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Journals / Journal of Clinical and Experimental Investigations / 2026 / Cilt: 3 Sayı: 2

First trimester serum PAPP-A levels and the prediction of small-for-gestational age infants

İlk trimester serum PAPP-A düzeyleri ve gebelik yaşına göre küçük bebeklerin tahmin edilmesi

Nilgün Güdücü
Gökçenur Gönenç
Herman İşçi
Alin Başgül Yiğiter
İlkkan Dünder
Pages
185–188
Publication Date
2012-06-01
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J Clin Exp Invest 2012; 3(2): 185-188

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of this study was to detect the predictive value of PAPP-A in small-for-gestational age (SGA) infants.
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Key Findings & Data:PAPP-A levels less than 5th percentile were considered as predictive of SGA infants.
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Conclusion & Impact:J Clin Exp Invest 2012; 3(2): 185-188
🔬Design:Makale
📍Scope:2012 Verileri
⚙️Variables:gebelik yaşına göre küçük bebek · PAPP-A · gebelik

Abstract

Objectives: The aim of this study was to detect the predictive value of PAPP-A in small-for-gestational age (SGA) infants. Materials and methods: We retrospectively searched the patient charts of our hospital for first trimester Down syndrome screening test results. PAPP-A levels less than 5th percentile were considered as predictive of SGA infants. Results: Low PAPP-A levels were associated with SGA infants, sensitivity was 3,5%, specificity 90%, positive predictive value 1,6% and negative predictive value 95%. Conclusions: The low positive predictive value of PAPP-A prevents it from being used as a screening test for the detection of SGA infants. J Clin Exp Invest 2012; 3(2): 185-188

Özet

Amaç: Bu çalışmanın amacı ilk trimester serum PAPP-A (pregnancy aasociated plasma protein A) seviyelerinin gebelik yaşına göre küçük (GYK) bebekleri tahmin etmede kullanılabilirliğini tespit etmektir. Gereç ve yöntem: Geriye dönük olarak hastanemizin gebe kayıtları incelendi ve ilk trimester Down sendromu tarama testlerinin sonuçları bulundu. PAPP-A seviyeleri 5. persentilin altında kalanlar GYK bebek olarak kabul edildi. Bulgular: Düşük PAPP-A seviyeleri ile GYK bebekler arasında bir ilişki mevcuttur, testin duyarlılığı %3,5, özgüllüğü %90, pozitif kestirim değeri %1,6 ve negatif kestirim değeri %95tir. Sonuç: Testin pozitif kestirim değerinin düşük olması nedeniyle GYK bebekleri tahmin etmek için kullanılması uygun değildir.

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Cite This Article

Güdücü, N., Gönenç, G., İşçi, H., Yiğiter, A. B., Dünder, İ. (2012). First trimester serum PAPP-A levels and the prediction of small-for-gestational age infants. Journal of Clinical and Experimental Investigations, Cilt: 3 Sayı: 2, 185–188. https://doi.org/10.5799/ahinjs.01.2012.02.0141

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