Journals / Bakırköy Tıp Dergisi / 2013 / Cilt: 9 - Sayı: 3

Endometrial carcinomas based on polyp: 3 years single center experience

Endometriyal Polip Zemininde Gelişen Endometriyum Kanserleri: 3 Yıllık Klinik Deneyimimiz

Pages
116–120
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Eventhoug malign endometrial polyps are diagnosed at eraly stages, with the advanced age grade of the tumor increases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The incidence of endometrial polyp is 16-34% within the whole population nonetheless increases after menopause.
📊
Key Findings & Data:The incidence of cancer involvement through the endometrial polyp is 0.8-4.8%.
💡
Conclusion & Impact:Eventhoug malign endometrial polyps are diagnosed at eraly stages, with the advanced age grade of the tumor increases.
🔬Design:Review & Systematic Survey
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The incidence of endometrial polyp is 16-34% within the whole population nonetheless increases after menopause. The incidence of cancer involvement through the endometrial polyp is 0.8-4.8%. Material and Methods: Study is designed as a retrospective descriptive study. Medical records of the patients which were diagnosed to have endometrial polyp within January 2009-January 2012 were reviewed. The patients which were diagnosed to have malignancy based on endometrial polyp were included. Results: 325 patients were obtained to have endometrial polyp, and 11 of them (3.4%) were found to be appropriate for study. 140 patients (59%) were postmenopousal and 285 patients (41%) were premenopousal 67 (43%) of the postmenopausal patients had endometrial sampling due to thickened endometrium (10mm) although they were asymptomatic. 73 (57%) of the postmanopausal patients were symptomatic. Six of this postmenouposal patients (4.2%) had malignancy based on the endometrial polyp, all of this patients were in symtomatic group. 192 of the 325 patients (59%) were symptomatic and 10 of this patients (5.2%) had malignancy based on endometrial polyp. Only one patient was asymptomatic. Histopathologic type was endometrioid and except one patient who has stage 1B disease, all patients have stage 1A disease. Two patients’ carcinoma were limited to the polyp, endometrial tissue had no sign of malignancy. Conclusion: We conclude that endometrial biopsy should be performed at the patients known to have endometrial polyp after menopause and symptomatic patient, regardless the menopausal status. Eventhoug malign endometrial polyps are diagnosed at eraly stages, with the advanced age grade of the tumor increases.

Özet

Amaç: Endometriyal poliplerin toplumda görülme sıklığı %16-34 arasında olmakla birlikte, menopoz dönemi ve sonrasında görülme sıklığı artar. Endometriyal polip zemininde kanser gelişme sıklığı %0.8-4.8’dir. Gereç ve Yöntem: Çalışma, geriye dönük tanımlayıcı bir çalışma olarak düzenlendi. Ocak 2009-Ocak 2012 tarihleri arasında kliniğimizde endometriyal polip tanısı alan hastaların tıbbi kayıtları gözden geçirildi. Bu hastalar arasından, endometriyal polip zemininde endometriyal kanser geliştiği tespit edilenler seçilerek çalışmaya dahil edildi. Bulgular: Endometriyal polip tanısı alan toplam 325 hastanın kayıtlarına ulaşıldı. Hastalar arasından 11 tanesi (%3.4) polip zemininde adenokarsinom geliştiği tespit edilerek çalışma kriterlerine uygun bulundu. Hastaların 140 tanesi (%59) postmenopozal, 285 (%41) tanesi premenopozal dönemdeydi. Postmenopozal 140 hastanın 67 tanesinde (%43) herhangi bir semptom yoktu, sonografide endometriyum kalınlığı 10 mm üzerinde olduğu için örnekleme yapıldı. Geriye kalan postmenopozal 73 (%57) hastada kanama şikayeti mevcuttu. Postmenopozal dönemdeki bu hastaların altısında (%4.2) polip zemininde adenokarsinom tespit edildi, 6 hasta da semptomatik gruptaydı. Geriye kalan 5 hasta premenopozal dönemdeydi ve bu hastalardan 4 tanesinde anormal uterin kanama varken 1 hastada herhangi bir şikayet yoktu. 325 hastanın içinde anormal uterin kanama tarifleyen 192 (%59) hasta mevcuttu ve anormal uterin kanamalı bu hastaların 10 tanesinde (%5.2) polip zemininde adenokarsinom geliştiği tespit edildi. Geriye kalan bir hastanın herhangi bir semptomu yoktu. Tüm hastaların histopatolojik inceleme sonucu endometrioid tipti ve FIGO 2009 evreleme sistemine göre yapılan evrelemede 1 hasta evre 1B çıkarken diğer 10 hasta Evre 1A olarak tanı aldı. Evre 1A çıkan 10 hastadan iki tanesinde karsinomun sadece polibe sınırlı olduğu, çevre endometriyum dokusunun salim olduğu görüldü. Hastaların ortalama yaşı 58.72 (40-78) idi. Sonuç: Postmenopozal dönemde olan veya klinik bir şikayetle başvuran ve endometriyal polip saptanan hastalarda doku örneklemesinin mutlaka göz önüne alınması gerektiğini düşünüyoruz. Endometriyal polip zemininde gelişen kanserler genellikle erken evrede teşhis edilmelerine rağmen, ileri yaşla birlikte tümör derecesi yükselmektedir.

