The main aim of the study is to determine the effects of substituents on antioxidant activity.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:In this study; Numerous coumarin compounds were synthesized by Pechmann and Knoevenagel methods, and the substitution of the formyl group was provided by the Duff reaction.
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Temel Bulgular & Veri:The IR spectras and melting points of the synthesized compounds were compared with the literature values.
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Sonuç & Katkı:The main aim of the study is to determine the effects of substituents on antioxidant activity.
In this study; Numerous coumarin compounds were synthesized by Pechmann and Knoevenagel methods, and the substitution of the formyl group was provided by the Duff reaction. The IR spectras and melting points of the synthesized compounds were compared with the literature values. Also confirmed by GC/MS analysis. And the synthesized coumarin derivatives were compared in terms of antioxidant activity according to DPPH and Cuprac methods. The main aim of the study is to determine the effects of substituents on antioxidant activity.
ONAR, H. Ç., YAŞA, H., SİN, O. (2020). Comparison of Antioxidant Activities of Mono-, Di- and Tri-substituted Coumarins. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 7 - Sayı: 1, 87–96. https://ajindex.com/articles/781241
Khan KM, Saıfy ZS, Hayat S, Khan MZ, Noor F, Makhmoor T, Choudhary MI, Zıa-ullah MI, Perveen S. Synthesis, Antioxidant and Insecticidal Activities of Some Coumarin Derivatives. J. Chem. Soc. Pac. 2002; 24 (3): 226-230
Yao C, Zeng H. Synthesis and Spectroscopic Study of Coumarin Derivatives,UV-Vis absorption spectroscopy and fluorescence spectroscopy, 2011; 27 (4): 599-603
O'Kennedy R, Thornes RD, Coumarins: Biology, Applications and Mode of Action, John Wiley and Sons, Chichester, ISBN: 978-0-471-96997-6, p. 348-360 (1997)
Bigi F, Chesini L, Maggi R, Sartori G, Montmorillonite KSF as an Inorganic Water Stable, and Reusable Catalyst for the Knoevenagel Synthesis of Coumarin-3-carboxylic Acids, J. Org. Chem. 1999; 64 (3): 1033-1035
Mausssaaoui Y, Ben Selam R, CR Chim. 2007; 10 (12): 1162-1169
Adreani LL, Lapi E. One some new esters of coumarin-3-carboxylic acid with balsamic and bronchodilator action. Boll. Chim. Farm. 1960; 99: 583-586
Polyansky DE, Necker DC. Photodecomposition of Organic Peroxides Containing Coumarin Chromophore: Spectroscopic Studies. J. Phys. Chem. 2005; 109/12: 2793-2800
Bolakatti GS, Maddi VS, Mamledesai SN, Ronad PM, Palkar MB, Swamy S. Synthesis and evaluation of antiinflammatory and analgesic activities of a novel series of coumarin Mannich bases. Arzneim. Forsch. 2008; 58 (10): 515-520
Tanaka T, Yamashita K, Hayashi M. Titanium Tetraisopropoxide Promoted Reactions for the Synthesis of Substituted Coumarins. Heterocycles. 2010; 80 (1): 631-636
Yuan HY, Wang M, Liu YJ, Liu Q. Copper(II)-Catalyzed C-C Bond-Forming Reactions of α-Electron–Withdrawing Group-Substituted Ketene S,S- Acetals with Carbonyl Compounds and a Facile Synthesis of Coumarins. Adv. Synth. Catal. 2009; 351 (1-2): 112-116
Kokare ND, Sangshetti JN, Shinde DB. Oxalic acid catalyzed solvent-free one pot synthesis of coumarins. Chinese Chem. Lett. 2007; 18 (11): 1309-1312
Montazeri N, Khaksar S, Nazari A, Alavi SS, Vahdat SM, Tajbakhsh M. Pentafluorophenylammonium triflate (PFPAT): An efficient, metal-free and Reusable catalyst for the von Pechmann reaction. J. Fluor. Chem. 2011; 132 (7): 450-452
Pozdnev VF. Improved method for synthesis of 7-amino-4-methylcoumarin, Chem. Heterocycl. Compd. 1990; 26 (3): 264-265
Murty KS, Rao PS, Seshadri TR. Geometrical Inversion in the Acids derived from The Coumarins Part 6 The Behaviour of the Acids derive from 4-Methyl- Coumarin, Proceedings–Indian Academy of Sciences. 19