Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightIf tumor regression is predicted during radiotherapy topossibly change doses of organs at risk, volumetric image guidance should be encouraged once per week,at least, to consider adaptive treatment when required to ensure the critical organ doses within safe limits.
📌 3 Maddede Bu Makale
Abstract
We present the case of a patient with esophageal cancer whose tumor size regression prompted re-planning to decrease the cardiac dose. A 68-year-old male presented at our outpatient clinic with dysphagia.He was diagnosed with clinical T3N1M0 adenocarcinoma located at the distal esophagus–esophagogastric junction. He was decided to have surgery after receiving neoadjuvant chemoradiotherapy. Following4-D CT simulation, IG-IMRT with SIB technique was planned as 50 Gy in 25 fractions to iGTV and as45 Gy to the area identified as the CTV. Daily kV and weekly CBCT were planned at the beginning ofthe treatment. Concurrent CT with weekly paclitaxel–carboplatin was administered. At the simulationand start of the treatment, the heart was pushed anteriorly due to the mass effect and dilatation in themid-lower esophagus. The mass and dilatation regressed at the weekly CBCT of the patient. The thirdweek CBCT evaluation revealed the movement of the heart posteriorly into the PTV. Re-simulation wasperformed to continue with the adaptive planning for the last 10 treatment fractions. The cumulative dosereceived by the heart was reduced from 96% to 93% for V5Gy, from 79% to 60.8% for V10Gy, from 60%to 43.2% for V15Gy, from 35% to 21% for V20Gy, and from 29.6 to 28 Gy for the mean cardiac dose withthe volumetric image-guided adaptive planning. If tumor regression is predicted during radiotherapy topossibly change doses of organs at risk, volumetric image guidance should be encouraged once per week,at least, to consider adaptive treatment when required to ensure the critical organ doses within safe limits.