17271
  6. Çiçek, A., Ayyıldız, M., Erdal, G. & Erdal, H. (2022). The importance and economic analysis of sheep breeding in Türkiye. MAS Journal of Applied Sciences, 7(Special Issue), 1303-1322. https://doi.org/10.5281/ZENODO.7529826
  7. Dann, H. M., Litherland, N. B., Underwood, J. P., Bionaz, M., D’Angelo, A. & Mcfadden, J. W. (2006). Diets during far-off and close-up dry periods affect periparturient metabolism and lactation in multiparous cows. Journal of Dairy Science, 89(9), 3563-3577. https://doi.org/10.3168/jds.S0022-0302(06)72396-7
  8. Dzadzovski, I., Celeska, I., Ulchar, I., Janevski, A. & Kirovski, D. (2015). Influence of the season on the metabolic profile in Chios sheep. Macedonian Veterinary Review, 38(2), 183-188. htpps://doi.org/10.14432_j.macvetrev.2015.06.048
  9. Ghavipanje, N., Fathi Nasri, M. H., Farhangfar, S. H., Ghiasi, S. E. & Vargas-Bello-Pérez, E. (2021). Regulation of nutritional metabolism in transition dairy goats: energy balance, liver activity, and insulin resistance in response to berberine supplementation. Animals (Basel), 11(8), 2236. 10.3390/ani11082236
  10. Ji, X., Liu, N., Wang, Y., Ding, K., Huang, S. & Zhang, C. (2023). Pregnancy toxemia in ewes: a review of molecular metabolic mechanisms and management strategies. Metabolites, 13(2), 149. https://doi.org/10.3390/metabo13020149
  11. Kaçar, C., Kaya, S., Kuru, M., Erkılıç, E. E., Öğün, M., Oral, H. & Demir, M. C. (2021). Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep. Veterinary World, 14(4), 1002-1006. https://doi.org/10.14202/vetworld.2021.1002-1006
  12. Kaneko, J. J. (2008). Carbohydrate metabolism and ıts diseases. In: J. J. Kaneko, J. W. Harvey, M. L. Bruss (Eds.), Clinical Biochemistry of Domestic Animals (pp. 45-80). Academic press. https://doi.org/10.1016/B978-0-12-370491-7.00003-9
  13. Khatun, A., Wani, G. M., Bhat, J. I. A., Choudhury, A. R. & Khan, M.Z. (2011). Biochemical indices in sheep during different stages of pregnancy. Asian Journal of Animal and Veterinary Advances, 6(2): 175-81. 10.3923/ajava.2011.175.181
  14. Mohammadi, V., Anassori, E., & Jafari, S. (2016). Measure of energy related biochemical metabolites changes during peri-partum period in Makouei breed sheep. Veterinary Research Forum: an International Quarterly Journal, 7(1): 35-39.
  15. Mongini, A. & Van Saun, R. (2023). Pregnancy toxemia in sheep and goats. Veterinary Clinics of North America: Food Animal Practice, 39(2), 275-291. 10.1016/j.cvfa.2023.02.010
  16. Moyano Tapia, J. C., Leib, S. A., Marini, P. R. & Fischman, M. L. (2020). Effect of mineral supplementation on the macromineral concentration in blood in pre-and postpartum blackbelly sheep. Animals, 10(7), 1206. https://doi.org/10.3390/ani10071206
  17. Özyurtlu, N., Gürgöze, S. Y., Bademkıran, S., Şimşek, A. & Çelik, R. (2007). İvesi koyunlarda doğum öncesi ve sonrası dönemdeki bazı biyokimyasal parametreler ve mineral madde düzeylerinin araştırılması. Fırat University Journal of Health Science, 21(1), 33-36.
  18. Raoofi, A., Jafarian, M., Safi, S. & Vatankhah, M. (2013). Fluctuations in energy-related metabolites during the peri-parturition period in Lori-Bakhtiari ewes. Small Rumininat Research, 109(1), 64-68. https://doi.org/10.1016/j.smallrumres.2012.06.012
  19. Rayan, M., El-abedeen, A. E. Z. & Ellah, M. F. A. (2019). Some metabolic parameters during transition period in dairy cows with and without retained fetal membranes. Journal of Advanced Veterinary Research, 9(2), 45-48. https://advetresearch.com/index.php/AVR/article/view/346
  20. Simões, J. & Margatho, G. (2024). Metabolic periparturient diseases in small ruminants: an update. Applied Sciences, 14(21), 10073. https://doi.org/10.3390/app142110073
  21. Soares, G. S. L., Souto, R. J. C., Cajueiro, J. F. P., Afonso, J. A. B., Rego, R. O., Macêdo, A. T. M., Soares, P. C. & Mendonça, C. L. (2018). Adaptive changes in blood biochemical profile of dairy goats during the period of transition. Revue de Médecine Vétérinaire, 169, 65-75.
  22. Souto, R. J. C., Afonso, J. A. B., Mendonça, C. L., Dantas, A. F. M., Cajueiro, J. F. P., Gonçalves, D. N. A., Olivera, E. F. & Soares, P. C. (2019). Biochemical, endocrine, and histopathological profile of liver and kidneys of sheep with pregnancy toxemia. Pesquisa Veterinaria Brasileira, 39(10), 780-788. https://doi.org/10.1590/1678-5150-PVB-6400
  23. Topaloğlu, Ö., Şahin, B. & Şahin, İ. (2021). Gebelikte ve laktasyonda mineral metabolizması ve hipoparatiroidizm. Kocaeli Medical Journal, 10(2), 194-204. https://dx.doi.org/10.5505/ ktd.2021.26932
  24. Türkiye İstatistik Kurumu (2026, February). Hayvan Varlığı İstatistikleri. https://istatistik.tarimorman.gov.tr/Sayfa/Detay/2222
  25. Uztimur, M. & Ünal, C. N. (2024) Prevalence of pregnancy toxemia in hair goats in Bingöl province, Türkiye. Fırat University Journal of Health Science, 38(1), 78-81. http://www.fusabil.org
  26. Varanis, L. F. M., Oliveira, K. A., Araújo, C. M., da Cruz, W. F. & Macedo Júnior, G. (2021). Serum biochemical reference ranges for pregnant sheep. Bioscience Journal, 37, e37036. https://doi.org/10.14393/BJ-v37n0a2021-47695
  27. Yeşilkaya, O. F., Soyturk, B. I., Deniz, Y. E., Goren, B. E., Satilmis, F. & Erdem, H. (2025). The effect of carprofen administration post-mating on conception rate in lactating Assaf ewes. Small Rumininant Research, 252, 107577. https://doi.org/10.1016/j.smallrumres.2025.107577
  28. Zamuner, F., DiGiacomo, K., Cameron, A. W. N. & Leury, B. J. (2020). Associations between nonesterified fatty acids, β-hydroxybutyrate, and glucose in periparturient dairy goats. Journal of Dairy Science, 103(7), 6672-6678. https://doi.org/10.3168/jds.2019-17163