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Journals / European Journal of Biology / 2026 / Volume: 83 Issue: 1

Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract

Nguyen Anh Xuan(Hong Bang International University, Faculty Of Medical Laboratory)0009-0001-7545-0888
Nguyen Trung Quan(Vietnam National University Ho Chi Minh City, University of Science, Faculty of Biology and Biotechnology)0000-0002-6436-4693
Bui Thi Kim Ly(Thu Dau Mot University, Department of Medicine and Pharmacy)0000-0002-8433-7035
Hoang Thanh Chi(Thu Dau Mot University, Department of Medicine and Pharmacy)0000-0002-6638-1235
Pages
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Publication Date
2024-05-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The results showed the apoptosis-inducing capacity of the C. kissi extract on K562 cells, and the impact was suggested to be through the induction of intracellular apoptosis and cell cycle arrest.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Camellia kissi, a prominent tea, lacks academic works.
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Key Findings & Data:Results: The results showed the apoptosis-inducing capacity of the C. kissi extract on K562 cells, and the impact was suggested to be through the induction of intracellular apoptosis and cell cycle arrest.
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Conclusion & Impact:Initial recognition of the signaling pathway of inhibition is through the BCR-ABL/PTEN.
🔬Design:Short Communication
📍Scope:Comprehensive Sample
⚙️Variables:Camellia kissi · chronic myeloid leukemia · leukemia

Abstract

Objective: Camellia kissi, a prominent tea, lacks academic works. In a previous report, this plant substantially affected chronic myeloid leukemia cells. Understanding the mechanism of action of this tea species on leukemia cells will contribute to researching alternative treatment methods in the context of drug resistance in chronic myeloid leukemia, which is constantly increasing. Materials and Methods: C. kissi comes from Lam Dong, Vietnam. The crude tea extract in methanol was obtained. The flow cytometry method with Annexin V and PI staining and the DNA fragmentation assays were used to indicate the apoptosis cells. The reversed transcription real-time PCR reactions were conducted to measure the mRNA level under the treatment. Results: The results showed the apoptosis-inducing capacity of the C. kissi extract on K562 cells, and the impact was suggested to be through the induction of intracellular apoptosis and cell cycle arrest. Conclusion: The apoptosis induction on K562 caused by C. kissi was reported for the first time. Initial recognition of the signaling pathway of inhibition is through the BCR-ABL/PTEN.

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Cite This Article

Xuan, N. A., Quan, N. T., Ly, B. T. K., Chi, H. T. (2024). Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract. European Journal of Biology, Volume: 83 Issue: 1. https://doi.org/10.26650/EurJBiol.2024.1399845

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