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Dergiler / Hittite Journal of Science and Engineering / 2023 / Cilt: 10 Sayı: 2

Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations

Mahmut GÜR
Merve ZURNACI
Eda ALTINÖZ
Nesrin ŞENER
Çiğdem ŞAHİN
Merve ŞENTURAN
İzzet ŞENER
Muhammet ÇAVUŞ
Ergin Murat ALTUNER
Sayfa
99–116
Yayın Tarihi
2023-06-30
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Finally, the electrochemical stabilities of the synthesized molecules have been analyzed by using cyclic voltammetry in 0.1 M TBAPF6 in DMSO as a supporting electrolyte.

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Amaç & Hipotez:In this study, 1,3,4-thiadiazole derivatives were obtained from the reaction of benzophenone-4,4'-dicarboxylic acid and N-substitute-thiosemicarbazide compounds with each other.
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Temel Bulgular & Veri:According to the MBC/MFC test, all the activities were found to be bacteriostatic, also, especially the biofilm inhibition activity of C1 against K. pneumoniae is noteworthy.
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Sonuç & Katkı:Finally, the electrochemical stabilities of the synthesized molecules have been analyzed by using cyclic voltammetry in 0.1 M TBAPF6 in DMSO as a supporting electrolyte.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Efflux pump inhibition · antibiofilm · antibacterial

Abstract

In this study, 1,3,4-thiadiazole derivatives were obtained from the reaction of benzophenone-4,4'-dicarboxylic acid and N-substitute-thiosemicarbazide compounds with each other. After the synthesis of the final products, some biological properties of these compounds such as antibiofilm, antimicrobial and efflux pump inhibiting efficiencies were evaluated. According to the MBC/MFC test, all the activities were found to be bacteriostatic, also, especially the biofilm inhibition activity of C1 against K. pneumoniae is noteworthy. In addition, C4 was observed to exhibit efflux pump inhibition activity in E. coli, whereas C2 and C3 in K. pneumoniae. The absorption and emission values of the molecules were obtained and electrochemical studies were performed. In addition; absorption, metabolism, distribution, excretion and toxicity (ADMET) scores were predicted using the pharmacokinetic properties of all 1,3,4-thiadiazole compounds. Finally, the electrochemical stabilities of the synthesized molecules have been analyzed by using cyclic voltammetry in 0.1 M TBAPF6 in DMSO as a supporting electrolyte.

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Bu Makaleye Atıf Yap

GÜR, M., ZURNACI, M., ALTINÖZ, E., ŞENER, N., ŞAHİN, Ç., ŞENTURAN, M., ŞENER, İ., ÇAVUŞ, M., ALTUNER, E. M. (2023). Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. Hittite Journal of Science and Engineering, Cilt: 10 Sayı: 2, 99–116. https://ajindex.com/articles/949692

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