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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Cilt: 49 Sayı: 2

FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS

MEYVELERDEN ŞİFAYA: PRUNUS CERASIFERA, MALUS SYLVESTRIS VE CORNUS MAS TÜRLERİNDEN ELDE EDİLEN UÇUCU YAĞLAR, YAĞ ASİTLERİ VE SU EKSTRELERİNİN LC-MS VE GC-MS YÖNTEMLERİYLE TERAPÖTİK POTANSİYELLERİNİN ANALİZİ

Bilge Aydın(ERZINCAN UNIVERSITY)0000-0002-7712-7259
Hafize Yuca(ATATÜRK ÜNİVERSİTESİ)0000-0002-0857-4776
Gözde Öztürk(ANADOLU UNIVERSITY)0000-0002-3998-8859
Enes Tekman(ATATÜRK ÜNİVERSİTESİ)0000-0002-1226-7218
Songül Karakaya(Atatürk Üniversitesi)0000-0002-3268-721X
Gamze Göger(Afyonkarahisar Sağlık Bilimleri Üniversitesi)0000-0003-2978-5385
Mehmet Önal0000-0003-1069-1012
Betül Demirci(ANADOLU UNIVERSITY)0000-0003-2343-746X
Zuhal Güvenalp(ATATÜRK ÜNİVERSİTESİ)0000-0002-8803-8147
Oksana Sytar0000-0003-4219-9292
Pages
402–424
Publication Date
2025-05-19
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

IC50 values further underscore effectiveness of aqueous extracts, especially in cases of C. mas and M. sylvestris with <10 and 399 µg/ml.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The chemical composition and bioactive properties of essential oils, fatty oils and aqueous extracts of Prunus cerasifera, Malus sylvestris and Cornus mas were investigated.
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Key Findings & Data:Result and Discussion: Fatty oils’ major compounds were oleic acid (77.1%) in P. cerasifera, palmitic acid (32.5%) in M. sylvestris fruits, and linoleic acid (43.2%) in C. mas seeds.
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Conclusion & Impact:IC50 values further underscore effectiveness of aqueous extracts, especially in cases of C. mas and M. sylvestris with <10 and 399 µg/ml.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Antidiyabetik · antikolinesteraz · Cornus mas

Abstract

Objective: The chemical composition and bioactive properties of essential oils, fatty oils and aqueous extracts of Prunus cerasifera, Malus sylvestris and Cornus mas were investigated. Material and Method: Antidiabetic, antimicrobial, anticholinesterase and antioxidant activities of P. cerasifera, M. sylvestris and C. mas were reported. The quantitative determination of some secondary metabolites was also analysed by LC-MS/MS. The chemical composition of the essential oils was also investigated by GC-MS. Result and Discussion: Fatty oils’ major compounds were oleic acid (77.1%) in P. cerasifera, palmitic acid (32.5%) in M. sylvestris fruits, and linoleic acid (43.2%) in C. mas seeds. Benzaldehyde (70.1%), nonacosane (30.4%), (E,E)-2,4-Decadienal (43.3%) were found as major compounds of P. cerasifera, M. sylvestris fruits, and C. mas seed essential oils, respectively. Quinic acid was predominant compound in all extracts, ranging from 11262.2996 to 18179.6260 ng/ml. C. mas fatty oil was showed antimicrobial activity against Candida albicans and C. parapsilosis with MIC =625-1250 µg/ml. P. cerasifera, C. mas, and M. sylvestris hold potential as α-glucosidase inhibitors, with varying degrees of potency. IC50 values further underscore effectiveness of aqueous extracts, especially in cases of C. mas and M. sylvestris with <10 and 399 µg/ml.

Özet

Amaç: Prunus cerasifera, Malus sylvestris ve Cornus mas'ın uçucu yağları, yağ asitleri ve sulu ekstrelerinin kimyasal bileşimi ve biyoaktif özellikleri araştırılmıştır. Gereç ve Yöntem: P. cerasifera, M. sylvestris ve C. mas'ın antidiyabetik, antimikrobiyal, antikolinesteraz ve antioksidan aktiviteleri rapor edilmiştir. Ayrıca bazı sekonder metabolitlerin kantitatif tayini LC-MS/MS ile analiz edilmiştir. Uçucu yağların kimyasal bileşimi de GC-MS ile araştırılmıştır. Sonuç ve Tartışma: Yağların ana bileşikleri P. cerasifera'da oleik asit (%77.1), M. sylvestris meyvelerinde palmitik asit (%32.5) ve C. mas tohumlarında linoleik asit (%43.2) olarak bulunmuştur. Benzaldehit (%70.1), nonakozan (%30.4), (E,E)-2,4-dekadienal (%43.3) sırasıyla P. cerasifera, M. sylvestris meyveleri ve C. mas tohum uçucu yağlarının ana bileşikleri olarak bulunmuştur. Kinik asit, 11262.2996 ila 18179.6260 ng/ml arasında değişen tüm ekstrelerde en çok bulunan bileşik olmuştur. C. mas yağı Candida albicans ve C. parapsilosis türlerine karşı MIC =625-1250 µg/ml ile antimikrobiyal aktivite göstermiştir. P. cerasifera, C. mas ve M. sylvestris, değişen derecelerde etki gücüne sahip α-glukozidaz inhibitörleri olarak potansiyel taşımaktadır. Özellikle <10 ve 399 µg/ml olan C. mas ve M. sylvestris örneklerinde IC50 değerleri sulu ekstrelerinin etkinliğini daha da vurgulamaktadır.

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Cite This Article

Aydın, B., Yuca, H., Öztürk, G., Tekman, E., Karakaya, S., Göger, G., Önal, M., Demirci, B., Güvenalp, Z., Sytar, O. (2025). FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 49 Sayı: 2, 402–424. https://doi.org/10.33483/jfpau.1562768

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