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Dergiler / Journal of the Turkish Chemical Society Section A: Chemistry / 2019 / Cilt: 6 - Sayı: 3

ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES

Hülya ÇELİK ONAR
Fatma Ceren ANLAŞ
Hasniye YAŞA
Fulya ÜSTÜN ALKAN
Belma HASDEMİR
Tülay BAKIREL
Sayfa
429–432
Yayın Tarihi
2019-10-20
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effective cytotoxic potential against CMT-U27 and IC50 concentrations were recorded at 1.952 µM and 54.00 µM, respectively.

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Amaç & Hipotez:This study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin.
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Temel Bulgular & Veri:This study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin.
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Sonuç & Katkı:Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effective cytotoxic potential against CMT-U27 and IC50 concentrations were recorded at 1.952 µM and 54.00 µM, respectively.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Anilide · Semicarbazone · Fatty Acid

Abstract

This study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin. Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effective cytotoxic potential against CMT-U27 and IC50 concentrations were recorded at 1.952 µM and 54.00 µM, respectively.

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Bu Makaleye Atıf Yap

ONAR, H. Ç., ANLAŞ, F. C., YAŞA, H., ALKAN, F. Ü., HASDEMİR, B., BAKIREL, T. (2019). ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 6 - Sayı: 3, 429–432. https://ajindex.com/articles/781286

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