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Dergiler / International Journal of Innovative Research and Reviews / 2019 / Cilt: 3 - Sayı: 2

Antibiotic resistance and efflux pumps

Eda ALTINÖZ
Ergin Murat ALTUNER
Sayfa
1–9
Yayın Tarihi
2019-12-15
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Understanding efflux pumps and discovering new inhibitors against these pumps could probably save the future of human beings.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The main purpose of this manuscript is to review the resistance against antibiotics and efflux pumps, one of the mechanisms important in resistance against antibiotics.
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Temel Bulgular & Veri:As a definition, the resistance against antibiotics is accepted as the capability of a microorganism to resist the activity of antimicrobials, which were successfully used to kill the microorganism once.
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Sonuç & Katkı:Understanding efflux pumps and discovering new inhibitors against these pumps could probably save the future of human beings.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antibiotic resistance · Efflux pumps · Inhibitors

Abstract

The main purpose of this manuscript is to review the resistance against antibiotics and efflux pumps, one of the mechanisms important in resistance against antibiotics. As a definition, the resistance against antibiotics is accepted as the capability of a microorganism to resist the activity of antimicrobials, which were successfully used to kill the microorganism once. Antibiotic resistance is characterized by several antibiotic susceptibility tests. The wide consumption of antibiotics; the over prescription of antimicrobial drugs by medical doctors; unnecessary, incorrect and inadequate self-medication by the patient and use of several antimicrobial agents either to support a healthy growth or therapeutic purposes in animals consumed as food triggered severe antibiotic resistance. Therefore, the resistance against antimicrobials became a considerable, wide-spread issue in all around the world and the studies have been initiated to overcome the resistance against antibiotics. There are several different mechanisms, which could lead bacteria to be resistant overtime. One of the mechanism of action, which leads to antibiotic resistance, is efflux pumps. Several efflux pump inhibitors were discovered until now, but since some of them are highly cytotoxic, they have very limited use. Understanding efflux pumps and discovering new inhibitors against these pumps could probably save the future of human beings.

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Bu Makaleye Atıf Yap

ALTINÖZ, E., ALTUNER, E. M. (2019). Antibiotic resistance and efflux pumps. International Journal of Innovative Research and Reviews, Cilt: 3 - Sayı: 2, 1–9. https://ajindex.com/articles/767574

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Kaynakça (8)

  1. Drexler M. What You Need to Know about Infectious Disease. Institute of Medicine (US): National Academies Press (US) (2010). Epstein PR. Commentary: Pestilence and Poverty—Historical Transitions and the Great Pandemics. American Journal of Preventive Medicine (1992) 8(4):263–265. Töreci K. Antibiyotik kullanimi ve direnç iliskisi [The relationship between antibiotic use and resistance]. Flora (2003) 8(2):89–110.
  2. Çiftçi A, Aksoy A. Acquired Resistance Mechanisms Against Antibiotics. Turkiye Klinikleri Journal of Veterinary Sciences- Pharmacology and Toxicology-Special Topics (2015) 1(2):1–10. Gökçe T. Birinci basamak saglik kurulusuna basvuran hastalarin antibiyotik kullanimi konusundaki davranis ve bilgi düzeylerinin arastirilmasi [Research on habits and awareness levels on the antibiotic use of the patients who consult primary care health services]. Pamukkale University. Infectious Diseases Society of America. Bad Drugs, No Drugs: Infectious Diseases Society of America (2010).
  3. Conly JM, Johnston BL. Where are all the new antibiotics? The new antibiotic paradox. Canadian Journal of Infectious Diseases and Medical Microbiology (2005) 16(3):159–160. Jacoby G. History of Drug-Resistant Microbes. In: Mayers D, Sobel J, Ouellette M, Marchaim D, editors. Antimicrobial Drug Resistance: Humana Press (2009).
  4. Knobler SL, Lemon SM, Najafi M, Burroughs T. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary: The National Academies Press (2003).
  5. Pankey G, Sabath L. Clinical Relevance of Bacteriostatic versus Bactericidal Activity in the Treatment of Gram-Positive Bacterial Infections. Clinical Infectious Diseases (2004) 38(6):864–870.
  6. Kohanski M, Dwyer D, Collins J. How antibiotics kill bacteria: from targets to networks. Nature Reviews Microbiology (2010) 8(6):423– Kapoor G, Saigal S, Elongavan A. Action and resistance mechanisms of antibiotics: A guide for clinicians. Journal of Anaesthesiology Clinical Pharmacology (2017) 33(3):300–305. Walsh C. Antibiotics: Actions, Origins, Resistance: ASM Press (2003).
  7. Silhavy T, Kahne D, Walker S. The Bacterial Cell Envelope. Cold Spring Harbor Perspectives in Biology (2010) 2(5):a000414- a000414. Vollmer W, Blanot D, Pedro M de. Peptidoglycan structure and architecture. FEMS Microbiology Reviews (2008) 32(2):149–167.
  8. Gan L, Chen S, Jensen G. Molecular organization of Gram-negative peptidoglycan. Proceedings of the National Academy of