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Journals / Hitit Medical Journal / 2026 / Cilt: 8 Sayı: 1

A Novel Electrocardiographic Parameter for Predicting Left Ventricular Hypertrophy in Hypertensive Patients: Ventricular Activation Time

Hipertansif Hastalarda Sol Ventrikül Hipertrofisini Öngörmede Yeni Bir Elektrokardiyografik Parametre: Ventriküler Aktivasyon Zamanı

Mucahit Yetim(HİTİT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-2444-7523
Macit Kalçık(HİTİT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8791-4475
Lütfü Bekar(HİTİT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-3920-1382
Muhammet Cihat Çelik(Hitit University Corum Erol Olçok Education and Research Hospital)0000-0002-6496-7849
Pages
75–84
Publication Date
2026-02-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Larger, multicenter studies are warranted to further validate its diagnostic and prognostic value.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to investigate the relationship between electrocardiographic parameters and left ventricular hypertrophy (LVH) in patients with hypertension, and to evaluate the diagnostic value of ventricular activation time (VAT).
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Key Findings & Data:Material and Method: A total of 320 patients with essential hypertension (mean age 61.9±7.8 years, 57.5% male) were enrolled.
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Conclusion & Impact:Larger, multicenter studies are warranted to further validate its diagnostic and prognostic value.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Hipertansiyon · Sol ventrikül hipertrofisi · Ventriküler aktivasyon zamanı

Abstract

Objective: The aim of this study was to investigate the relationship between electrocardiographic parameters and left ventricular hypertrophy (LVH) in patients with hypertension, and to evaluate the diagnostic value of ventricular activation time (VAT). Material and Method: A total of 320 patients with essential hypertension (mean age 61.9±7.8 years, 57.5% male) were enrolled. All patients underwent transthoracic echocardiography and 12-lead high-resolution electrocardiography. Patients were divided into two groups according to the presence of LVH on echocardiography. Demographic, laboratory, echocardiographic, and electrocardiographic parameters were compared. Independent predictors were determined using multivariate logistic regression and ROC curve analysis. Results: LVH was detected in 114 patients (35.6%). The LVH (+) group had significantly larger left atrial diameter, interventricular septal thickness, posterior wall thickness, left ventricular mass, and mass index (all p 30 ms predicted LVH with 67% sensitivity and 59% specificity (AUC=0.681; p<0.001). Conclusion: VAT is an independent predictor of left ventricular hypertrophy in hypertensive patients. Due to its ease of measurement and lack of additional cost, VAT may serve as a practical parameter in clinical practice alongside echocardiography. Larger, multicenter studies are warranted to further validate its diagnostic and prognostic value.

Özet

Amaç: Hipertansiyon hastalarında elektrokardiyografik parametreler ile sol ventrikül hipertrofisi (SVH) arasındaki ilişkinin araştırılması ve özellikle ventriküler aktivasyon zamanının (VAT) tanısal değerinin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Esansiyel hipertansiyonu olan 320 hasta (ortalama yaş 61,9±7,8 yıl, %57,5 erkek) çalışmaya dahil edildi. Tüm hastalara transtorasik ekokardiyografi ve 12 derivasyonlu yüksek çözünürlüklü EKG çekildi. Hastalar ekokardiyografide SVH varlığına göre iki gruba ayrıldı. Demografik, laboratuvar, ekokardiyografik ve elektrokardiyografik parametreler karşılaştırıldı. Çok değişkenli lojistik regresyon ve ROC analizleri ile bağımsız öngördürücü parametreler belirlendi. Bulgular: Hastaların 114’ünde (%35,6) SVH saptandı. SVH (+) grupta sol atriyum çapı, interventriküler septal kalınlık, arka duvar kalınlığı, sol ventrikül kütlesi ve kitle indeksi anlamlı olarak daha yüksekti (tümü p 30 ms için %67 duyarlılık ve %59 özgüllük elde edildi (AUC=0,681; p<0,001). Sonuç: Hipertansif hastalarda VAT, sol ventrikül hipertrofisini öngörmede bağımsız bir parametredir. Kolay ölçülebilir ve ek maliyet gerektirmemesi nedeniyle, ekokardiyografiye ek olarak klinik uygulamada kullanılabilecek pratik bir belirteçtir. Daha geniş ve çok merkezli çalışmalarla tanısal ve prognostik değerinin doğrulanması gerekmektedir.

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Cite This Article

Yetim, M., Kalçık, M., Bekar, L., Çelik, M. C. (2026). A Novel Electrocardiographic Parameter for Predicting Left Ventricular Hypertrophy in Hypertensive Patients: Ventricular Activation Time. Hitit Medical Journal, Cilt: 8 Sayı: 1, 75–84. https://doi.org/10.52827/hititmedj.1774845

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