🔖

Cite This Article

GÖNENÇ, G., GÜDÜCÜ, N., İŞÇİ, H., BAŞGÜL, A. Y., DÜNDER, İ., TÜRKMEN, İ., BAŞSÜLLÜ, N., AYDINLI, K. (2013). Endometrial carcinomas based on polyp: 3 years single center experience. Bakırköy Tıp Dergisi, Cilt: 9 - Sayı: 3, 116–120. https://ajindex.com/articles/132743

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Peterson WF, Novak ER. Endometrial polyps. Obstet Gynecol 1956; 8: 40-49
  2. Sherman ME, Mazur MT, Kurman RJ. Benign diseases of the endometrium Kurman RJ (Ed), Blaustein’s pathology of the female genital tract. Springer-Verlag, New York. 2002: p. 421-426
  3. Hileeto D, Fadare O, Martel M, Zheng W. Age dependent association of endometrial polyps with increased risk of cancer involvement. World J Surg Oncol 2005; 3: 8
  4. Orvieto R, Bar-Hava I, Dicker D, Bar J, Ben-Rafael Z, Neri A. Endometrial polyps during menopause: characterization and significance. Acta Obstet Gynecol Scand 1999; 78: 883-886
  5. Savelli L, De Iacco P, Santini D et al. Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps Am J Obstet Gynecol 2003; 188: 927-931
  6. Perri T, Rahimi K, Ramanakumar AV, et al. Are endometrial polyps true cancer precursors? Am J Obstet Gynecol 2010; 232: e1-6
  7. Tabrizi AD, Vahedi A, Esmaily HA. Malignant endometrial polyps: Report of two cases and review of literature with emphasize on recent advances. J Res Med Sci 2011; 16: 574-579
  8. Scully RE, Bonfiglio TA, Kurman RJ (Eds). World Health Organization International Histologic Classification of Tumors. Histologic Typing of Female Genital Tract Tumors. 1994; Berlin, Germany, Springer- Verlag 9. Clement PB, Young RH. Non-endometrioid carcinomas of the uterine corpus: a review of their pathology with emphasis on recent advances and problematic aspects. Adv Anat Pathol 2004; 11: 117-142
  9. Antunes A Jr, Costa-Paiva L, Arthuso M, Costa JV, Pinto-Neto AM. Endometrial polyps in pre- and postmenopausal women: factors associated with malignancy. Maturitas 2007; 57: 415-21
  10. Ben-Arie A, Goldchmit C, Laviv Y, et al. The malignant potential of endometrial polyps. Eur J Obstet Gynecol Reprod Biol 2004; 115: 206-210
  11. Fernández-Parra J, Rodríguez Oliver A, López Criado S, Parrilla Fernández F, Montoya Ventoso F. Hysteroscopic evaluation of endometrial polyps. Int J Gynaecol Obstet 2006; 95: 144-148
  12. Trahan S, Têtu B, Raymond PE. Serous papillary carcinoma of the endometrium arising from endometrial polyps: a clinical, histological, and immunohistochemical study of 13 cases. Hum Pathol 2005; 36: 1316-1321
  13. Kelly P, Dobbs SP, McCluggage WG. Endometrial hyperplasia involving endometrial polyps: report of a series and discussion of the significance in an endometrial biopsy specimen. BJOG 2007; 114: 944-950
  14. Perez-Medina T, Bajo J, Huertas MA, Rubio A.