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Journals / Journal of advances in vetbio science and techniques / 2026 / Issue: 2

Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis

Murat Kaan Durgut(SELCUK UNIVERSITY)0000-0002-4582-8536
Mahmut Ok(SELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0002-8210-6735
Hatice Betül Şahin(SELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0002-5341-9468
Seyhun Selcen Özvar(SELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0009-0004-6784-0570
Süleyman Serhat İyigün(SELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0002-3270-1931
Pages
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Publication Date
2026-05-07
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, the HCO₃/lactate ratio is a valuable prognostic marker reflecting the metabolic acidosis and poor tissue perfusion.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Canine parvoviral enteritis is a viral infection characterized by severe hemorrhagic gastroenteritis, leading to metabolic and electrolyte disturbances and high mortality.
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Key Findings & Data:The study population consisted of 35 dogs, 25 with parvoviral enteritis and 10 clinically healthy dogs.
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Conclusion & Impact:In conclusion, the HCO₃/lactate ratio is a valuable prognostic marker reflecting the metabolic acidosis and poor tissue perfusion.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Canine parvoviral enteritis · Bicarbonate-to-lactate ratio · Blood gas analysis

Abstract

Canine parvoviral enteritis is a viral infection characterized by severe hemorrhagic gastroenteritis, leading to metabolic and electrolyte disturbances and high mortality. The study aimed to evaluate blood gas parameters and the bicarbonate-to-lactate (HCO₃/lactate) ratio for predicting mortality in dogs with parvovirus. The study population consisted of 35 dogs, 25 with parvoviral enteritis and 10 clinically healthy dogs. Venous blood gas analysis, including acid-base parameters, electrolytes, and lactate concentrations, was performed at time of admission. Lactate concentrations were significantly higher in non-survivor (n=12) dogs compared to survivor (n=13) and healthy dogs (p<0.001), while base excess in blood concentrations were lower (p=0.018). Additionally, the HCO₃/lactate ratio was significantly lower in non-survivor dogs compared to survivors. In dogs with parvoviral enteritis, pCO2, sodium and chloride levels were significantly lower compared to the healthy group (p<0.05). Receiver operating characteristic (ROC) analysis revealed cut-off values of 6.03 for the HCO₃/lactate ratio (area under the curve [AUC]: 0.763, p = 0.014) and 3.29 mmol/L for lactate (AUC: 0.776, p = 0.009) for predicting mortality. In conclusion, the HCO₃/lactate ratio is a valuable prognostic marker reflecting the metabolic acidosis and poor tissue perfusion. This ratio is a useful parameter in clinical practice and can be evaluated together with individual blood gas parameters to improve mortality prediction.

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Cite This Article

Durgut, M. K., Ok, M., Şahin, H. B., Özvar, S. S., İyigün, S. S. (2026). Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis. Journal of advances in vetbio science and techniques, Issue: 2. https://doi.org/10.31797/vetbio.1885355

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References (25)

