Journals / Türk Biyokimya Dergisi / 2019 / Cilt: 44 - Sayı: 4

Plasma presepsin in determining gastric leaks following bariatric surgery

Bariatrik cerrahiyi takip eden gastrik kaçakların belirlenmesinde plazma presepsin düzeyleri

Pages
565–573
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Elevated presepsin levels,on postoperative day 1 in particular, could have a key rolein the early detection of possible complications which arenot seen clinically.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: To be able to prevent morbid obesity in thelong-term, laparoscopic sleeve gastrectomy (LSG) is one ofthe most effective surgical interventions.
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Key Findings & Data:However, leakageand bleeding from the stapler line are significant complications.
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Conclusion & Impact:Elevated presepsin levels,on postoperative day 1 in particular, could have a key rolein the early detection of possible complications which arenot seen clinically.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: To be able to prevent morbid obesity in thelong-term, laparoscopic sleeve gastrectomy (LSG) is one ofthe most effective surgical interventions. However, leakageand bleeding from the stapler line are significant complications. The aim of this study was to determine the role of thelevels of plasma presepsin in the detection of stapler leakage.Materials and methods: The study included 300 patientswith LSG due to morbid obesity and 40 control subjects.Before any medical treatment was applied, blood sampleswere taken from patients at 12 h preoperatively and ondays 1, 3, and 5 postoperatively. Evaluation was made ofplasma presepsin levels, white blood count (WBC), C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR),in all patients with sleeve gastrectomy line leakage.Results: The WBC, CRP, NLR and presepsin values measured on days 1, 3 and 5 postoperatively were determined to be higher in patients with leakage compared to thosewithout. The predictive value of presepsin (p = 0.001), CRP(p = 0.001) and NLR (p = 0.001) was determined to be statistically significantly higher than that of WBC (p = 0.01).Conclusion: The results of the study suggest that presepsin levels could have a role in the detection and follow-upof stapler line leaks after LSG. Elevated presepsin levels,on postoperative day 1 in particular, could have a key rolein the early detection of possible complications which arenot seen clinically.

Özet

Amaç: Laparoskopik sleeve gastrektomi (LSG), uzun vadede morbid obeziteyi önlemek için en etkili cerrahi girişimlerden biridir. Bununla birlikte, zımba hattından sızıntı ve kanama önemli komplikasyonlardır. Bu çalışmanın amacı, stapler hattı sızıntısının tespitinde plazma presepsin düzeylerinin rolünü belirlemektir. Gereç ve Yöntem: Çalışmaya morbid obezite nedeniyle LSG’li 300 hasta ve 40 kontrol olgusu dahil edildi. Herhangi bir medikal tedavi uygulanmadan, preoperatif 12 saat önce ve postoperatif 1., 3. ve 5. günlerde kan örnekleri alındı. Sleeve gastrektomi hattı sızıntısı olanlarla beraber tüm hastalarda plazma presepsin düzeyleri, beyaz kan sayımı (WBC), C-reaktif protein (CRP) ve Nötrofil-Lenfosit oranı (NLR) değerlendirildi. Bulgular: Postoperatif 1., 3. ve 5. günlerde ölçülen WBC, CRP, NLR ve Presepsin değerlerinin sızıntı olan hastalarda, olmayanlara göre daha yüksek olduğu belirlendi. Presepsinin prediktif değeri (p = 0.001), CRP (p = 0.001) ve NLR (p = 0.001), WBC’den istatistiksel olarak anlamlı derecede yüksek bulundu (p = 0.01). Sonuç: Çalışmanın sonuçları presepsin düzeylerinin, LSG sonrası oluşan zımba hattı kaçaklarının saptanmasında ve izlenmesinde rol oynayabileceğini düşündürmektedir. Yükselen presepsin düzeylerinin, özellikle postoperatif 1. günde, klinik olarak görülmeyen olası komplikasyonların erken tespitinde anahtar rol oynayabilir.

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Cite This Article

ÇİKOT, M., KASAPOĞLU, P., KOŞER, M., BİNBOĞA, S., BİNBOĞA, E., ALIŞ, H., IŞIKSAÇAN, N., SARAÇ, E. Y. (2022). Plasma presepsin in determining gastric leaks following bariatric surgery. Türk Biyokimya Dergisi, Cilt: 44 - Sayı: 4, 565–573. https://ajindex.com/articles/620850

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