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Dergiler / Türk Onkoloji Dergisi / 2017 / Cilt: 32 - Sayı: 2

Volumetric Arc Therapy Seems More Promising for Sparing Organs at Risk in Adjuvant Postoperative Radiotherapy for Pancreatic Adenocarcinoma than Step-and-Shoot Intensity-Modulated Radiotherapy

Uğur SELEK
Duygu SEZEN
Yasemin BÖLÜKBAŞI
Yücel SAĞLAM
Z. Vildan ALPAN
Steve KIRSNER
Sayfa
63–69
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This could be investigated as more tolerable concurrent radiochemotherapy treatment with better OAR preservation.

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Amaç & Hipotez:The aim of the present study was to determine if volumetric modulated arc therapy (VMAT) provided superior dose distribution than intensity-modulated radiotherapy (step-and-shoot; ssIMRT) based on target volume coverage and organs at risk (OARs) doses in postoperative radiotherapy for pancreatic cancer patients.METHODSNew 4-dimensional computed tomography plans for 10 pancreatic cancer patients were created.
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Temel Bulgular & Veri:The ssIMRT plans had 6 coplanar fields (330-0-30-60-90°) and VMAT plans were generated with 2 268-92° arcs.RESULTSVMAT plans revealed better overall sparing of right kidney (volume receiving 15% of prescribed dose [V15]: 28.3% vs 46.9%, p=0.012; V20: 16.1% vs 27.6%, p=0.007; V25: 8.6% vs 15.2%, p=0.005; mean dose 1549 centigray [cGy] vs 1987 cGy, p=0.005).
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Sonuç & Katkı:This could be investigated as more tolerable concurrent radiochemotherapy treatment with better OAR preservation.
🔬Tür:Araştırma Makalesi
📍Kapsam:2032 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

The aim of the present study was to determine if volumetric modulated arc therapy (VMAT) provided superior dose distribution than intensity-modulated radiotherapy (step-and-shoot; ssIMRT) based on target volume coverage and organs at risk (OARs) doses in postoperative radiotherapy for pancreatic cancer patients.METHODSNew 4-dimensional computed tomography plans for 10 pancreatic cancer patients were created. The ssIMRT plans had 6 coplanar fields (330-0-30-60-90°) and VMAT plans were generated with 2 268-92° arcs.RESULTSVMAT plans revealed better overall sparing of right kidney (volume receiving 15% of prescribed dose [V15]: 28.3% vs 46.9%, p=0.012; V20: 16.1% vs 27.6%, p=0.007; V25: 8.6% vs 15.2%, p=0.005; mean dose 1549 centigray [cGy] vs 1987 cGy, p=0.005). VMAT delivered similar isodose distribution (planning target volume [PTV] mean dose: 5164 vs 5183 cGy, PTV max: 5526 cGy vs 5505 cGy; p=0.541) with significantly fewer monitor units (MU) (MU: 468 vs 527; p=0.032) in comparison with ssIMRT. VMAT was also found to be superior for V30 intestinal dose, but mean dose was similar (1963 cGy vs 2032 cGy; p=0.05).CONCLUSIONVMAT provided more effective protection for bilateral kidneys and small intestine with better OAR doses, as well as for liver, with reduced high-dose volumes in this cohort. This could be investigated as more tolerable concurrent radiochemotherapy treatment with better OAR preservation.

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Bu Makaleye Atıf Yap

SELEK, U., SEZEN, D., BÖLÜKBAŞI, Y., SAĞLAM, Y., ALPAN, Z. V., KIRSNER, S. (2022). Volumetric Arc Therapy Seems More Promising for Sparing Organs at Risk in Adjuvant Postoperative Radiotherapy for Pancreatic Adenocarcinoma than Step-and-Shoot Intensity-Modulated Radiotherapy. Türk Onkoloji Dergisi, Cilt: 32 - Sayı: 2, 63–69. https://ajindex.com/articles/639284

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Kaynakça (8)

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