  1. Acharya, C. P., Yadav, A., Pokhrel, S., Bastola, S., & Jha, S. (2025). Prognostic significance of lactate/albumin ratio in respiratory failure and sepsis. Annals of Medicine, 57(1), 2482024. https://doi.org/10.1080/07853890.2025.2482024
  2. Al-Jaghbeer, M., & Kellum, J. A. (2015). Acid–base disturbances in intensive care patients: Etiology, pathophysiology, and treatment. Nephrology Dialysis Transplantation, 30(7), 1104–1111. https://doi.org/10.1093/ndt/gfu289
  3. Alves, F., Barbosa, B., Coelho, N., Pinto, P., Campos, M., Horta, R., Freitas, P., Beier, S., & Paes, P. (2019). Clinical and hematological prognostic factors in dogs with parvoviral enteritis and sepsis. Semina: Ciências Agrárias, 40(4), 1477–1488. https://doi.org/10.5433/1679-0359.2019v40n4p1477
  4. Burchell, R. K., Gal, A., Friedlein, R., & Leisewitz, A. L. (2020). Role of electrolyte abnormalities and unmeasured anions in the metabolic acid–base abnormalities in dogs with parvoviral enteritis. Journal of Veterinary Internal Medicine, 34(2), 857–866.
  5. Decaro, N., & Buonavoglia, C. (2012). Canine parvovirus: A review of epidemiological and diagnostic aspects, with emphasis on type 2c. Veterinary Microbiology, 155(1), 1–12. https://doi.org/10.1016/j.vetmic.2011.09.007
  6. Dik, I., Gülersoy, E., & Şimşek, A. (2024). Importance of biomarkers and cytokines in the prognosis of canine parvovirus infection. Pakistan Veterinary Journal, 44(3). https://doi.org/10.29261/pakvetj/2024.214
  7. Er, C., & Ok, M. (2015). Levels of cardiac biomarkers and coagulation profiles in dogs with parvoviral enteritis. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 21, 383–388.
  8. Gharipour, A., Razavi, R., Gharipour, M., & Mukasa, D. (2020). Lactate/albumin ratio: An early prognostic marker in critically ill patients. The American Journal of Emergency Medicine, 38(10), 2088–2095. https://doi.org/10.1016/j.ajem.2020.06.067
  9. Giani, D., Santoro, M., Gabrielli, M., Di Luca, R., Malaspina, M., Lumare, M., Scatà, L., Pala, M., Manno, A., Candelli, M., Covino, M., Gasbarrini, A., & Franceschi, F. (2025). The role of venous blood gas analysis in critical care: A narrative review. Medicina, 61(8), 1337. https://doi.org/10.3390/medicina61081337
  10. Gonzalez, A., & Waddell, L. (2016). Blood gas analyzers. Topics in Companion Animal Medicine, 31(1), 27–34. https://doi.org/10.1053/j.tcam.2016.05.001
  11. Gülersoy, E., Balıkçı, C., Günal, I., & Şahan, A. (2022). Evaluation of the efficacy of blood gases and hemogram parameters in the diagnosis of non-neurogenic distemper and parvoviral enteritis in dogs with acute gastroenteritis. Revista Científica de la Facultad de Ciencias Veterinarias, 32, 1-8. https://doi.org/10.52973/rcfcv-e32091
  12. Kandilcik, M., Arslan, M., Öksüz, H., Gişi, G., Yavuz, C., Öksüz, G., & Doğaner, A. (2024). Evaluation of the factors affecting mortality after cardiac arrest: Do lactate and procalcitonin concentrations have any implications? European Review for Medical and Pharmacological Sciences, 28(9), 3430–3438. https://doi.org/10.26355/eurrev_202405_36188
  13. Koral, E., & Sevinç, M. (2025). Evaluation of von Willebrand factor in dogs with parvoviral enteritis. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 72(2), 139-144. https://doi.org/10.33988/auvfd.1438635
  14. Li, H., Li, S., Pan, Y., & Shi, Q. (2025). Decoding canine parvovirus: Biomarkers for diagnosis and advances in vaccine development to address emerging challenges. Frontiers in Veterinary Science, 12, 1624275. https://doi.org/10.3389/fvets.2025.1624275
  15. Mylonakis, M. E., Kalli, I., & Rallis, T. S. (2016). Canine parvoviral enteritis: An update on the clinical diagnosis, treatment, and prevention. Veterinary Medicine (Auckland, N.Z.), 7, 91–100. https://doi.org/10.2147/VMRR.S80971
  16. Navya, E., Vinodkumar, K., Davis, J., & Priya, P. (2022). Prognostication of haemato-biochemical, electrolyte and blood gas parameters in canine parvoviral enteritis. Journal of Veterinary and Animal Sciences, 53(3), 333-339. https://doi.org/10.51966/jvas.2022.53.3.333-339
  17. Nguyen Tat, T., Vo Hoang-Thien, N., Nguyen Tat, D., Nguyen, P. H., Ho, L. T., Doan, D. H., Phan, D. T., Duong, Y. N., Nguyen, T. H., Nguyen, T. K., Dinh, H. T., Dinh, T. T., Pham, A. T., Do Chau, V., Trinh, T. H., & Vo Thanh, L. (2024). Prognostic values of serum lactate-to-bicarbonate ratio and lactate for predicting 28-day in-hospital mortality in children with dengue shock syndrome. Medicine, 103(17), e38000. https://doi.org/10.1097/MD.0000000000038000
  18. Paul, B., De, U., Sarkar, V., Gandhar, J., Patra, M., Agrawal, R., Singh, M., Soni, S., & Eregowda, C. (2023). Effect of systemic inflammatory response syndrome on thrombocytogram, acute phase proteins, electrolytes, acid–base indices and cytokine expression in naturally canine parvovirus infected dogs. Veterinary Immunology and Immunopathology, 259, 110598. https://doi.org/10.1016/j.vetimm.2023.110598
  19. Pinelo, A., Loureiro, L., Pires, M., Mendes, D., Almeida, H., Queirós, M., Cabral, J., Cardoso, S., & Machado, R. (2025). Prognostic value of the HCO₃-to-lactate ratio in acute mesenteric ischemia: A retrospective analysis. Annals of Vascular Surgery, 117, 19–27. https://doi.org/10.1016/j.avsg.2025.03.026
  20. Prittie, J. (2004). Canine parvoviral enteritis: a review of diagnosis, management, and prevention. Journal Of Veterinary Emergency and Critical Care, 14(3), 167-176. https://doi.org/10.1111/j.1534-6935.2004.04020.x
  21. Smuszkiewicz, P., Jawień, N., Szrama, J., Lubarska, M., Kusza, K., & Guzik, P. (2022). Admission lactate concentration, base excess, and alactic base excess predict the 28-day inward mortality in shock patients. Journal of Clinical Medicine, 11(20), 6125. https://doi.org/10.3390/jcm11206125
  22. Ukwueze, C., Akpan, E., Ezeokonkwo, R., Nwosuh, C., & Anene, B. (2020). Haematological, oxidative stress and electrolyte alterations in puppies with canine parvoviral enteritis. Iraqi Journal of Veterinary Sciences, 34(1), 65–69. https://doi.org/10.33899/ijvs.2019.125582.1094
  23. Venn, E., Barnes, A., Hansen, R., Boscan, P., Twedt, D., & Sullivan, L. (2020). Serum D-lactate concentrations in dogs with parvoviral enteritis. Journal of Veterinary Internal Medicine, 34(2), 691–699. https://doi.org/10.1111/jvim.15688
  24. Zhou, Z., Shi, X., Li, K., Hu, Q., Ren, Y., Zhou, X., Li, M., Zhang, T., Yang, F., Huang, Y., Wang, C., Li, D., Zhong, Z., Liu, H., Li, C., He, T., & Peng, G. (2025). First identification of CPV-2c infection in a wild cub giant panda (Ailuropoda melanoleuca) suggesting an emerging transmission from wildlife and domestic dogs. Transboundary and Emerging Diseases, 2025, 6716483. https://doi.org/10.1155/tbed/6716483
  25. Zhu, J. L., Liu, H., Wang, L. L., Lu, X. H., Yin, H. Y., Lyu, J., & Wei, J. R. (2022). Association of lactate-to-albumin ratio and bicarbonate with short-term mortality risk in patients with acute myocardial infarction. BMC Cardiovascular Disorders, 22(1), 490. https://doi.org/10.1186/s12872-022-02902-4