Journals / Bakırköy Tıp Dergisi / 2019 / Cilt: 15 - Sayı: 2

Predictive Value of Presepsin in Determining Leaks After Laparoscopic Sleeve Gastrectomy: A Pilot Study

Laparoskopik Sleeve Gastrektomi Sonrası Kaçakların Tespitinde Presepsinin Tanısal Değeri: Pilot Çalışma

Pages
175–181
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Increased levels of presepsin, especially on the first day of surgery, may play an important role for early detection of possible postoperative complications without clinical reflection.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Laparoscopic sleeve gastrectomy (LSG) is among the most effective surgical interventions in the long-term prevention of morbid obesity.
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Key Findings & Data:Methods: Sixty patients with LSG due to morbid obesity and 40 controls were included in this prospective study, which was carried out between April 2016 and July 2016 in our clinic.
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Conclusion & Impact:Increased levels of presepsin, especially on the first day of surgery, may play an important role for early detection of possible postoperative complications without clinical reflection.
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: Laparoscopic sleeve gastrectomy (LSG) is among the most effective surgical interventions in the long-term prevention of morbid obesity. Stapler line leaks and stapler line bleedings are important complications, which affect morbidity and mortality. The aim of this study is to determine the role of plasma presepsin levels for detection of stapler leaks. Methods: Sixty patients with LSG due to morbid obesity and 40 controls were included in this prospective study, which was carried out between April 2016 and July 2016 in our clinic. Patients were evaluated by a multidisciplinary team before surgery in accordance with the protocol of our hospital. Blood samples were obtained from patients without any medical treatment 12 hours before operation and 1st, 3rd, and 5th days postoperatively. Plasma presepsin levels, along with white blood counts (WBC, leukocyte), C-reaktive protein (CRP) and Neutrophil-Lymphocyte Ratio (NLR), were evaluated in patients who had sleeve gastrectomy line leakage. Results: In cases with complications, postoperative leukocyte count, CRP, NLR and presepsin measurements on the 1., 3. and 5. day were found higher than the group without complications. The predictive level of presepsin (p=0.006), CRP (p=0.023) and NLR (p=0.035) was found significantly higher than leukocyte (p<0.05) . Conclusions: Our study indicates a role of presepsin levels in the detection and follow up of stapler line leaks following LSG. Increased levels of presepsin, especially on the first day of surgery, may play an important role for early detection of possible postoperative complications without clinical reflection.

Özet

Amaç: Laparoskopik sleeve gastrektomi (LSG), morbid obezitenin uzun süreli önlenmesinde en etkili cerrahi girişimler arasındadır. Zımba hattı sızıntıları ve kanamaları, morbidite ve mortaliteyi etkileyen önemli komplikasyonlardır. Bu çalışmanın amacı, zımba hattı sızıntılarının tespiti için plazma presepsin düzeylerinin rolünü belirlemektir. Yöntemler: Nisan 2016-Temmuz 2016 tarihleri arasında kliniğimizde yürütülen bu prospektif çalışmaya morbid obezite nedeniyle LSG olan 60 hasta ve 40 kontrol dahil edildi. Hastalar hastanemiz protokolüne uygun olarak ameliyat öncesi multidisipliner bir ekip tarafından değerlendirildi. Ameliyattan 12 saat önce ve postoperatif 1., 3. ve 5. günlerde herhangi bir medikal tedavi olmayan hastalardan kan örnekleri alındı. Plazma presepsin düzeyleri, beyaz kan sayımı (WBC, lökosit), C-reaktif protein (CRP) ve nötrofil-lenfosit oranı (NLR) ile birlikte, sleeve gastrektomi hattı kaçağı olan hastalarda değerlendirildi. Bulgular: Komplikasyonsuz olgularda postoperatif lökosit sayısı, CRP, NLR ve presepsin ölçümleri 1.gün, 3.gün ve 5. günlerde komplikasyonsuz gruptan daha yüksek bulundu. Presepsin prediktif düzeyi (p=0,006), CRP (p=0,023) ve NLR (p=0,035) lökositlerden anlamlı derecede yüksek bulundu (p<0,05). Sonuç: Çalışmamızda, LSG sonrası zımba hattı sızıntılarının saptanması ve takibinde presepsin düzeylerinin rolü gösterilmiştir. Özellikle ameliyatın ilk gününde, presepsin düzeylerinin artması, klinik yansıma olmaksızın olası postoperatif komplikasyonların erken saptanmasında önemli bir rol oynayabilir.

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Cite This Article

BİNBOĞA, S., IŞIKSAÇAN, N., ÇİKOT, M., KÖNEŞ, O., BİNBOĞA, E., KARABULUT, M., ŞAHBAZ, N. A., BOZKURT, M. A., ALIŞ, H. (2019). Predictive Value of Presepsin in Determining Leaks After Laparoscopic Sleeve Gastrectomy: A Pilot Study. Bakırköy Tıp Dergisi, Cilt: 15 - Sayı: 2, 175–181. https://ajindex.com/articles/125710

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